Review
Chemistry, Multidisciplinary
Patrycja Talarska, Maciej Boruczkowski, Jakub Zurawski
Summary: Silver and gold nanoparticles are widely used in various household products, raising concerns about their potential impact. Research is focusing on the effects of nanoparticles on cell function and environmentally friendly alternatives to chemically synthesized nanoparticles.
Review
Biochemistry & Molecular Biology
Ahmad Sohrabi Kashani, Muthukumaran Packirisamy
Summary: Understanding the unknown mechanobiological responses to nano-bio-interaction is crucial in designing safe and effective nanomedicines. Studies have shown that the mechanobiological properties of cells, such as elasticity and adhesion, play key roles in cellular functions and cancer progression. Monitoring the mechanobiological responses of treated cells can help evaluate the efficiency of nanomedicines and develop applications to modulate cell mechanics for controlling cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Ankan Kumar Sarkar, Santanu Shaw, Himali Arora, Pankaj Seth, Nikhil R. R. Jana
Summary: Subcellular targeting of drugs can be enhanced by designing nanocarriers for direct cell membrane translocation, bypassing endosomal/lysosomal trafficking. This approach allows rapid and extensive delivery of drugs to the cell nucleus within a few minutes, without undergoing vesicular coating and lysosomal trafficking. This nonendocytic uptake method provides a potential strategy for nanocarrier-based subcellular targeting of drugs for more effective therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Haibo Chen, Xuewei Dong, Luping Ou, Chiyun Ma, Bing Yuan, Kai Yang
Summary: In this study, the interaction between irradiated nanoparticles (NPs) and lipid bilayer membranes was investigated using molecular dynamics simulations. The results showed that the wrapping of membranes around NPs is thermally regulated and dependent on NP properties and lipid species. These findings offer valuable insights for understanding cellular internalization of NPs and developing strategies to modulate NP endocytosis.
Article
Multidisciplinary Sciences
Xiao-Dong Sun, Jing-Ya Ma, Li-Juan Feng, Jian-Lu Duan, Xiao-Min Xie, Xiao-Han Zhang, Xiangpei Kong, Zhaojun Ding, Xian-Zheng Yuan
Summary: Understanding the interaction between nanoparticles and plant interfaces is crucial for the application of nanotechnology in plant agriculture. This study examined the iron transport capacity of Fe3O4 nanoparticles coated with citrate or polyacrylic acid in the plant rhizosphere. The results showed that citrate-coated particles had a stronger effect in preventing iron chlorosis compared to PAA-coated particles, by releasing more soluble iron through binding to acidic root exudates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Nanoscience & Nanotechnology
Haixiao Wan, Duo Xu, Lijuan Gao, Li-Tang Yan
Summary: This article provides a comprehensive review on the major types of entropy in biological systems and their underlying physical principles. It focuses on the physical mechanisms arising from entropy in the cellular uptake process and discusses the remaining challenges and future directions for manipulating entropy-mediated nanoparticle cellular uptake.
Article
Crystallography
Abdul Ghaffar Memon, Iftikhar Ahmed Channa, Asif Ahmed Shaikh, Jabran Ahmad, Abdul Fatah Soomro, Abdulmoseen Segun Giwa, Zenab Tariq Baig, Wael A. A. Mahdi, Sultan Alshehri
Summary: This study successfully synthesized gold nanoparticles using citrate reduction method and characterized their properties and morphology through various techniques. The gold nanoparticles exhibited superior UV-absorbance and crystalline structure, indicating potential applications in various fields.
Article
Biology
Alla P. Toropova, Andrey A. Toropov, Danuta Leszczynska, Jerzy Leszczynski
Summary: This study focuses on developing computational models to investigate the cellular uptake potential of gold nanoparticles (GNPs) by A549 cells under various conditions using quasi-SMILES. The models exhibit good statistical quality.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yue Hao, Shu Bai, Linling Yu, Yan Sun
Summary: In this study, a magnetically driven, mucus-inert Janus-type nanovehicle was fabricated, which effectively improved the diffusion and endocytosis of the nanovehicles in mucus.
Article
Agriculture, Multidisciplinary
Takashi Ito, Mao Odama, Eiji Maegawa, Kohsuke Suzuki, Yujiro Fujii, Reika Maeda, Shigeru Murakami
Summary: This study investigated the effects of pentacyclic triterpenoids, including betulinic acid (BA), on the cellular proliferation and senescence of normal human dermal fibroblasts (NHDFs). BA treatment increased the proliferation of young fibroblasts and reduced the proportion of senescent cells in high-passage NHDFs. The downregulation of interferon (IFN)-inducible genes, including IFIT1, IFITM1, IFI6, MX1, and OAS2, by BA suggested the suppression of the type I IFN signaling pathway. BA also downregulated the expression of the IRF9 transcriptional factor downstream of the type 1 IFN signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Magda F. Serra, Amanda C. Cotias, Andreza S. Pimentel, Ana Carolina S. de Arantes, Ana Lucia A. Pires, Manuella Lanzetti, Jandir M. Hickmann, Emiliano Barreto, Vinicius F. Carvalho, Patricia M. R. E. Silva, Renato S. B. Cordeiro, Marco Aurelio Martins
Summary: This study found that nebulized gold nanoparticles (AuNPs) can improve steroid-insensitive asthma by preserving HDAC2 and NRF2 levels, reducing oxidative stress and inflammation.
Review
Nanoscience & Nanotechnology
Yajuan Liu, Mei Li, Haisha Liu, Chao Kang, Xiyong Yu
Summary: Nanoparticle-based drug delivery systems have the potential to enhance the properties of drugs by enabling targeted delivery. Monitoring the intracellular behavior of nanoparticles is crucial but challenging. The recent advancements in Raman techniques provide a versatile tool for noninvasive cellular measurements.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
A. Jakhmola, S. Krishnan, V. Onesto, F. Gentile, M. Profeta, A. Manikas, E. Battista, R. Vecchione, P. A. Netti
Summary: This study developed a simple method for preparing gold nanoparticles with multimodal properties. The nanoparticles were synthesized using trisodium citrate as a reducing, stabilizing, and shape-modulating agent at room temperature. The resulting gold nanoparticles had diverse shapes, good monodispersity, high surface-enhanced Raman scattering activity, and a wide absorption range. The optical properties and growth characteristics of the nanoparticles were investigated experimentally and numerically. In vitro studies demonstrated the biocompatibility of the nanoparticles with cells.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Analytical
Abbas Karami, Masoumeh Hasani
Summary: This study presents a new biosensing platform called nano-sweeping for quantitative detection of miRNA-30a. The method utilizes gold nanoparticle-core spherical nucleic acid hybridization and gravitational separation to achieve rapid and accurate quantification of miRNA-30a. The approach is fluorophore independent, allowing for attachment of any fluorescent dye, and has a linear response within a concentration range of 0-3.55 ng/μL.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Yasmin Arezki, Francois Delalande, Christine Schaeffer-Reiss, Sarah Cianferani, Mickael Rapp, Luc Lebeau, Francoise Pons, Carole Ronzani
Summary: This study reported the first quantitative proteomic analysis of the protein corona formed on carbon dots (CDs) with different surface charge properties, showing that the surface charge properties of CDs influence protein corona composition, which in turn affects CD uptake and viability in macrophages.
Article
Engineering, Biomedical
Aldy Aliyandi, Catharina Reker-Smit, Inge S. Zuhorn, Anna Salvati
Summary: Targeted drug delivery relies on the specific interaction between nanocarriers and cell surface receptors for efficient internalization. By using cell surface biotinylation, we identified the receptors mediating nanoparticle uptake. Vitronectin corona was found to enhance the uptake of nanoparticles in brain and liver endothelial cells by targeting integrin receptors.
ACTA BIOMATERIALIA
(2023)
Letter
Toxicology
P. Marx-Stoelting, G. Riviere, M. Luijten, K. Aiello-Holden, N. Bandow, K. Baken, A. Canas, A. Castano, S. Denys, C. Fillol, M. Herzler, I. Iavicoli, S. Karakitsios, J. Klanova, M. Kolossa-Gehring, A. Koutsodimou, J. Lobo Vicente, I. Lynch, S. Namorado, S. Norager, A. Pittman, S. Rotter, D. Sarigiannis, M. J. Silva, J. Theunis, T. Tralau, M. Uhl, J. van Klaveren, L. Wendt-Rasch, E. Westerholm, C. Rousselle, P. Sanders
Summary: Current approaches for chemical risk assessment are facing challenges due to the increasing number and changing types of chemicals. Next-generation risk assessment is seen as the way forward, but incorporating new scientific insights and innovative approaches is challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) aims to address these challenges and consolidate Europe's research and innovation capacity in chemical risk assessment.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Chemistry, Analytical
Hicham Meskher, Teqwa Ragdi, AmritKumar Thakur, Sohmyung Ha, Issam Khelfaoui, Ravishankar Sathyamurthy, SwellamW. Sharshir, A. K. Pandey, Rahman Saidur, Punit Singh, Fariborz Sharifianjazi, Iseult Lynch
Summary: Carbon nanotubes (CNTs) are safe, biocompatible, bioactive, and biodegradable materials that have attracted significant attention due to their unique characteristics in various applications. This review focuses on the use of CNT-based nanocomposites in the production of electrochemical sensors and biosensors. It highlights the synthesis and optimization of CNT-based sensors for different applications and discusses the advantages of using CNTs for biomolecule immobilization. The use of molecularly imprinted polymer (MIP)-CNTs in electrochemical sensor production is also addressed, along with the challenges and future perspectives in this field.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Review
Environmental Sciences
Xiaowei Li, Yiqing Chen, Shujing Zhang, Yuling Dong, Qiuxiang Pang, Iseult Lynch, Changjian Xie, Zhiling Guo, Peng Zhang
Summary: This review article examines the fate and impact of microplastics on marine and freshwater organisms, exploring their toxic mechanisms and ecological consequences. It also discusses the factors affecting their toxicity and future research trends in microplastics ecotoxicology.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Changjian Xie, Xiaowei Li, Zhiling Guo, Yuling Dong, Shujing Zhang, Ao Li, Shan Ma, Jianing Xu, Qiuxiang Pang, Willie J. G. M. Peijnenburg, Iseult Lynch, Peng Zhang
Summary: The toxicity of graphene oxide (GO) in aquatic systems was evaluated using the freshwater planarian Dugesia japonica. GO not only impaired the growth of normal worms, but also inhibited the regeneration processes of regenerating worms. High concentration of GO killed all the worms. Mechanistic analysis suggests that GO disturbed the antioxidative system and energy metabolism, causing oxidative damage and retardance of neuron regeneration.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Sarah Deville, Hector Garcia Romeu, Eline Oeyen, Inge Mertens, Inge Nelissen, Anna Salvati
Summary: Extracellular vesicles play a critical role in intercellular communication, particularly in the immune response. Macrophages release these vesicles in response to various stimuli, but little is known about how their composition changes when exposed to nanoparticles. In this study, alveolar-like macrophages were exposed to different nanoparticles, and the released extracellular vesicles were characterized using various techniques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Anna Kukkola, Stefan Krause, Yasmin Yonan, Liam Kelleher, Uwe Schneidewind, Gregory H. Sambrook Smith, Holly Nel, Iseult Lynch
Summary: This article presents a technique for setting up detection limits on any fluorescent microscope using the fluorophore Nile Red for microplastic identification. It also introduces a morphology-specific identification key to reduce subjectivity among researchers. The method establishes detection limits for nine common polymer types and five natural substrates that could result in false-positive signals when using Nile Red. It is applied to real freshwater samples and validated by micro-FTIR or Raman spectroscopy, reducing subjectivity in microplastic identification and enhancing transparency, repeatability, and harmonization in the research community.
Article
Nanoscience & Nanotechnology
G. del Giudice, A. Serra, L. A. Saarimaeki, K. Kotsis, I. Rouse, S. A. Colibaba, K. Jagiello, A. Mikolajczyk, M. Fratello, A. G. Papadiamantis, N. Sanabria, M. E. Annala, J. Morikka, P. A. S. Kinaret, E. Voyiatzis, G. Melagraki, A. Afantitis, K. Taemm, T. Puzyn, M. Gulumian, V. Lobaskin, I. Lynch, A. Federico, D. Greco
Summary: By performing a meta-analysis of various engineered nanoparticle exposure studies, the authors identify common patterns of gene regulation that impact the transcriptomic response. Deregulation of immune functions is observed as a prominent response, with binding sites for zinc finger transcription factors C2H2 identified in the promoter regions of these genes. These findings suggest that the innate immune system has a conserved response to nanomaterials, potentially influenced by evolutionary exposure to natural nano-sized matter.
NATURE NANOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Mingshu Li, Li Gao, Jason C. White, Christy L. Haynes, Tana L. O'Keefe, Yukui Rui, Sami Ullah, Zhiling Guo, Iseult Lynch, Peng Zhang
Summary: Increasing the capacity of biological nitrogen fixation (BNF) is an effective strategy to enhance food security and reduce the carbon and nitrogen footprint of agriculture. Nanotechnology offers several pathways to successfully enhance BNF.
NATURE NANOTECHNOLOGY
(2023)
Article
Environmental Sciences
Patricia V. Silva, Catia S. A. Santos, Anastasios G. Papadiamantis, Sandra F. Goncalves, Marija Prodana, Rudo A. Verweij, Iseult Lynch, Cornelis A. M. van Gestel, Susana Loureiro
Summary: This study investigated the toxicokinetics of engineered nanoparticles in Chironomus riparius, showing that absorption of silver nanoparticles (Ag NPs) was higher in the simulating aged form (Ag2S NPs) compared to pristine Ag NPs and AgNO3. Water uptake was the main route of Ag accumulation, and chironomid larvae exhibited a strong ability to accumulate Ag. This is the first study on the toxicokinetics of nanoparticles in Chironomus, providing important insights into their exposure and interactions in the environment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Patricia V. Silva, Ana Rita R. Silva, Nathaniel J. Clark, Joanne Vassallo, Marta Baccaro, Neja Medve Scek, Magdalena Grgi, Abel Ferreira, Marti Busquets-Fite, Kerstin Jurkschat, Anastasios G. Papadiamantis, Victor Puntes, Iseult Lynch, Claus Svendsen, Nico W. van den Brink, Richard D. Handy, Cornelis A. M. van Gestel, Susana Loureiro
Summary: Mesocosms are useful for simulating realistic scenarios of organism exposure to nanoparticles. An indoor mesocosm experiment was conducted to assess the toxicokinetics and bioaccumulation of silver sulfide nanoparticles (Ag2S NPs) and AgNO3 in freshwater invertebrates. The study found that single-species tests could not reliably predict bioaccumulation in the more complex mesocosm scenario.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Multidisciplinary Sciences
Severin Wipf, Ruben Nitsche, David J. Burr, Andreas Elsaesser
Summary: Understanding the past and present habitability of Mars is important due to the evidence of liquid water and a warmer climate in the planet's history. There are minerals on Mars that suggest a more favorable environment for life in the past, leading to investigations of possible signs of extinct life. Earth-based experiments in Mars simulation facilities are essential to support missions studying Mars and test instruments.
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
(2023)
Review
Toxicology
Katie Reilly, Laura-Jayne A. Ellis, Hossein Hayat Davoudi, Suffeiya Supian, Marcella T. T. Maia, Gabriela H. H. Silva, Zhiling Guo, Diego Stefani T. Martinez, Iseult Lynch
Summary: The importance of Daphnia as a model organism for ecotoxicity testing has been established since the 1980s. The mapping of the genomes of Daphnia in recent years has further solidified their utility for ecotoxicity testing. However, the emergence of nanomaterials (NMs) has posed challenges to standard toxicity tests. Nonetheless, NM safety assessments have also driven innovations in toxicity testing approaches, including establishing more realistic environmental exposures and developing mechanistic insights.
FRONTIERS IN TOXICOLOGY
(2023)
Article
Ecology
Tahmina Yasmin, Megan A. Farrelly, Briony C. Rogers, Stefan Krause, Iseult Lynch
Summary: The paper discusses the growing call for adaptive governance approaches in urban water management systems and highlights the focus on evidence-based research in the Global North, while evidence from the Global South remains limited. The research conducted in two cities in Bangladesh examines how adaptive governance operates in different local contexts, and reveals that the larger urban system of Dhaka is currently experiencing lock-in due to various factors, while the smaller urban system of Mymensingh showcases enabling factors for sustainable growth. The study sheds light on the role of adaptive governance in relation to system scales, capacity, and key enabling attributes.
ECOLOGY AND SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Zhiling Guo, Peng Zhang, Changjian Xie, Evangelos Voyiatzis, Klaus Faserl, Andrew J. Chetwynd, Fazel Abdolahpur Monikh, Georgia Melagraki, Zhiyong Zhang, Willie J. G. M. Peijnenburg, Antreas Afantitis, Chunying Chen, Iseult Lynch
Summary: As antimicrobials, graphene materials (GMs) have potential advantages over traditional antibiotics due to their physical mechanisms of action, which reduce the chance of microbial resistance. This study shows that GMs with high surface oxygen content (SOC) primarily attach in parallel to the bacterial cell surface, while the interaction mode shifts to perpendicular when the SOC reaches a certain threshold. The rigidity of GMs is closely related to these distinct interaction modes. By understanding the interaction mode of GMs with bacteria, the antibacterial activity of GMs can be better understood.
