Impact of DNA and RNA Methylation on Radiobiology and Cancer Progression

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

(2018) Mengnuo Chen et al.   HEPATOLOGY

Roles of Long Noncoding RNAs in Recurrence and Metastasis of Radiotherapy-Resistant Cancer Stem Cells

(2017) Hsiang-Cheng Chi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Dark Side of the Epitranscriptome: Chemical Modifications in Long Non-Coding RNAs

(2017) Roland Jacob et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications

(2017) Isabelle R. Miousse et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

MicroRNA-145 ModulatesN6-Methyladenosine Levels by Targeting the 3′-Untranslated mRNA Region of theN6-Methyladenosine Binding YTH Domain Family 2 Protein

(2017) Zhe Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia

(2017) Chau-To Kwok et al.   Journal of Hematology & Oncology

Epigenetics in cancer stem cells

(2017) Tan Boon Toh et al.   Molecular Cancer

Regulation of m 6 A Transcripts by the 3ʹ→5ʹ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline

(2017) Magdalena Natalia Wojtas et al.   MOLECULAR CELL

Corrigendum: Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2017) Xiang Wang et al.   NATURE

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

(2017) Yang Xiang et al.   NATURE

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

(2017) Isaia Barbieri et al.   NATURE

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

(2017) Ly P Vu et al.   NATURE MEDICINE

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

(2017) A Visvanathan et al.   ONCOGENE

ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells

(2017) Chong Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combinatorial effects of an epigenetic inhibitor and ionizing radiation contribute to targeted elimination of pancreatic cancer stem cell

(2017) Hyun-Mi Kwon et al.   Oncotarget

The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma

(2017) Xiao Li et al.   Oncotarget

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated

(2016) Atsushi Tanabe et al.   CANCER LETTERS

METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing

(2016) Jin-zhao Ma et al.   HEPATOLOGY

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

(2016) Ping Wang et al.   MOLECULAR CELL

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

m6A-LAIC-seq reveals the census and complexity of the m6A epitranscriptome

(2016) Benoit Molinie et al.   NATURE METHODS

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies

(2016) Elisabetta Fratta et al.   Oncotarget

Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells

(2016) Chuanzhao Zhang et al.   Oncotarget

Structural insights into the molecular mechanism of the m6A writer complex

(2016) Paweł Śledź et al.   eLife

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

International Variation in Female Breast Cancer Incidence and Mortality Rates

(2015) C. E. DeSantis et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors

(2015) Xiaofei Chen et al.   Epigenetics

International Variations and Trends in Renal Cell Carcinoma Incidence and Mortality

(2015) Ariana Znaor et al.   EUROPEAN UROLOGY

A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation

(2015) Shengdong Ke et al.   GENES & DEVELOPMENT

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification

(2015) Caroline Roost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

Epigenetic treatment of solid tumours: a review of clinical trials

(2015) Clara Nervi et al.   Clinical Epigenetics

DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study

(2015) Hon-Yi Lin et al.   Oncotarget

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells

(2014) Pedro J. Batista et al.   Cell Stem Cell

Crystal structure of the RNA demethylase ALKBH5 from zebrafish

(2014) Weizhong Chen et al.   FEBS LETTERS

Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-strandedN6-Methyladenosine RNA Demethylation

(2014) Chao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of the Human RNA Demethylase Alkbh5 Reveal Basis for Substrate Recognition

(2014) Chong Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of microRNA-24 and DNA Methylation in Resistance of Nasopharyngeal Carcinoma to Ionizing Radiation

(2014) S. Wang et al.   MOLECULAR CANCER THERAPEUTICS

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

(2014) Yang Wang et al.   NATURE CELL BIOLOGY

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

(2014) Chao Xu et al.   Nature Chemical Biology

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation

(2014) WeiShen Aik et al.   NUCLEIC ACIDS RESEARCH

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

(2014) Yue Huang et al.   NUCLEIC ACIDS RESEARCH

Increased P16 DNA Methylation in Mouse Thymic Lymphoma Induced by Irradiation

(2014) Wengang Song et al.   PLoS One

Epigenetics in radiotherapy: Where are we heading?

(2014) Kim M. Smits et al.   RADIOTHERAPY AND ONCOLOGY

Reading RNA methylation codes through methyl-specific binding proteins

(2014) Xiao Wang et al.   RNA Biology

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

Epigenetic therapy of acute myeloid leukemia using 5-aza-2'-deoxycytidine (decitabine) in combination with inhibitors of histone methylation and deacetylation

(2014) Richard L Momparler et al.   Clinical Epigenetics

Genomic Analysis as the First Step toward Personalized Treatment in Renal Cell Carcinoma

(2014) Zofia Felicja Bielecka et al.   Frontiers in Oncology

Radiation-induced epigenetic DNA methylation modification of radiation-response pathways

(2013) Deborah A Antwih et al.   Epigenetics

Epidemiology of Malignant Cervical, Corpus Uteri and Ovarian Tumours - Current Data and Epidemiological Trends

(2013) A. Waldmann et al.   GEBURTSHILFE UND FRAUENHEILKUNDE

Epigenetics Meets Radiation Biology as a New Approach in Cancer Treatment

(2013) Joong-Gook Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle

(2013) Keiko Horiuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia

(2013) Maria E. Figueroa et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetics Meets Genetics in Acute Myeloid Leukemia: Clinical Impact of a Novel Seven-Gene Score

(2013) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes

(2013) Roberto Gomez-Casal et al.   Molecular Cancer

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA

(2013) Ye Fu et al.   Nature Communications

Oncogenic Isocitrate Dehydrogenase Mutations: Mechanisms, Models, and Clinical Opportunities

(2013) R. A. Cairns et al.   Cancer Discovery

Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma

(2013) Christopher J Ricketts et al.   Clinical Epigenetics

DNA Methylation Biomarkers Offer Improved Diagnostic Efficiency in Lung Cancer

(2012) G. Nikolaidis et al.   CANCER RESEARCH

Methylation status of O6-methylguanine-DNA-methyl transferase promoter region in non-small-cell lung cancer patients with brain metastasis

(2012) Kenji Hashimoto et al.   Clinical & Translational Oncology

Aberrant Promoter Methylation of CDH13 and MGMT Genes is Associated With Clinicopathologic Characteristics of Primary Non–Small-Cell Lung Carcinoma

(2012) Milica Kontic et al.   Clinical Lung Cancer

DNMTs are required for delayed genome instability caused by radiation

(2012) Christine A. Armstrong et al.   Epigenetics

Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

(2012) Baoen Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Individualization of cancer treatment from radiotherapy perspective

(2012) Ala Yaromina et al.   Molecular Oncology

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

FET-PET assessed recurrence pattern after radio-chemotherapy in newly diagnosed patients with glioblastoma is influenced by MGMT methylation status

(2012) Maximilian Niyazi et al.   RADIOTHERAPY AND ONCOLOGY

Reversible RNA adenosine methylation in biological regulation

(2012) Guifang Jia et al.   TRENDS IN GENETICS

RNA Methylation by the MIS Complex Regulates a Cell Fate Decision in Yeast

(2012) Sudeep D. Agarwala et al.   PLoS Genetics

N6-methyl-adenosine (m6A) in RNA: An Old Modification with A Novel Epigenetic Function

(2012) Yamei Niu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma

(2011) Lian Shu Piao et al.   CANCER LETTERS

Epigenetic-Based Therapies in Cancer

(2011) Sang-Hyun Song et al.   DRUGS

Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: a systematic review and meta-analysis

(2011) Robert A. Olson et al.   JOURNAL OF NEURO-ONCOLOGY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma

(2011) A. L. Rivera et al.   NEURO-ONCOLOGY

Cyclosporin A Associated Helicase-Like Protein Facilitates the Association of Hepatitis C Virus RNA Polymerase with Its Cellular Cyclophilin B

(2011) Kengo Morohashi et al.   PLoS One

Molecular and translational radiation biology/oncology: What’s up?

(2011) H. Peter Rodemann et al.   RADIOTHERAPY AND ONCOLOGY

DNA methylation changes in cells regrowing after fractioned ionizing radiation

(2011) Christine Kuhmann et al.   RADIOTHERAPY AND ONCOLOGY

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

CD44 Expression Predicts Local Recurrence after Radiotherapy in Larynx Cancer

(2010) M. C. de Jong et al.   CLINICAL CANCER RESEARCH

Pancreatic Cancer Cells Resistant to Chemoradiotherapy Rich in “Stem-Cell-Like” Tumor Cells

(2010) Zhiyong Du et al.   DIGESTIVE DISEASES AND SCIENCES

Radiation-induced genomic instability: Are epigenetic mechanisms the missing link?

(2010) Umut Aypar et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Impact of Genomic Methylation on Radiation Sensitivity of Colorectal Carcinoma

(2010) Barbara Hofstetter et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation

(2010) Giovanni L Gravina et al.   Molecular Cancer

Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model

(2010) Igor Koturbash et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Global analysis of CpG methylation reveals epigenetic control of the radiosensitivity in lung cancer cell lines

(2010) E-H Kim et al.   ONCOGENE

Selective targeting of radiation-resistant tumor-initiating cells

(2010) Mei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First report on the patient database for the identification of the genetic pathways involved in patients over-reacting to radiotherapy: GENEPI-II

(2010) Dirk De Ruysscher et al.   RADIOTHERAPY AND ONCOLOGY

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

(2009) J. W. Vardiman et al.   BLOOD

Genetic variants and normal tissue toxicity after radiotherapy: A systematic review

(2009) Christian Nicolaj Andreassen et al.   RADIOTHERAPY AND ONCOLOGY

DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells

(2008) Hong Qiu et al.   CANCER SCIENCE

Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming

(2008) Rudolf Jaenisch et al.   CELL

Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner

(2008) Yaroslav Ilnytskyy et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

(2008) Guifang Jia et al.   FEBS LETTERS

Correlation of O6-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT Activity

(2008) Monika E. Hegi et al.   JOURNAL OF CLINICAL ONCOLOGY

Genetic variation in normal tissue toxicity induced by ionizing radiation

(2008) Odilia Popanda et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

MTA Is an Arabidopsis Messenger RNA Adenosine Methylase and Interacts with a Homolog of a Sex-Specific Splicing Factor

(2008) S. Zhong et al.   PLANT CELL

Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner

(2008) S. R. Nallagatla et al.   RNA