Article
Chemistry, Medicinal
Juyoung Jung, Yoonsuk Lee, An-Na Moon, Jihyae Ann, Jin Ju Jeong, Nayeon Do, Jeewoo Lee
Summary: This study synthesized new compounds and discovered one compound with potential for treating Parkinson's disease, showing good pharmacokinetic properties and low safety risk in vivo.
Article
Biochemistry & Molecular Biology
Anup Masih, Amol K. Agnihotri, Jitendra K. Srivastava, Nidhi Pandey, Hans R. Bhat, Udaya P. Singh
Summary: Parkinson's disease is characterized by motor and nonmotor impairments, and there is growing interest in adenosine A(2)A receptor antagonists for relief in PD. In this study, novel 1,3,5-triazines were developed and shown to act as A(2)AR antagonists through cell testing and molecular docking analysis, exhibiting promising potential for treatment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Clinical Neurology
Tetsuya Maeda, Takashi Kimura, Kenichiro Sugiyama, Kana Yamada, Ren Hiraiwa, Masato Nishi, Nobutaka Hattori
Summary: KW-6356 monotherapy is well tolerated and more effective than placebo in patients with early, untreated PD.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Ramesh Pariyar, Tonking Bastola, Dae Ho Lee, Jungwon Seo
Summary: The anti-diabetic drug vildagliptin has been found to have protective effects against motor dysfunction caused by Parkinson's disease (PD), potentially through the regulation of PI3k/Akt, ERK, and JNK signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Xiao-Le Wang, Si-Tong Feng, Bin Chen, Die Hu, Zhen-Zhen Wang, Yi Zhang
Summary: In this study, the effects of istradefylline on treating the motor symptoms of Parkinson's disease (PD) patients were re-evaluated. The results showed that istradefylline exhibited significant efficacy in improving motor symptoms compared to placebo, with no significant difference in tolerability and adverse effects.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Xuenan Wang, Min Li, Jinlu Xie, Dadian Chen, Xiwen Geng, Shuang Sun, Bo Liu, Min Wang
Summary: Beta band hypersynchrony within the basal ganglia-thalamocortical network has been suggested as a hallmark of Parkinson's disease. Abnormal beta band oscillations are correlated with dopamine depletion and can be regulated by dopamine D2 receptors.
BRAIN RESEARCH BULLETIN
(2022)
Article
Plant Sciences
Qingyu Ren, Xin Jiang, Yam Nath Paudel, Xin Gao, Daili Gao, Pengyu Zhang, Wenlong Sheng, Xueliang Shang, Kechun Liu, Xiujun Zhang, Meng Jin
Summary: The co-treatment of GL alleviates apoptosis and autophagy and suppresses inflammatory responses in a MPTP-induced PD-like condition in zebrafish.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Neurosciences
Robert A. Hauser, Nobutaka Hattori, Hubert Fernandez, Stuart H. Isaacson, Hideki Mochizuki, Olivier Rascol, Fabrizio Stocchi, June Li, Akihisa Mori, Yu Nakajima, Robert Ristuccia, Peter LeWitt
Summary: Istradefylline significantly improved OFF time and ON-WoTD in patients with Parkinson's disease, and was well-tolerated in clinical studies.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Neurosciences
Cynthia Kwan, Imane Frouni, Stephen G. Nuara, Sebastien Belliveau, Woojin Kang, Adjia Hamadjida, Dominique Bedard, Francis Beaudry, Michel Panisset, Jim C. Gourdon, Philippe Huot
Summary: The study demonstrated that concurrent antagonising of 5-HT2A and activation of mGlu(2) receptors could provide greater anti-dyskinetic and anti-psychotic effects than either approach alone. Additionally, mGlu(2) activation may enhance the therapeutic effects of 5-HT2A blockade, potentially offering relief beyond current therapies for PD patients with dyskinesia and psychotic symptoms.
Article
Biochemistry & Molecular Biology
Sandra Duperrier, Analia Bortolozzi, Veronique Sgambato
Summary: Parkinson's disease (PD) is characterized by cell loss in the substantia nigra and the presence of alpha-synuclein-containing neuronal Lewy bodies. This study investigated the expression levels of alpha-, beta-, and gamma-synucleins in brainstem regions involved in PD physiopathology. The results showed increased expression of these synucleins in the PD model macaques, which correlated with cell loss and motor score.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Manuj Ahuja, Navneet Ammal Kaidery, Otis C. Attucks, Erin McDade, Dmitry M. Hushpulian, Arsen Gaisin, Irina Gaisina, Young Hoon Ahn, Sergey Nikulin, Andrey Poloznikov, Irina Gazaryan, Masayuki Yamamoto, Mitsuyo Matsumoto, Kazuhiko Igarashi, Sudarshana M. Sharma, Bobby Thomas
Summary: Research suggests that genetic deletion or pharmacologic inhibition of Bach1 could be a promising therapeutic approach for Parkinson's disease, offering neuroprotection and reducing oxidative damage and neuroinflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Taku Hatano, Osamu Kano, Renpei Sengoku, Asako Yoritaka, Keisuke Suzuki, Noriko Nishikawa, Yohei Mukai, Kyoichi Nomura, Norihito Yoshida, Morinobu Seki, Miho Kawabe Matsukawa, Hiroo Terashi, Katsuo Kimura, Jun Tashiro, Shigeki Hirano, Hidetomo Murakami, Hideto Joki, Tsuyoshi Uchiyama, Hideki Shimura, Kotaro Ogaki, Jiro Fukae, Yoshio Tsuboi, Kazushi Takahashi, Toshimasa Yamamoto, Naotake Yanagisawa, Hiroshi Nagayama
Summary: The ISTRA ADJUST PD study aims to evaluate the effect of adjunctive istradefylline on levodopa dosage titration in PD patients. The study plans to recruit 100 evaluable patients for efficacy analysis by February 2022, with the goal of determining whether istradefylline can reduce the cumulative additional dose of levodopa-containing medications in PD patients experiencing the wearing-off phenomenon and lower the risk of levodopa-associated complications.
Article
Biochemistry & Molecular Biology
Jannis Achenbach, Andreas Matusch, David Elmenhorst, Andreas Bauer, Carsten Saft
Summary: This study evaluates the effects of caffeine consumption on Huntington's Disease (HD) and finds that consuming more than 3 cups of caffeine per day has beneficial effects on neuropsychological performance, onset of symptoms, and disease progression in manifest HD patients. However, there are no improvements in neuropsychological performance for premanifest HD mutation carriers, and they even show worse cognitive performances and more severe signs of psychiatric impairment. Further studies are needed to validate these findings and test for dosage related effects.
Article
Cell Biology
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Summary: The transcription factor TFE3 has been found to play a crucial role in maintaining autophagy and the survival of dopaminergic neurons in Parkinson's disease. Activation of TFE3 may serve as a promising strategy for PD therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Ziying Wang, Jinshuai Cui, Dongni Li, Shuzhen Ran, Junqing Huang, Gang Chen
Summary: In this study, a natural compound called morin was found to promote mitophagy and have therapeutic effects on a Parkinson's disease mouse model. Morin acts by activating the AMPK-ULK1 pathway and promoting nuclear translocation of the mitophagy regulator TFEB. This research lays the foundation for the potential use of morin as a clinical drug for Parkinson's disease treatment.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)