New polymyxin derivatives that display improved efficacy in animal infection models as compared to polymyxin B and colistin

Evaluation of colistin stability in agar and comparison of four methods for MIC testing of colistin

(2017) Agata Turlej-Rogacka et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016

(2017) Alessandra Carattoli et al.   Eurosurveillance

Resistance to polymyxins in Gram-negative organisms

(2017) Katy Jeannot et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections

(2017) Pamela Brown et al.   JOURNAL OF ANTIBIOTICS

The antibiotic resistance crisis, with a focus on the United States

(2017) Evan Martens et al.   JOURNAL OF ANTIBIOTICS

Polymyxin derivatives NAB739 and NAB815 are more effective than polymyxin B in murine Escherichia coli pyelonephritis

(2017) Martti Vaara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Plasmid-mediated or chromosomally mediated colistin resistance in Klebsiella pneumoniae ?

(2017) Alberto Antonelli et al.   LANCET INFECTIOUS DISEASES

Rediscovering the octapeptins

(2017) Tony Velkov et al.   NATURAL PRODUCT REPORTS

Recent advances and perspectives in the design and development of polymyxins

(2017) Francesc Rabanal et al.   NATURAL PRODUCT REPORTS

Structure–activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity

(2017) Martti Vaara et al.   PEPTIDES

Drug discovery strategies to outer membrane targets in Gram-negative pathogens

(2016) Dean G. Brown   BIOORGANIC & MEDICINAL CHEMISTRY

Treatment of Gram-negative bacterial infections by potentiation of antibiotics

(2016) Thomas P Zabawa et al.   CURRENT OPINION IN MICROBIOLOGY

Polymyxins: a new hope in combating Gram-negative superbugs?

(2016) Tony Velkov et al.   Future Medicinal Chemistry

Molecular mechanisms of polymyxin resistance: knowns and unknowns

(2016) Sophie Baron et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Synergistic combinations of polymyxins

(2016) Justin R. Lenhard et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Antimicrobial Resistance

(2016) Hilary D. Marston et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B

(2016) Alejandra Gallardo-Godoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Investigating Nephrotoxicity of Polymyxin Derivatives by Mapping Renal Distribution Using Mass Spectrometry Imaging

(2015) Anna Nilsson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Differences in potency and categorical agreement between colistin and polymyxin B when testing 15,377 clinical strains collected worldwide

(2015) Helio S. Sader et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

The safety of polymyxin antibiotics

(2015) Theodoros Kelesidis et al.   Expert Opinion On Drug Safety

Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of anmgrBDeletion Mutant

(2015) Tommaso Giani et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Polymyxin Combinations: Pharmacokinetics and Pharmacodynamics for Rationale Use

(2015) Phillip J. Bergen et al.   PHARMACOTHERAPY

Colistin: How should It Be Dosed for the Critically Ill?

(2015) Cornelia Landersdorfer et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

A bioinspired peptide scaffold with high antibiotic activity and low in vivo toxicity

(2015) Francesc Rabanal et al.   Scientific Reports

Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’

(2014) Tony Velkov et al.   ACS Chemical Biology

MgrB Inactivation Is a Common Mechanism of Colistin Resistance in KPC-Producing Klebsiella pneumoniae of Clinical Origin

(2014) Antonio Cannatelli et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese?

(2014) R. L. Nation et al.   CLINICAL INFECTIOUS DISEASES

Update on the antibiotic resistance crisis

(2014) Gian Maria Rossolini et al.   CURRENT OPINION IN PHARMACOLOGY

Discovery and development of new antibacterial agents targeting Gram-negative bacteria in the era of pandrug resistance: is the future promising?

(2014) Malcolm GP Page et al.   CURRENT OPINION IN PHARMACOLOGY

Cell- and biomarker-based assays for predicting nephrotoxicity

(2014) Johnny X Huang et al.   Expert Opinion on Drug Metabolism & Toxicology

Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates

(2014) Stephen A. Cochrane et al.   MEDICINAL RESEARCH REVIEWS

Adverse Reactions Associated with Systemic Polymyxin Therapy

(2014) Julie Ann Justo et al.   PHARMACOTHERAPY

The Renaissance of Polymyxins

(2013) B. Kadar et al.   CURRENT MEDICINAL CHEMISTRY

Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics

(2013) Deborah Burt et al.   DRUG AND CHEMICAL TOXICOLOGY

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

(2013) Zakuan Z Deris et al.   JOURNAL OF ANTIBIOTICS

Novel derivatives of polymyxins

(2013) M. Vaara   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovery of Dap-3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections

(2013) Thomas V. Magee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Early Prediction of Polymyxin-Induced Nephrotoxicity With Next-Generation Urinary Kidney Injury Biomarkers

(2013) Natalie D. Keirstead et al.   TOXICOLOGICAL SCIENCES

Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system

(2013) Edward J Kelly et al.   Stem Cell Research & Therapy

Rapid Killing of Acinetobacter baumannii by Polymyxins Is Mediated by a Hydroxyl Radical Death Pathway

(2012) Timothy R. Sampson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells

(2012) Martti Vaara et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Antimicrobial activity of the novel polymyxin derivative NAB739 tested against Gram-negative pathogens

(2012) M. Vaara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Population Pharmacokinetics of Colistin Methanesulfonate and Formed Colistin in Critically Ill Patients from a Multicenter Study Provide Dosing Suggestions for Various Categories of Patients

(2011) S. M. Garonzik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Colistin pharmacokinetics: the fog is lifting

(2011) W. Couet et al.   CLINICAL MICROBIOLOGY AND INFECTION

Impact of healthcare-associated acquisition on community-onset Gram-negative bloodstream infection: a population-based study

(2011) M. N. Al-Hasan et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Contemporary activity of colistin and polymyxin B against a worldwide collection of Gram-negative pathogens: results from the SENTRY Antimicrobial Surveillance Program (2006-09)

(2011) A. C. Gales et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Activity of Polymyxin B and the Novel Polymyxin Analogue CB-182,804 Against Contemporary Gram-Negative Pathogens in New York City

(2011) John Quale et al.   Microbial Drug Resistance

A Novel Polymyxin Derivative That Lacks the Fatty Acid Tail and Carries Only Three Positive Charges Has Strong Synergism with Agents Excluded by the Intact Outer Membrane

(2010) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Epidemiology, microbiology and outcomes of healthcare-associated and community-acquired bacteremia: A multicenter cohort study

(2010) Marin H. Kollef et al.   JOURNAL OF INFECTION

Contribution of Each Amino Acid Residue in Polymyxin B3 to Antimicrobial and Lipopolysaccharide Binding Activity

(2009) Kazushi Kanazawa et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration

(2009) F. E. A. Ali et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents

(2008) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients

(2008) Alexandre P. Zavascki et al.   CLINICAL INFECTIOUS DISEASES