期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 19, 页码 3754-3757出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc10446g
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资金
- National Science Foundation [CHE1307218]
- Camille Dreyfus Foundation
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1636752] Funding Source: National Science Foundation
C-di-AMP synthases are essential in several bacteria, including human pathogens; hence these enzymes are potential antibiotic targets. However, there is a dearth of small molecule inhibitors of c-di-AMP metabolism enzymes. Screening of 2000 known drugs against DisA has led to the identification of suramin, an antiparasitic drug as potent inhibitor of c-di-AMP synthase.
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