Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1

(2017) Erkin Erdal et al.   GENES & DEVELOPMENT

Cyclic GMP–AMP Synthase Is the Cytosolic Sensor ofPlasmodium falciparumGenomic DNA and Activates Type I IFN in Malaria

(2017) Carolina Gallego-Marin et al.   JOURNAL OF IMMUNOLOGY

Intracellular DNA sensing pathway of cGAS-cGAMP is decreased in human newborns and young children

(2017) Zhan-sheng Wang et al.   MOLECULAR IMMUNOLOGY

Investigations on the molecular mode of action of the novel immunostimulator ZelNate: Activation of the cGAS-STING pathway in mammalian cells

(2017) Thomas Ilg   MOLECULAR IMMUNOLOGY

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

(2017) Nagaraj Kerur et al.   NATURE MEDICINE

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

(2017) Jessica Vincent et al.   Nature Communications

Hydroxybenzylidene-indolinones, c-di-AMP synthase inhibitors, have antibacterial and anti-biofilm activities and also re-sensitize resistant bacteria to methicillin and vancomycin

(2017) Clement Opoku-Temeng et al.   RSC Advances

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

(2017) Justin Hall et al.   PLoS One

Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A

(2017) Peijun Ren et al.   Scientific Reports

Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin

(2016) Clement Opoku-Temeng et al.   CHEMICAL COMMUNICATIONS

Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase

(2016) Ruchi Jain Dey et al.   Nature Chemical Biology

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Suramin inhibits cullin-RING E3 ubiquitin ligases

(2016) Kenneth Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins

(2016) Baoyu Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cutting Edge: Antimalarial Drugs Inhibit IFN-β Production through Blockade of Cyclic GMP-AMP Synthase–DNA Interaction

(2015) Jie An et al.   JOURNAL OF IMMUNOLOGY

cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response toFrancisellaInfection

(2015) Kelly M. Storek et al.   JOURNAL OF IMMUNOLOGY

Positive Feedback Regulation of Type I IFN Production by the IFN-Inducible DNA Sensor cGAS

(2015) Feng Ma et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

(2015) Elizabeth E. Gray et al.   JOURNAL OF IMMUNOLOGY

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay

(2014) Yue Zheng et al.   CHEMICAL COMMUNICATIONS

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

(2013) Xin Li et al.   IMMUNITY

Adenovirus Detection by the cGAS/STING/TBK1 DNA Sensing Cascade

(2013) E. Lam et al.   JOURNAL OF VIROLOGY

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

STING-dependent cytosolic DNA sensing pathways

(2013) Glen N. Barber   TRENDS IN IMMUNOLOGY

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

(2013) Philip J. Kranzusch et al.   Cell Reports

Rare Variants in theTREX1Gene and Susceptibility to Autoimmune Diseases

(2013) Nadia Barizzone et al.   Biomed Research International

An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology

(2013) Rojo A. Ratsimandresy et al.   Frontiers in Immunology

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

Dominant Mutations of the TREX1 Exonuclease Gene in Lupus and Aicardi-Goutières Syndrome

(2011) Jason M. Fye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

(2011) Fuguo Jiang et al.   NATURE

Interferon-β is a key regulator of proinflammatory events in experimental autoimmune encephalomyelitis

(2010) CL Galligan et al.   Multiple Sclerosis Journal

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL