Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors

Caffeine Consumption Prevents Memory Impairment, Neuronal Damage, and Adenosine A2A Receptors Upregulation in the Hippocampus of a Rat Model of Sporadic Dementia

(2018) Janaína Espinosa et al.   JOURNAL OF ALZHEIMERS DISEASE

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

(2017) Diana G Ferreira et al.   NATURE NEUROSCIENCE

Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease

(2017) Emrin Horgusluoglu-Moloch et al.   NEUROBIOLOGY OF AGING

Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study

(2017) Marjo H. Eskelinen et al.   JOURNAL OF ALZHEIMERS DISEASE

Progressive Age-Related Impairment of the Late Long-Term Potentiation in Alzheimer's Disease Presenilin-1 Mutant Knock-in Mice

(2017) Alexandra Auffret et al.   JOURNAL OF ALZHEIMERS DISEASE

Caffeine and Coffee as Therapeutics Against Alzheimer's Disease

(2017) Gary W. Arendash et al.   JOURNAL OF ALZHEIMERS DISEASE

Age-Related Changes in the Synaptic Density of Amyloid-β Protein Precursor and Secretases in the Human Cerebral Cortex

(2016) Anna Pliássova et al.   JOURNAL OF ALZHEIMERS DISEASE

How does adenosine control neuronal dysfunction and neurodegeneration?

(2016) Rodrigo A. Cunha   JOURNAL OF NEUROCHEMISTRY

Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

(2016) Wenzhong Yang et al.   NEUROBIOLOGY OF AGING

Major dorsoventral differences in the modulation of the local CA1 hippocampal network by NMDA, mGlu5, adenosine A2A and cannabinoid CB1 receptors

(2016) S. Kouvaros et al.   NEUROSCIENCE

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

(2016) Silvia Viana da Silva et al.   Nature Communications

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

(2016) Vânia L. Batalha et al.   Scientific Reports

Deletion of Adenosine A2A Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

(2015) Marco Matos et al.   BIOLOGICAL PSYCHIATRY

Adenosine A2Areceptors are necessary and sufficient to trigger memory impairment in adult mice

(2015) N Pagnussat et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adenosine A2Areceptors permit mGluR5-evoked tyrosine phosphorylation of NR2B (Tyr1472) in rat hippocampus: a possible key mechanism in NMDA receptor modulation

(2015) Konstantinos Sarantis et al.   JOURNAL OF NEUROCHEMISTRY

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

(2015) P Li et al.   MOLECULAR PSYCHIATRY

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

Rescue of impaired late–phase long-term depression in a tau transgenic mouse model

(2015) Tariq Ahmed et al.   NEUROBIOLOGY OF AGING

Inactivation of adenosine A 2A receptors reverses working memory deficits at early stages of Huntington's disease models

(2015) Wei Li et al.   NEUROBIOLOGY OF DISEASE

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease

(2015) Shiraz Tyebji et al.   NEUROBIOLOGY OF DISEASE

Subchronic Glucocorticoid Receptor Inhibition Rescues Early Episodic Memory and Synaptic Plasticity Deficits in a Mouse Model of Alzheimer’s Disease

(2015) Fabien Lanté et al.   NEUROPSYCHOPHARMACOLOGY

Caffeine acts through neuronal adenosine A2Areceptors to prevent mood and memory dysfunction triggered by chronic stress

(2015) Manuella P. Kaster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP as a multi-target danger signal in the brain

(2015) Ricardo J. Rodrigues et al.   Frontiers in Neuroscience

Synaptic mechanisms of adenosine A2Areceptor-mediated hyperexcitability in the hippocampus

(2014) Diogo M. Rombo et al.   HIPPOCAMPUS

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

(2014) C Laurent et al.   MOLECULAR PSYCHIATRY

Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology

(2014) Cyril Laurent et al.   NEUROBIOLOGY OF AGING

Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety

(2014) Joana E. Coelho et al.   Frontiers in Psychiatry

Altered Calcium Metabolism in Aging CA1 Hippocampal Pyramidal Neurons

(2013) M. M. Oh et al.   JOURNAL OF NEUROSCIENCE

Ecto-5'-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions

(2013) E. Augusto et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Firing properties of entorhinal cortex neurons and early alterations in an Alzheimer's disease transgenic model

(2013) Andrea Marcantoni et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression

(2013) S. Nabavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model

(2012) Sylvie Burnouf et al.   AGING CELL

Neuroprotection afforded by adenosine A2Areceptor blockade is modulated by corticotrophin-releasing factor (CRF) in glutamate injured cortical neurons

(2012) Jorge S. Valadas et al.   JOURNAL OF NEUROCHEMISTRY

Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation

(2012) V L Batalha et al.   MOLECULAR PSYCHIATRY

Hippocampal long-term depression mediates spatial reversal learning in the Morris water maze

(2012) Zhifang Dong et al.   NEUROPHARMACOLOGY

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Adenosine and Related Drugs in Brain Diseases: Present and Future in Clinical Trials

(2011) Luisa V. Lopes et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hippocampus upon ageing

(2011) Ana R. Costenla et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Quantification of nanoparticle uptake by cells using an unbiased sampling method and electron microscopy

(2011) Andreas Elsaesser et al.   Nanomedicine

Enhancement of LTP in Aged Rats is Dependent on Endogenous BDNF

(2011) Maria J Diógenes et al.   NEUROPSYCHOPHARMACOLOGY

Age-Related Progressive Synaptic Dysfunction: The Critical Role of Presenilin 1

(2011) Alexandra Auffret et al.   REVIEWS IN THE NEUROSCIENCES

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

(2011) Cristina Marchetti et al.   REVIEWS IN THE NEUROSCIENCES

Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region after transient global ischemia in rats

(2010) Norio Takagi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Long-term depression in the CNS

(2010) Graham L. Collingridge et al.   NATURE REVIEWS NEUROSCIENCE

Hippocampal long-term depression is required for the consolidation of spatial memory

(2010) Y. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histology of the Central Nervous System

(2010) Robert H. Garman   TOXICOLOGIC PATHOLOGY

Synaptic Adaptations of CA1 Pyramidal Neurons Induced by a Highly Effective Combinational Antidepressant Therapy

(2009) Cristina Marchetti et al.   BIOLOGICAL PSYCHIATRY

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

Image analysis of Ca2+ signals as a basis for neurotoxicity assays: Promises and challenges

(2009) Rola Barhoumi et al.   NEUROTOXICOLOGY AND TERATOLOGY

RESEARCH ARTICLE: Up-regulation of Adenosine Receptors in the Frontal Cortex in Alzheimer's Disease

(2008) José L. Albasanz et al.   BRAIN PATHOLOGY

Increased intraneuronal resting [Ca2+] in adult Alzheimer’s disease mice

(2008) José R. Lopez et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Modification upon aging of the density of presynaptic modulation systems in the hippocampus

(2008) Paula M. Canas et al.   NEUROBIOLOGY OF AGING

Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses

(2008) Nelson Rebola et al.   NEURON

Caffeine prevents age-associated recognition memory decline and changes brain-derived neurotrophic factor and tirosine kinase receptor (TrkB) content in mice

(2008) M.S. Costa et al.   NEUROSCIENCE

Impaired calcium homeostasis in aged hippocampal neurons

(2008) Parvana Hajieva et al.   NEUROSCIENCE LETTERS

Adenosine A2A receptor blockade prevents memory dysfunction caused by β-amyloid peptides but not by scopolamine or MK-801

(2007) Geanne M.A. Cunha et al.   EXPERIMENTAL NEUROLOGY