期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 76, 页码 11234-11237出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc02916j
关键词
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资金
- NSF [CHE 1307218]
- Camille Dreyfus foundation
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1307218] Funding Source: National Science Foundation
c-di-AMP is an important bacterial second messenger found in Gram-positive and mycobacteria. c-di-AMP regulates myriads of processes in bacteria as well as immune response in higher organisms so interest in small molecules that would attenuate the activity of c-di-AMP metabolism enzymes is high. Herein, we report the first small molecule inhibitor of a c-di-AMP synthase, DisA, using a coralyne-based assay.
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