Article
Hematology
Michael H. Kramer, Qiang Zhang, Robert Sprung, Ryan B. Day, Petra Erdmann-Gilmore, Yang Li, Ziheng Xu, Nichole M. Helton, Daniel R. George, Yiling Mi, Peter Westervelt, Jacqueline E. Payton, Sai M. Ramakrishnan, Christopher A. Miller, Daniel C. Link, John F. DiPersio, Matthew J. Walter, R. Reid Townsend, Timothy J. Ley
Summary: This study revealed previously undescribed features of AML patients through proteomic and phosphoproteomic data, such as posttranscriptionally regulated proteins and abnormal phosphorylation sites. These findings provide insights into protein dysregulation in AML pathogenesis.
Editorial Material
Biochemistry & Molecular Biology
Magalie Dosset, Maurizio Zanetti
Summary: Disulfiram, a drug commonly used for alcohol use disorders, has been repurposed for cancer treatment and plays a role in cancer immunotherapy by directly binding to Lck to activate tumor-infiltrating T cells.
Article
Cell Biology
Yan Ding, Guiping Wang, Meixiao Zhan, Xiaohan Sun, Yanran Deng, Yunhe Zhao, Bin Liu, Qingxin Liu, Shian Wu, Zizhang Zhou
Summary: Metastasis is a significant cause of mortality in malignant tumors, and understanding the molecular mechanisms involved can aid in the development of anti-cancer drugs. The Hippo pathway has been found to inhibit tumor cell metastasis, while inhibition of this pathway promotes tumor cell migration through activating SRC. Furthermore, the positive feedback loop between YAP and SRC also plays a crucial role in promoting hepatocellular carcinoma cell migration.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jean-Marie Sontag, Diana Schuhmacher, Goce Taleski, Anthony Jordan, Sarah Khan, Alexander Hoffman, Rey J. Gomez, Matthew D. Mazalouskas, Steven K. Hanks, Benjamin W. Spiller, Estelle Sontag, Brian E. Wadzinski
Summary: This study reveals that PP2A can be phosphorylated at both Tyr127 and Tyr284 upon Src activation, and at Tyr284 following Fyn activation. These phosphorylation events enhance the interaction of PP2Ac with SFKs.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Editorial Material
Hematology
Monika Haemmerle
Summary: This study explores the role of Mnk1 in megakaryocytes and platelets, showing that it regulates protein synthesis and affects megakaryocyte ploidy and platelet production. These findings have clinical implications and contribute to our understanding of platelet function and thrombosis.
Article
Biochemistry & Molecular Biology
Kyunghee Noh, Duc-Hiep Bach, Hyun-Jin Choi, Mark S. Kim, Sherry Y. Wu, Sunila Pradeep, Cristina Ivan, Min-Soon Cho, Emine Bayraktar, Cristian Rodriguez-Aguayo, Santosh K. Dasari, Elaine Stur, Lingegowda S. Mangala, Gabriel Lopez-Berestein, Anil K. Sood
Summary: This study revealed a previously unrecognized mechanism whereby PXN enhances angiogenesis by transcriptionally regulating SRC expression, leading to increased PLAT expression and ultimately promoting angiogenesis in endothelial cells through LRP1. Silencing PXN in ovarian cancer mouse models reduced angiogenesis, tumor growth, and metastasis.
Article
Pharmacology & Pharmacy
Ting Zheng, Han-yu Wang, Yang Chen, Xiao Chen, Zi-ling Wu, Qin-yu Hu, Hui Sun
Summary: This study found that Src plays a key role in the development of diabetic nephropathy through the inhibition of FUNDC1-mediated mitophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Fang Du, Tao Tang, Qingzhu Li, Jiaxin Liu
Summary: Ischemic stroke is a common type of stroke that causes disability and death. Fyn, a nonreceptor tyrosine kinase, plays a crucial role in the pathological processes of cerebral ischemia-reperfusion, including energy metabolism disorders, neurotoxicity, and apoptotic gene activation. Fyn also promotes the production of superoxide, contributing to cerebral ischemia-reperfusion injury. Exploring the role of Fyn is important for understanding the mechanisms of cerebral ischemia-reperfusion injury and developing treatment strategies.
MEDIATORS OF INFLAMMATION
(2022)
Article
Neurosciences
Vishaal Rajani, Ameet S. Sengar, Michael W. Salter
Summary: SFKs are crucial non-receptor tyrosine kinases in multiple signalling pathways, playing a key role in regulating NMDAR function and neuronal transduction pathways. Src and Fyn members of SFKs are essential for inducing plasticity at hippocampal synapses, while aberrant regulation of NMDARs by SFKs is implicated in diseases like schizophrenia and pain hypersensitivity. The targeting of SFK protein-protein interactions could be a potential therapeutic strategy for restoring glutamatergic dysregulation in CNS disease pathophysiology.
Article
Pharmacology & Pharmacy
Yawei Xu, Yalei Ning, Yan Zhao, Yan Peng, Fen Luo, Yuanguo Zhou, Ping Li
Summary: Caffeine as a nonspecific antagonist of the adenosine A(2A) receptor enhances learning and memory function while also correlating with feelings of anxiety. The differential effects of inhibiting A(2A)Rs in the dorsal and ventral hippocampus lead to enhanced memory and increased anxiety, respectively. Optogenetic activation of dorsal or ventral hippocampal A(2A)Rs can reverse these behavioral alterations caused by caffeine intake.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sara G. Pelaz, Arantxa Tabernero
Summary: This review summarizes recent progress in understanding the role of Src in glucose metabolism in cancer cells and discusses its link with metabolic plasticity and tumor progression. The opportunities and challenges in this field are also discussed.
Article
Cell Biology
Zehan Hu, Devanarayanan Siva Sankar, Bich Vu, Alexandre Leytens, Christine Vionnet, Wenxian Wu, Michael Stumpe, Esther Martinez-Martinez, Bjoern Stork, Joern Dengjel
Summary: ULK1 kinase complex is a key regulator of autophagy, phosphorylating autophagy-relevant proteins for autophagosome maturation and turnover. It also interacts closely with various phosphatase complexes, such as PP2A, to coordinate protein degradation through autophagy.
Article
Cell Biology
Chen Wang, Jie Zeng, Li-Jie Li, Min Xue, Si-Li He
Summary: The study showed that Cdc25A regulates ferroptosis in cervical cancer cells by modulating the levels of PKM2 and ErbB2, affecting the response of cervical cancer cells to sorafenib treatment.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Yuran Qiu, Yuanhao Wang, Zongtao Chai, Duan Ni, Xinyi Li, Jun Pu, Jie Chen, Jian Zhang, Shaoyong Lu, Chuan Lv, Mingfei Ji
Summary: RAS is a key oncogenic protein, and mutations in it can lead to human cancer. Recent studies have identified several phosphorylation residues in RAS protein that can regulate its activity, providing a new direction for developing anti-RAS drugs. This review summarizes the research advances in RAS phosphorylation and provides insights into therapeutic strategies.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Biochemistry & Molecular Biology
Jiutao Wang, Ning Yao, Yamei Hu, Mingjuan Lei, Meixian Wang, Lu Yang, Satyananda Patel, Xiang Li, Kangdong Liu, Zigang Dong
Summary: This study identified the potential mechanism of how Ras is activated in glioblastoma multiforme (GBM) through the interaction between Ras and PHLDA1. The overexpression of PHLDA1 promoted cell proliferation and tumor growth by regulating the Ras/Raf/Mek/Erk signaling pathway. In addition, Src phosphorylated Ras at tyrosine 32 to enhance its GTPase activity. PHLDA1 competed with Src for binding to Ras, inhibiting Ras phosphorylation by Src and rescuing Ras activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Stylianos Kouvaros, Costas Papatheodoropoulos
Article
Biochemistry & Molecular Biology
Costas Papatheodoropoulos
FRONTIERS IN BIOSCIENCE-LANDMARK
(2018)
Article
Biochemistry & Molecular Biology
Paraskevi Krania, Eleni Dimou, Maria Bantouna, Stylianos Kouvaros, Eirini Tsiamaki, Costas Papatheodoropoulos, Konstantinos Sarantis, Fevronia Angelatou
JOURNAL OF NEUROCHEMISTRY
(2018)
Article
Behavioral Sciences
Vassilios Papaleonidopoulos, Costas Papatheodoropoulos
NEUROBIOLOGY OF LEARNING AND MEMORY
(2018)
Article
Neurosciences
Vassilios Papaleonidopoulos, Stylianos Kouvaros, Costas Papatheodoropoulos
Article
Neurosciences
Efstratios K. Kosmidis, Yiannis F. Contoyiannis, Costas Papatheodoropoulos, Fotios K. Diakonos
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Andriana Koutsoumpa, Costas Papatheodoropoulos
Article
Neurosciences
George Trompoukis, Pavlos Rigas, Leonidas J. Leontiadis, Costas Papatheodoropoulos
MOLECULAR AND CELLULAR NEUROSCIENCE
(2020)
Article
Neurosciences
George Trompoukis, Leonidas J. Leontiadis, Pavlos Rigas, Costas Papatheodoropoulos
Summary: The functional organization of the hippocampus along its longitudinal axis shows significant heterogeneity. Development of sharp wave and ripples (SPW-Rs) varies between the ventral and dorsal hippocampus, with the ventral hippocampus showing more gradual development. Changes in local network excitability and inhibition play a significant role in the generation of SPW-Rs, particularly in the ventral hippocampus.
Article
Neurosciences
Andriana Koutsoumpa, Costas Papatheodoropoulos
Summary: The study found that the dorsal and ventral hippocampal CA1 regions exhibit different response patterns to frequencies of input from the entorhinal cortex, showing facilitation or inhibition at different locations for high and low frequency inputs. This suggests that there is frequency selectivity in the direct and indirect inputs from the entorhinal cortex across the hippocampal CA1 region, and rapid information processing may occur independently through different circuits.
Article
Developmental Biology
George Trompoukis, Giota Tsotsokou, Andriana Koutsoumpa, Maria Tsolaki, Georgia Vryoni, Costas Papatheodoropoulos
Summary: The study found that there are significant changes in short-term neural information processing in the dorsal hippocampus of old rats, while the ventral hippocampus generally remains unchanged. The neural information processing capacity in old rats is reduced in frequency-dependent transient changes compared to young rats.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Athina Miliou, Vassilis Papaleonidopoulos, George Trompoukis, Costas Papatheodoropoulos
Summary: Recent evidence suggests that beta-adrenergic receptors have a greater facilitating effect on long-term synaptic plasticity in the ventral hippocampus compared to the dorsal hippocampus. Activation of beta-ARs by isoproterenol specifically enhances synaptic output from the dorsal hippocampus at certain frequencies without affecting short-term synaptic plasticity. Additionally, isoproterenol increases basal synaptic transmission and neuronal excitation more in the dorsal hippocampus than the ventral hippocampus, indicating functional specialization along the longitudinal axis of the hippocampus.
IBRO NEUROSCIENCE REPORTS
(2021)
Article
Neurosciences
Leonidas J. Leontiadis, George Trompoukis, Panagiotis Felemegkas, Giota Tsotsokou, Athina Miliou, Costas Papatheodoropoulos
Summary: An imbalance between excitation and inhibition in the brain is a common neurobiological mechanism in neurodevelopmental disorders. This study found increased neuronal excitability and synaptic transmission in both the dorsal and ventral hippocampus of a rat model of fragile X syndrome (FXS). Interestingly, the ventral hippocampus showed increased synaptic inhibition and a reduced rate of epileptiform discharges, while the dorsal hippocampus displayed an increased rate of epileptiform discharges. These findings suggest that the increased excitability in the dorsal hippocampus contributes to epileptic activity, while the increased inhibition in the ventral hippocampus may play a compensatory role in reducing vulnerability to seizures.
Article
Neurosciences
George Trompoukis, Costas Papatheodoropoulos
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2020)
Article
Neurosciences
Vassilios Papaleonidopoulos, George Trompoukis, Andriana Koutsoumpa, Costas Papatheodoropoulos
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)