Propargylamine-derived multitarget-directed ligands: fighting Alzheimer’s disease with monoamine oxidase inhibitors

Patent-related survey on new monoamine oxidase inhibitors and their therapeutic potential

(2012) Simone Carradori et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Rosiglitazone Does Not Improve Cognition or Global Function when Used as Adjunctive Therapy to AChE Inhibitors in Mild-to-Moderate Alzheimers Disease: Two Phase 3 Studies

(2011) C. Harrington et al.   Current Alzheimer Research

Combination Treatment in Alzheimers Disease: Results of a Randomized, Controlled Trial with Cerebrolysin and Donepezil

(2011) X. A. Alvarez et al.   Current Alzheimer Research

Lights and Shadows on Monoamine Oxidase Inhibition in Neuroprotective Pharmacological Therapies

(2011) Claudia Binda et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Combination Therapy for Alzheimerʼs Disease

(2011) Laxeshkumar Patel et al.   DRUGS & AGING

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil andN-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

(2011) Irene Bolea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans

(2011) William Cho et al.   PSYCHOPHARMACOLOGY

Alzheimer's disease - input of vitamin D with mEmantine assay (AD-IDEA trial): study protocol for a randomized controlled trial

(2011) Cédric Annweiler et al.   Trials

Site-Activated Chelators Targeting Acetylcholinesterase and Monoamine Oxidase for Alzheimer’s Therapy

(2010) Hailin Zheng et al.   ACS Chemical Biology

Novel Huprine Derivatives with Inhibitory Activity toward β-Amyloid Aggregation and Formation as Disease-Modifying Anti-Alzheimer Drug Candidates

(2010) Elisabet Viayna et al.   ChemMedChem

The economic impact of dementia in Europe in 2008-cost estimates from the Eurocode project

(2010) A. Wimo et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Amyloid-β-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Aβ peptide. Implications for the pathogenesis of Alzheimer's disease

(2010) Margarita C Dinamarca et al.   Molecular Neurodegeneration

Oxidative stress in Alzheimer disease

(2010) Alejandro Gella et al.   Cell Adhesion & Migration

Depression and Alzheimer's disease: Neurobiological links and common pharmacological targets

(2009) Filippo Caraci et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Alzheimer's disease mitochondrial cascade hypothesis: An update

(2009) Russell H. Swerdlow et al.   EXPERIMENTAL NEUROLOGY

The Frequency of Cognitive Impairment in Patients With Anxiety, Depression, and Bipolar Disorder

(2009) C. Thomas Gualtieri et al.   JOURNAL OF CLINICAL PSYCHIATRY

Site-Activated Multifunctional Chelator with Acetylcholinesterase and Neuroprotective−Neurorestorative Moieties for Alzheimer’s Therapy

(2009) Hailin Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] confers MAO-B independent neuroprotection in ER stress-induced cell death

(2009) Elisenda Sanz et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Increased Neurofibrillary Tangles in Patients With Alzheimer Disease With Comorbid Depression

(2008) Michael A. Rapp et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Synergistic effects of selegiline and donepezil on cognitive impairment induced by amyloid beta (25–35)

(2008) H TSUNEKAWA et al.   BEHAVIOURAL BRAIN RESEARCH

Synthesis and Biological Evaluation of NO-Donor-Tacrine Hybrids as Hepatoprotective Anti-Alzheimer Drug Candidates

(2008) Lei Fang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells

(2008) Elisenda Sanz et al.   JOURNAL OF NEUROCHEMISTRY

Memoquin: A multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer’s disease

(2008) Maria Laura Bolognesi et al.   Neurotherapeutics

Targeting multiple Alzheimer’s disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

(2007) Tamar Amit et al.   FASEB JOURNAL