A bioinspired peptide scaffold with high antibiotic activity and low in vivo toxicity

Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’

(2014) Tony Velkov et al.   ACS Chemical Biology

Uptake of Polymyxin B into Renal Cells

(2014) Kamilia Abdelraouf et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiotic resistance sweeping developing world

(2014) Sara Reardon   NATURE

A three-step plan for antibiotics

(2014)   NATURE

Policy: An intergovernmental panel on antimicrobial resistance

(2014) Mark Woolhouse et al.   NATURE

ND4BB: addressing the antimicrobial resistance crisis

(2014) John H. Rex   NATURE REVIEWS MICROBIOLOGY

10 x '20 Progress--Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America

(2013) H. W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

(2013) Zakuan Z Deris et al.   JOURNAL OF ANTIBIOTICS

Antibiotics in the clinical pipeline in 2013

(2013) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

Prospects for new antibiotics: a molecule-centered perspective

(2013) Christopher T Walsh et al.   JOURNAL OF ANTIBIOTICS

Novel derivatives of polymyxins

(2013) M. Vaara   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovery of Dap-3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections

(2013) Thomas V. Magee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disturbing pacemakers, and other stories

(2013)   BMJ-British Medical Journal

Pharmacokinetics and Renal Disposition of Polymyxin B in an Animal Model

(2012) Kamilia Abdelraouf et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Peptide–Drug Conjugate Linked via a Disulfide Bond for Kidney Targeted Drug Delivery

(2012) Qian Geng et al.   BIOCONJUGATE CHEMISTRY

Emerging Themes and Therapeutic Prospects for Anti-Infective Peptides

(2011) Nannette Y. Yount et al.   Annual Review of Pharmacology and Toxicology

First Description of an Escherichia coli Strain Producing NDM-1 Carbapenemase in Spain

(2011) Mar Solé et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Combating Antimicrobial Resistance: Policy Recommendations to Save Lives

(2011)   CLINICAL INFECTIOUS DISEASES

Antimicrobial peptides: key components of the innate immune system

(2011) Mukesh Pasupuleti et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Characterization of in Vivo Disulfide-Reduction Mediated Drug Release in Mouse Kidneys

(2011) Jun J. Yang et al.   MOLECULAR PHARMACEUTICS

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

Biodegradable nanostructures with selective lysis of microbial membranes

(2011) Fredrik Nederberg et al.   Nature Chemistry

The 10 × ‘20 Initiative: Pursuing a Global Commitment to Develop 10 New Antibacterial Drugs by 2020

(2010)   CLINICAL INFECTIOUS DISEASES

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

Polymyxin B Identified as an Inhibitor of Alternative NADH Dehydrogenase and Malate: Quinone Oxidoreductase from the Gram-positive Bacterium Mycobacterium smegmatis

(2009) T. Mogi et al.   JOURNAL OF BIOCHEMISTRY

Structure−Activity Relationships of Polymyxin Antibiotics

(2009) Tony Velkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Broad-Spectrum Antimicrobial Peptides by Rational Combinatorial Design and High-Throughput Screening: The Importance of Interfacial Activity

(2009) Ramesh Rathinakumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY