Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

(2014) Li Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents

(2014) Frank T. Zindo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

(2014) Oscar M. Bautista-Aguilera et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases

(2013) Pierre Koch et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of monoamine oxidase by phthalide analogues

(2013) Belinda Strydom et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and studies of calcium channel blocking and antioxidant activities of novel 4-pyridinium and/or N-propargyl substituted 1,4-dihydropyridine derivatives

(2013) Martins Rucins et al.   COMPTES RENDUS CHIMIE

Istradefylline: First Global Approval

(2013) Rosselle Dungo et al.   DRUGS

Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: Synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study

(2013) Maria J. Matos et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Promises of novel multi-target neuroprotective and neurorestorative drugs for Parkinson's disease

(2013) Moussa B.H. Youdim et al.   PARKINSONISM & RELATED DISORDERS

Monoamine Oxidase Inhibitors and Neuroprotection

(2012) Saleem K. Al-Nuaimi et al.   AMERICAN JOURNAL OF THERAPEUTICS

The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease

(2012) Lana Kupershmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

Polycyclic Cage Structures as Lipophilic Scaffolds for Neuroactive Drugs

(2012) Jacques Joubert et al.   ChemMedChem

Ladostigil: A Novel Multimodal Neuroprotective Drug with Cholinesterase and Brain-Selective Monoamine Oxidase Inhibitory Activities for Alzheimers Disease Treatment

(2012) Orly Weinreb et al.   CURRENT DRUG TARGETS

Adenosine A2A Antagonists in Parkinson’s Disease: What’s Next?

(2012) Patrick Hickey et al.   Current Neurology and Neuroscience Reports

Propargylamine-derived multitarget-directed ligands: fighting Alzheimer’s disease with monoamine oxidase inhibitors

(2012) Irene Bolea et al.   JOURNAL OF NEURAL TRANSMISSION

Multi-target, Neuroprotective and Neurorestorative M30 Improves Cognitive Impairment and Reduces Alzheimer's-Like Neuropathology and Age-Related Alterations in Mice

(2012) Lana Kupershmidt et al.   MOLECULAR NEUROBIOLOGY

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities

(2011) Eva Torres et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer’s disease

(2011) Abdelouahid Samadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Future Treatments for Parkinson's Disease: Surfing the PD Pipeline

(2011) Robert A. Hauser   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil andN-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

(2011) Irene Bolea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

(2011) Rafael León et al.   MEDICINAL RESEARCH REVIEWS

Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain

(2011) L. Kupershmidt et al.   NEUROSCIENCE

Neuroprotective Multifunctional Iron Chelators: From Redox-Sensitive Process to Novel Therapeutic Opportunities

(2010) Orly Weinreb et al.   ANTIOXIDANTS & REDOX SIGNALING

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles

(2010) Abdelouahid Samadi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In Vivo Characterization of a Dual Adenosine A2A/A1Receptor Antagonist in Animal Models of Parkinson’s Disease

(2010) Brian C. Shook et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rasagiline: A novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity

(2010) Orly Weinreb et al.   PROGRESS IN NEUROBIOLOGY

New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities

(2009) María D. Duque et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Alzheimer's disease mitochondrial cascade hypothesis: An update

(2009) Russell H. Swerdlow et al.   EXPERIMENTAL NEUROLOGY

Synthesis of Dihydrofuroaporphine Derivatives: Identification of a Potent and Selective Serotonin 5-HT1AReceptor Agonist

(2009) Zhili Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adenosine A2Areceptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms

(2008) Liqun Yu et al.   ANNALS OF NEUROLOGY

A novel adenosine A1 and A2A receptor antagonist ASP5854 ameliorates motor impairment in MPTP-treated marmosets: Comparison with existing anti-Parkinson's disease drugs

(2008) Takuma Mihara et al.   BEHAVIOURAL BRAIN RESEARCH

Synergistic effects of selegiline and donepezil on cognitive impairment induced by amyloid beta (25–35)

(2008) H TSUNEKAWA et al.   BEHAVIOURAL BRAIN RESEARCH

Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs

(2008) Pelayo Camps et al.   BIOORGANIC & MEDICINAL CHEMISTRY

N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility

(2008) Seetal Dodd et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells

(2008) Elisenda Sanz et al.   JOURNAL OF NEUROCHEMISTRY

Multifunctional neuroprotective derivatives of rasagiline as anti-alzheimer’s disease drugs

(2008) Orly Weinreb et al.   Neurotherapeutics

Dual-target-directed drugs that block monoamine oxidase B and adenosine A2A receptors for Parkinson’s disease

(2008) Jacobus P. Petzer et al.   Neurotherapeutics

Neuroprotection in mice by NGP1-01 after transient focal brain ischemia

(2007) Jiukuan Hao et al.   BRAIN RESEARCH