Article
Biochemistry & Molecular Biology
Cherie-Ann Nathan, Alok R. Khandelwal, Gregory T. Wolf, Juan P. Rodrigo, Antti A. Makitie, Nabil F. Saba, Arlene A. Forastiere, Carol R. Bradford, Alfio Ferlito
Summary: This review summarizes the current evidence and impact of TP53 mutations in head and neck squamous cell carcinomas (HNSCC), including their association with tumor invasion, metastasis, genomic instability, and cell proliferation, as well as their link to increased aggressiveness and reduced survival after surgical treatment of HNSCC.
MOLECULAR CARCINOGENESIS
(2022)
Article
Plant Sciences
Rui-Yi Yang, Jia-Yi Tan, Zhe Liu, Xiao-Ling Shen, Ying-Jie Hu
Summary: The natural lignan LAF from Arctium lappa Linne has been found to inhibit tumor cell growth in vitro and in vivo. However, its role in cell cycle regulation remains unknown.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Medicine, General & Internal
Kuiwei Su, Ying Wang, Hefeng Gu, Lan Ma, Guihong Xuan
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common malignancy worldwide. This study investigated the expression and impact of FADS3 in HNSCC, and found that high expression of FADS3 is associated with poor prognosis, lymph node metastasis, histologic grade, and lymphovascular invasion. FADS3 is also related to inhibition of amino acid metabolism and reduced levels of B cells.
Article
Medicine, General & Internal
Zelong Yang, Yang Han, Guo Ting, Yifei Wang, He Kun, Haoran Hu, Chen Yong
Summary: High CCNF expression serves as an independent risk factor for poor survival in HCC and may be a potential target for the diagnosis and treatment of liver cancer.
Article
Cell Biology
Yuanbo Hu, Chenbin Chen, Xinya Tong, Sian Chen, Xianjing Hu, Bujian Pan, Xiangwei Sun, Zhiyuan Chen, Xinyu Shi, Yingying Hu, Xian Shen, Xiangyang Xue, Mingdong Lu
Summary: NSUN2, a m5C RNA methyltransferase, is upregulated in gastric cancer (GC) and predicts poor prognosis. It promotes cell proliferation, migration, and invasion, possibly through direct interaction with SUMO-2/3 for nuclear transport. NSUN2 is involved in multiple cancer-related signaling pathways, with potential target genes such as PIK3R1 and PCYT1A in GC progression.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Masakazu Toi, Kenichi Inoue, Norikazu Masuda, Hiroji Iwata, Joohyuk Sohn, In Hae Park, Seock-Ah Im, Shin-Cheh Chen, Sotaro Enatsu, P. Kellie Turner, Valerie A. M. Andre, Molly C. Hardebeck, Sachi Sakaguchi, Matthew P. Goetz, George W. Sledge
Summary: In East Asian patients with HR+, HER2- advanced breast cancer, abemaciclib in combination with ET demonstrated significantly prolonged progression-free survival, with generally tolerable safety profiles. Pharmacokinetics were similar between East Asians and non-East Asians in both MONARCH 2 and MONARCH 3 trials.
Article
Genetics & Heredity
Nozomi Tanaka, Chikashi Minemura, Shunichi Asai, Naoko Kikkawa, Takashi Kinoshita, Sachi Oshima, Ayaka Koma, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa, Naohiko Seki
Summary: The miR-199 family acts as tumor-suppressive miRNAs in head and neck squamous cell carcinoma by regulating the expression of paxillin (PXN) which contributes to cancer cell aggressiveness.
Article
Oncology
Masato Takahashi, Eriko Tokunaga, Joji Mori, Yoshinori Tanizawa, Jan-Stefan Van der Walt, Tsutomu Kawaguchi, Matthew P. Goetz, Masakazu Toi
Summary: In the Japanese subpopulation, abemaciclib plus NSAI was shown to be an effective initial treatment for ABC, with a manageable safety profile, consistent with findings in the overall population.
Article
Oncology
Kenichi Inoue, Norikazu Masuda, Hiroji Iwata, Masato Takahashi, Yoshinori Ito, Yasuo Miyoshi, Takahiro Nakayama, Hirofumi Mukai, Jan-Stefan van der Walt, Joji Mori, Sachi Sakaguchi, Tsutomu Kawaguchi, Yoshinori Tanizawa, Antonio Llombart-Cussac, George W. Sledge, Masakazu Toi
Summary: In the Japanese subpopulation analysis of the MONARCH 2 study, abemaciclib plus fulvestrant demonstrated significantly prolonged progression-free survival, higher objective response rate, and good safety profile in treating advanced breast cancer patients. Results were consistent with those of the overall population.
Article
Oncology
Katerina Smesny Trtkova, Petra Luzna, Denisa Weiser Drozdkova, Katerina Cizkova, Lucie Janovska, Jan Gursky, Dana Prukova, Ivo Frydrych, Marian Hajduch, Jiri Minarik
Summary: This study examined the role of gene inactivation and gene expression regulation in multiple myeloma and found that treatment with SBHA and DAC can significantly influence the transcription and molecular behavior of CDKN2A, CDKN2B, and CDKN1A genes.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Multidisciplinary Sciences
Hanqiang Deng, Elizabeth Min, Nicolas Baeyens, Brian G. Coon, Rui Hu, Zhen W. Zhuang, Minghao Chen, Billy Huang, Titilayo Afolabi, Georgia Zarkada, Angela Acheampong, Kathleen McEntee, Anne Eichmann, Fang Liu, Bing Su, Michael Simons, Martin A. Schwartz
Summary: This study investigates the sensing of fluid shear stress by endothelial cells. Low shear stress triggers inward remodeling to restore normal levels, while high shear stress is suppressed. The findings suggest that low shear stress activates the Smad2/3 pathway, while high shear stress blocks Smad2/3 nuclear translocation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Medicinal
Belen Martinez-Gualda, Sirle Saul, Mathy Froeyen, Dominique Schols, Piet Herdewijn, Shirit Einav, Steven De Jonghe
Summary: Inserting a carboxamide residue at position 3 of the scaffold can generate potent GAK inhibitors with antiviral activity against dengue virus.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Joyce O'Shaughnessy, Adam Brufsky, Hope S. Rugo, Sara M. Tolaney, Kevin Punie, Sagar Sardesai, Erika Hamilton, Delphine Loirat, Tiffany Traina, Roberto Leon-Ferre, Sara A. Hurvitz, Kevin Kalinsky, Aditya Bardia, Stephanie Henry, Ingrid Mayer, Yanni Zhu, See Phan, Javier Cortes
Summary: This study analyzed the efficacy of sacituzumab govitecan in patients with metastatic triple-negative breast cancer (mTNBC). The results showed that regardless of whether patients had TNBC at initial diagnosis, sacituzumab govitecan improved clinical outcomes. For patients without TNBC at initial diagnosis, the clinical efficacy and safety of sacituzumab govitecan were manageable.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Chemistry, Organic
Davit Hayrapetyan, Valeriya Stepanova
Summary: In this study, spirocyclic pyrrolidones and piperidones were synthesized via [3+2]- and [3+3]-aza-annulation reactions starting from readily available alpha-ketolactones and alpha-ketolactams. The annulation reactions proceeded with good yields and excellent diastereoselectivity, creating one C-C and two C-N bonds, as well as three new stereocenters in a fast and efficient manner.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Oncology
Satu Pallasaho, Aishwarya Gondane, Anni Kuivalainen, Samuel Girmay, Siver Moestue, Massimo Loda, Harri M. Itkonen
Summary: The study reveals that CDK7 and CDK9 are highly active in castration-resistant prostate cancer (CRPC) cells, and inhibiting these kinases can effectively suppress the proliferation of CRPC cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Qi Liu, Luis Palomero, Jade Moore, Ines Guix, Roderic Espin, Alvaro Aytes, Jian-Hua Mao, Amanda G. Paulovich, Jeffrey R. Whiteaker, Richard G. Ivey, George Iliakis, Daxian Luo, Anthony J. Chalmers, John Murnane, Miquel Angel Pujana, Mary Helen Barcellos-Hoff
Summary: The study reveals that TGF-beta signaling controls genomic stability by regulating the DNA damage response and inhibiting Alt-EJ gene expression. Tumors classified as low TGF-beta and high Alt-EJ show more genomic alterations and increased sensitivity to genotoxic therapy, suggesting potential therapeutic implications for targeting these pathways in cancer treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biology
Rabina Mainali, Manal Zabalawi, David Long, Nancy Buechler, Ellen Quillen, Chia-Chi Key, Xuewei Zhu, John S. Parks, Cristina Furdui, Peter W. Stacpoole, Jennifer Martinez, Charles E. McCall, Matthew A. Quinn
Summary: Metabolic reprogramming occurs in the immune system during sepsis, particularly in the liver, with changes in lipid metabolism, mitochondrial energy, and redox balance. Targeting mitochondrial energy metabolism can rebalance the transcriptional and metabolic manifestations of sepsis in the liver.
Article
Biochemistry & Molecular Biology
John A. Collins, Maryna Kapustina, Jesalyn A. Bolduc, James F. W. Pike, Brian O. Diekman, Kimberlee Mix, Susan Chubinskaya, Emrah Eroglu, Thomas Michel, Leslie B. Poole, Cristina M. Furdui, Richard F. Loeser
Summary: SIRT6, a nuclear localized deacetylase protein, is a critical regulator of aging processes. It can promote resistance to oxidative stress and influences specific members of the Prx catalytic cycle in chondrocytes to maintain redox homeostasis. Age and oxidative stress conditions alter SIRT6 activity, suggesting potential therapeutic targets for maintaining redox balance in joint tissues and preventing osteoarthritis progression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Andy T. Kwok, Nequesha S. Mohamed, Johannes F. Plate, Raghunatha R. Yammani, Samuel Rosas, Ted A. Bateman, Eric Livingston, Joseph E. Moore, Bethany A. Kerr, Jingyun Lee, Cristina M. Furdui, Li Tan, Mary L. Bouxsein, Virginia L. Ferguson, Louis S. Stodieck, David C. Zawieja, Michael D. Delp, Xiao W. Mao, Jeffrey S. Willey
Summary: Reduced weight-bearing from spaceflight or hind limb unloading induced arthritic changes in cartilage and menisci, but exercise promoted recovery.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jing Su, Qianqian Song, Shadi Qasem, Stacey O'Neill, Jingyun Lee, Cristina M. Furdui, Boris Pasche, Linda Metheny-Barlow, Adrianna H. Masters, Hui-Wen Lo, Fei Xing, Kounosuke Watabe, Lance D. Miller, Stephen B. Tatter, Adrian W. Laxton, Christopher T. Whitlow, Michael D. Chan, Michael H. Soike, Jimmy Ruiz
Summary: This study used a multi-omics approach to characterize brain metastasis and identified two molecular subtypes with significantly different prognoses, revealing key pathways and metabolites. The results indicated that the immune microenvironment landscape and proliferation and migration signaling pathways may contribute to the observed survival differences, providing an opportunity to identify clinically impactful biomarkers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Brittany C. Lipchick, Adam Utley, Zhannan Han, Sudha Moparthy, Dong Hyun Yun, Anna Bianchi-Smiraglia, David W. Wolff, Emily Fink, Liang Liu, Cristina M. Furdui, Jingyun Lee, Kelvin P. Lee, Mikhail A. Nikiforov
Summary: This study identified the role of lipid metabolism in the resistance of multiple myeloma cells to the proteasome inhibitor bortezomib. Lower levels of fatty acid elongase 6 (ELOVL6) were found in bortezomib-nonresponsive MM cells compared to bortezomib-responsive cells. Restoring ELOVL6 levels resensitized resistant cells by upregulating ceramide species, essential for bortezomib-induced endoplasmic reticulum stress and cell death.
Article
Biochemistry & Molecular Biology
Kuanlin Wu, Hanzhi Wu, Wanqing Lyu, Youngjoo Kim, Cristina M. Furdui, Karen S. Anderson, Anthony J. Koleske
Summary: Abl family kinases are nonreceptor tyrosine kinases that are activated by phosphorylation upon interaction with PDGFR beta. Specific tyrosine residues play a crucial role in this phosphorylation process, leading to enhanced kinase activity and activation of Abl family kinases.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Oncology
Christina M. Snyder, Monica M. Rohde, Cale D. Fahrenholtz, Jessica Swanner, John Sloop, George L. Donati, Cristina M. Furdui, Ravi Singh
Summary: The study shows that silver nanoparticles can selectively kill mesenchymal triple-negative breast cancer cells by causing lipid and protein oxidation, without harming normal cells. This suggests that stratification of TNBC subtypes may improve outcomes for other therapeutics with similar mechanisms.
Article
Oncology
Kimberly M. Burcher, Andrew T. Faucheux, Jeffrey W. Lantz, Harper L. Wilson, Arianne Abreu, Kiarash Salafian, Manisha J. Patel, Alexander H. Song, Robin M. Petro, Thomas Lycan, Cristina M. Furdui, Umit Topaloglu, Ralph B. D'Agostino, Wei Zhang, Mercedes Porosnicu
Summary: The study found that DDR gene mutations are significantly increased in older patients, patients with primary tumors in the larynx, patients with advanced stage cancer at diagnosis, and patients previously treated with chemotherapy and/or radiotherapy in head and neck squamous cell cancer (HNSCC). Patients with primary tumors in the oropharynx are less likely to have DDR gene mutations. DDR gene mutations identified in blood samples were associated with worse survival outcomes. The study highlights the importance of DDR gene mutations in HNSCC and supports further research on PARP inhibitors in precision oncology treatments.
Article
Oncology
Jade Moore, Lin Ma, Ann A. Lazar, Mary Helen Barcellos-Hoff
Summary: In breast cancer, the distribution of infiltrating immune cells is associated with clinical outcome. Tumors with abundant tumor-infiltrating lymphocytes are more likely to respond to immunotherapy, while those without or with excluded CD8 T cells are less likely to respond. However, the understanding of this biology is limited due to a lack of preclinical breast cancer models that recapitulate the distribution of tumor-infiltrating lymphocytes.
Article
Biochemistry & Molecular Biology
Nicole P. Kasica, Xueyan Zhou, Qian Yang, Xin Wang, Wenzhong Yang, Helena R. Zimmermann, Caroline E. Holland, Elizabeth Koscielniak, Hanzhi Wu, Anderson O. Cox, Jingyun Lee, Alexey G. Ryazanov, Cristina M. Furdui, Tao Ma
Summary: This study demonstrates the therapeutic potential of inhibiting eEF2K kinase in improving synaptic plasticity impairments and cognitive dysfunction in AD model mice.
JOURNAL OF NEUROCHEMISTRY
(2022)
Review
Oncology
Qi Liu, Genwen Chen, Jade Moore, Ines Guix, Dimitris Placantonakis, Mary Helen Barcellos-Hoff
Summary: TGF-β is a crucial factor in influencing cancer cell phenotypes, tumor microenvironment, and the immune response to cancer therapy. However, the diverse mechanisms by which TGF-β inhibits therapeutic response pose a challenge in targeting TGF-β for cancer treatment. Developing companion diagnostic tools and specific biomarkers will be key in utilizing TGF-β biology for patient benefit.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Xiaofei Chen, Zhe Li, Caigang Zhu, Kirtikar Shukla, Tom E. Forshaw, Hanzhi Wu, Stephen A. Vance, Megan Madonna, Mark W. Dewhirst, Allen W. Tsang, Leslie B. Poole, Nimmi Ramanujam, Cristina M. Furdui, Kiran Kumar Solingapuram Sai, Buddhika Liyana Pathirannahel, S. Bruce King
Summary: Redox metabolism plays a crucial role in cancer and other diseases. This study presents a new radiotracer for in vivo imaging of protein oxidation, which has the potential for diagnosing tumors.
Article
Multidisciplinary Sciences
Diego R. Coelho, Flavio R. Palma, Veronica Paviani, Chenxia He, Jeanne M. Danes, Yunping Huang, Juliana C. P. Calado, Peter C. Hart, Cristina M. Furdui, Leslie B. Poole, Matthew J. Schipma, Marcelo G. Bonini
Summary: Acetylation of SOD2 changes its biochemical function from an antioxidant to a demethylase, promoting stem cell gene expression and contributing to tumor progression and metastasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemical Research Methods
Reetta Holmila, Hanzhi Wu, Jingyun Lee, Allen W. Tsang, Ravi Singh, Cristina M. Furdui
Summary: This study reveals that silver nanoparticles induce changes in protein abundance and reversible oxidation in a time and cell-line-dependent manner, impacting critical cellular processes with mitochondria as a main target. The mitochondrial networks and morphology in Calu-1 and NCI-H358 lung cells are differentially affected by AgNPs toxicity.
MOLECULAR & CELLULAR PROTEOMICS
(2021)
