Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21
出版年份 2015 全文链接
标题
Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21
作者
关键词
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出版物
Science Signaling
Volume 8, Issue 402, Pages ra113-ra113
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2015-11-11
DOI
10.1126/scisignal.aab3715
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
- (2014) K. R. Markan et al. DIABETES
- Silencing of FGF-21 expression promotes hepatic gluconeogenesis and glycogenolysis by regulation of the STAT3-SOCS3 signal
- (2014) Cong Wang et al. FEBS Journal
- Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21
- (2014) M. Cornu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine
- (2013) Susanne Keipert et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy
- (2013) Perrine Castets et al. Cell Metabolism
- An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
- (2013) William L. Holland et al. Cell Metabolism
- The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
- (2013) Gregory Gaich et al. Cell Metabolism
- Fibroblast Growth Factor 21 (FGF21) and Glucagon-Like Peptide 1 Contribute to Diabetes Resistance in Glucagon Receptor-Deficient Mice
- (2013) B. A. Omar et al. DIABETES
- Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
- (2013) R. M. Young et al. GENES & DEVELOPMENT
- Increased Expression of Fibroblast Growth Factor 21 (FGF21) during Chronic Undernutrition Causes Growth Hormone Insensitivity in Chondrocytes by Inducing Leptin Receptor Overlapping Transcript (LEPROT) and Leptin Receptor Overlapping Transcript-like 1 (LEPROTL1) Expression
- (2013) Shufang Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FGF21 contributes to neuroendocrine control of female reproduction
- (2013) Bryn M Owen et al. NATURE MEDICINE
- FGF21 regulates metabolism and circadian behavior by acting on the nervous system
- (2013) Angie L Bookout et al. NATURE MEDICINE
- Adipose tissue browning and metabolic health
- (2013) Alexander Bartelt et al. Nature Reviews Endocrinology
- Expression of Fibroblast Growth Factor-21 in Muscle Is Associated with Lipodystrophy, Insulin Resistance and Lipid Disturbances in Patients with HIV
- (2013) Birgitte Lindegaard et al. PLoS One
- Ketone bodies as signaling metabolites
- (2013) John C. Newman et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Clinical and Experimental Applications of Sodium Phenylbutyrate
- (2013) Tommaso Iannitti et al. Drugs in research & development
- Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy
- (2013) C Bentzinger et al. Skeletal Muscle
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum
- (2012) S Varadarajan et al. CELL DEATH AND DIFFERENTIATION
- Circulating Fibroblast Growth Factors as Metabolic Regulators—A Critical Appraisal
- (2012) Bo Angelin et al. Cell Metabolism
- Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
- (2012) Asami Hagiwara et al. Cell Metabolism
- βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism
- (2012) Xunshan Ding et al. Cell Metabolism
- FGF21 regulates PGC-1 and browning of white adipose tissues in adaptive thermogenesis
- (2012) f. M. Fisher et al. GENES & DEVELOPMENT
- Transient Low-Dose Methotrexate Induces Tolerance to Murine Anti-Thymocyte Globulin and Together They Promote Long-Term Allograft Survival
- (2012) A. Joseph et al. JOURNAL OF IMMUNOLOGY
- The Rab GTPase-Activating Protein TBC1D4/AS160 Contains an Atypical Phosphotyrosine-Binding Domain That Interacts with Plasma Membrane Phospholipids To Facilitate GLUT4 Trafficking in Adipocytes
- (2012) S.-X. Tan et al. MOLECULAR AND CELLULAR BIOLOGY
- Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
- (2012) Kook Hwan Kim et al. NATURE MEDICINE
- Muscles, exercise and obesity: skeletal muscle as a secretory organ
- (2012) Bente K. Pedersen et al. Nature Reviews Endocrinology
- The unfolded protein response: controlling cell fate decisions under ER stress and beyond
- (2012) Claudio Hetz NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor
- (2012) W. Wei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival
- (2012) F. J. Ramos et al. Science Translational Medicine
- Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
- (2012) Christian Appenzeller-Herzog et al. TRENDS IN CELL BIOLOGY
- The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
- (2012) Yuan Zhang et al. eLife
- An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and 3T3-L1 adipocytes
- (2011) Kumiko Saito et al. ANALYTICAL BIOCHEMISTRY
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
- (2011) Timothy R. Peterson et al. CELL
- Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
- (2011) Jessica L. Yecies et al. Cell Metabolism
- Akt Determines Cell Fate Through Inhibition of the PERK-eIF2 Phosphorylation Pathway
- (2011) Z. Mounir et al. Science Signaling
- Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients
- (2010) Pere Domingo et al. AIDS
- Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat
- (2010) Elayne Hondares et al. Cell Metabolism
- Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
- (2010) Patrick Seale et al. JOURNAL OF CLINICAL INVESTIGATION
- NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse
- (2009) Owen P. McGuinness et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
- (2009) R. A. DeFronzo et al. DIABETES CARE
- Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity
- (2009) Eric D. Berglund et al. ENDOCRINOLOGY
- Fibroblast Growth Factor 21 Reduces the Severity of Cerulein-Induced Pancreatitis in Mice
- (2009) Charis L. Johnson et al. GASTROENTEROLOGY
- Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
- (2009) Valérie Risson et al. JOURNAL OF CELL BIOLOGY
- FGF21 induces PGC-1 and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
- (2009) M. J. Potthoff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21
- (2008) Takeshi Inagaki et al. Cell Metabolism
- Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
- (2008) Pazit Polak et al. Cell Metabolism
- Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
- (2008) C. Florian Bentzinger et al. Cell Metabolism
- Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
- (2008) J. Xu et al. DIABETES
- FGF21 is an Akt-regulated myokine
- (2008) Yasuhiro Izumiya et al. FEBS LETTERS
- Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
- (2008) Inki Kim et al. NATURE REVIEWS DRUG DISCOVERY
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