Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections

Multicenter Prospective Cohort Study of Renal Failure in Patients Treated with Colistin versus Polymyxin B

(2016) Maria Helena Rigatto et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B

(2016) Alejandra Gallardo-Godoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

An improved and efficient strategy for the total synthesis of a colistin-like peptide

(2016) Suhas Ramesh et al.   TETRAHEDRON LETTERS

Major Pathways of Polymyxin-Induced Apoptosis in Rat Kidney Proximal Tubular Cells

(2015) Mohammad A. K. Azad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The safety of polymyxin antibiotics

(2015) Theodoros Kelesidis et al.   Expert Opinion On Drug Safety

Antimicrobial Peptides with Potential for Biofilm Eradication: Synthesis and Structure Activity Relationship Studies of Battacin Peptides

(2015) Gayan Heruka De Zoysa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus

(2015) Roger L Nation et al.   LANCET INFECTIOUS DISEASES

Polymyxin Combinations: Pharmacokinetics and Pharmacodynamics for Rationale Use

(2015) Phillip J. Bergen et al.   PHARMACOTHERAPY

A new strategy for total solid-phase synthesis of polymyxins

(2015) Wei-Liang Xu et al.   TETRAHEDRON LETTERS

Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’

(2014) Tony Velkov et al.   ACS Chemical Biology

In Vitro Assessment and Multicenter Cohort Study of Comparative Nephrotoxicity Rates Associated with Colistimethate versus Polymyxin B Therapy

(2014) K. Phe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Probing the Penetration of Antimicrobial Polymyxin Lipopeptides into Gram-Negative Bacteria

(2014) Zakuan Z. Deris et al.   BIOCONJUGATE CHEMISTRY

Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese?

(2014) R. L. Nation et al.   CLINICAL INFECTIOUS DISEASES

Adverse Reactions Associated with Systemic Polymyxin Therapy

(2014) Julie Ann Justo et al.   PHARMACOTHERAPY

Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria

(2014) Abiola O. Olaitan et al.   Frontiers in Microbiology

New Dosing Strategies for an Old Antibiotic: Pharmacodynamics of Front-Loaded Regimens of Colistin at Simulated Pharmacokinetics in Patients with Kidney or Liver Disease

(2013) Gauri G. Rao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Renaissance of Polymyxins

(2013) B. Kadar et al.   CURRENT MEDICINAL CHEMISTRY

Antimicrobial susceptibility of Gram-negative organisms isolated from patients hospitalized in intensive care units in United States and European hospitals (2009–2011)

(2013) Helio S. Sader et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Pharmacology of polymyxins: new insights into an ‘old’ class of antibiotics

(2013) Tony Velkov et al.   Future Microbiology

Novel derivatives of polymyxins

(2013) M. Vaara   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovery of Dap-3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections

(2013) Thomas V. Magee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Early Prediction of Polymyxin-Induced Nephrotoxicity With Next-Generation Urinary Kidney Injury Biomarkers

(2013) Natalie D. Keirstead et al.   TOXICOLOGICAL SCIENCES

The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells

(2012) Martti Vaara et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Antimicrobial activity of the novel polymyxin derivative NAB739 tested against Gram-negative pathogens

(2012) M. Vaara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells

(2012) Marie-Paule Mingeot-Leclercq et al.   PEPTIDES

Battacin (Octapeptin B5), a New Cyclic Lipopeptide Antibiotic from Paenibacillus tianmuensis Active against Multidrug-Resistant Gram-Negative Bacteria

(2011) Chao-Dong Qian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Des-Fatty Acyl-Polymyxin B Derivatives with Pseudomonas aeruginosa-Specific Antimicrobial Activity

(2011) Yuki Sato et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Paenibacillus polymyxa PKB1 Produces Variants of Polymyxin B-Type Antibiotics

(2011) Mohamed Shaheen et al.   CHEMISTRY & BIOLOGY

Activity of Polymyxin B and the Novel Polymyxin Analogue CB-182,804 Against Contemporary Gram-Negative Pathogens in New York City

(2011) John Quale et al.   Microbial Drug Resistance

A Novel Polymyxin Derivative That Lacks the Fatty Acid Tail and Carries Only Three Positive Charges Has Strong Synergism with Agents Excluded by the Intact Outer Membrane

(2010) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polymyxins and their novel derivatives

(2010) Martti Vaara   CURRENT OPINION IN MICROBIOLOGY

The impact of polymyxin B dosage on in-hospital mortality of patients treated with this antibiotic

(2010) L. S. Elias et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structure–activity studies on novel polymyxin derivatives that carry only three positive charges

(2010) Martti Vaara et al.   PEPTIDES

Resurgence of Colistin: A Review of Resistance, Toxicity, Pharmacodynamics, and Dosing

(2010) Lauren M Lim et al.   PHARMACOTHERAPY

Development of Des-Fatty Acyl-Polymyxin B Decapeptide Analogs with Pseudomonas aeruginosa-Specific Antimicrobial Activity

(2009) Naoko Katsuma et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Contribution of Each Amino Acid Residue in Polymyxin B3 to Antimicrobial and Lipopolysaccharide Binding Activity

(2009) Kazushi Kanazawa et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration

(2009) F. E. A. Ali et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Interactions of Lipopolysaccharide and Polymyxin Studied by NMR Spectroscopy

(2009) Jiri Mares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure−Activity Relationships of Polymyxin Antibiotics

(2009) Tony Velkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents

(2008) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polymyxins Revisited

(2008) D. Landman et al.   CLINICAL MICROBIOLOGY REVIEWS