Review
Medicine, Research & Experimental
Jian Zhang, Hai Zhao, Gang Yao, Penghai Qiao, Longfei Li, Shuguang Wu
Summary: Iron is an essential trace element for living organisms, but iron overload can lead to osteoporosis. Iron chelators have therapeutic effects on iron overload-induced osteoporosis and may also be used for treating bone loss caused by other factors. Iron chelators have different effects on bone cells, stimulating osteogenic differentiation in osteoblast lineage cells and inhibiting osteoclast differentiation. Antioxidant capability and fibroblast growth factor 23 are also involved in the osteoprotective effects of iron chelators.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Robert Gawecki, Jaroslaw Polanski, Anna Mrozek-Wilczkiewicz
Summary: Photodynamic therapy is a patient-friendly and promising anticancer treatment that enhances the oxygen-triggered phototoxic reaction. The concentration of protoporphyrin IX, the active ingredient, can be increased by using iron chelators. In this study, a thiosemicarbazone derivative was found to universally enhance the phototoxic effect. Despite the presence of elevated ABCG2 levels responsible for PpIX efflux, the concentration in the cell was sufficient to trigger the photodynamic reaction. This effect was not observed with 5-ALA alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Jasmin Portelinha, Searle S. Duay, Seung Yu, Kara Heilemann, M. Daben J. Libardo, Samuel A. Juliano, Jonathan L. Klassen, Alfredo M. Angeles-Boza
Summary: Antimicrobial peptides (AMPs) are a promising platform for developing novel classes of antibiotics to combat new pathogens and multidrug resistant bacteria. A subclass of AMPs known as ATCUN-AMPs utilize the inherent toxicity of copper ions for a synergistic effect against pathogens. Common structural features in ATCUN-AMPs and their molecular mechanisms are important areas of study for understanding their antimicrobial activity.
Article
Pharmacology & Pharmacy
Reza Karimi-Soflou, Akbar Karkhaneh
Summary: This study successfully prepared a targeted intracellular doxorubicin delivery system based on redox-sensitive hyaluronic acid-palmitoyl (HA-ss-PA) copolymers, showing good drug loading capacity and encapsulation efficiency, and inducing apoptosis in tumor cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Charlene B. Van Buiten, Guojun Wu, Yan Y. Lam, Liping Zhao, Ilya Raskin
Summary: Fe0 treatment reduces luminal ROS in the gastrointestinal tract, improves metabolic outcomes in obese and hyperglycemic animals, promotes the growth of beneficial bacteria, and suppresses detrimental populations.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Efthalia Angelopoulou, Yam Nath Paudel, Christina Piperi, Awanish Mishra
Summary: Cinnamon may have neuroprotective effects against Parkinson's disease by regulating autophagy, antioxidant effects, and influencing dopaminergic cell death, among other mechanisms.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Efthalia Angelopoulou, Yam N. Paudel, Christina Piperi, Awanish Mishra
Summary: Cinnamon may have neuroprotective effects in neurodegenerative diseases, including Parkinson's disease. In vitro studies have shown that essential oils of cinnamon species can protect cells from oxidative stress, reactive oxygen species, and autophagy dysregulation, while in vivo studies have demonstrated that oral administration of cinnamon powder and sodium benzoate can protect against dopaminergic cell death and motor deficits.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Engineering, Chemical
Xiande Xie, Jingxia Li, Jing Liu, Zhuo Chen, Xiaoqing Yuan, Tao Chen, Lin Luo
Summary: Chromium picolinate (Cr(pic)3), widely used in animal feeding, can be introduced to the environment through animal waste, leading to chromium contamination risk. Direct adsorption and precipitation methods for removing chromium in Cr(pic)3 form are difficult. This study investigated the treatment of Cr(pic)3 using the Fenton process and found that it can effectively degrade Cr(pic)3 and remove chromium simultaneously, making it promising for treating Cr(pic)3-containing wastewater.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Haoqin Fan, Fan Yang, Zhenghui Xiao, Haiyan Luo, Huaiyang Chen, Zhi Chen, Qiming Liu, Yunbin Xiao
Summary: Lactate, traditionally considered a metabolic waste, has been found to have metabolic and nonmetabolic functions in physiological processes and diseases such as cancer and pulmonary arterial hypertension. This is due to metabolic reprogramming and epigenetic modifications, particularly histone modifications caused by lactate-induced posttranslational modifications. The cross talk between the metabolome and epigenome indicates potential for novel epigenetic regulatory and therapeutic opportunities, but further research is needed to understand lactylation mechanisms and its diverse biological effects.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Matthew K. Boag, Linlin Ma, George D. Mellick, Dean L. Pountney, Yunjiang Feng, Ronald J. Quinn, Alan Wee-Chung Liew, Mahendiran Dharmasivam, Mahan Gholam Azad, Rizwana Afroz, Des R. Richardson
Summary: The study focuses on the role of Ca(V)1.3 channels in calcium and iron uptake, and proposes the potential of using artificial intelligence to design novel channel inhibitors to alleviate PD pathology.
Review
Endocrinology & Metabolism
Ying Yao, Bin Wang, Yanbiao Jiang, Hong Guo, Yulan Li
Summary: Ferroptosis is a regulated form of cell death that is mainly associated with iron-driven lipid peroxidation damage. It is regulated by iron homeostasis, redox balance, lipid metabolism, glutathione metabolism, and various disease signaling pathways. The occurrence of Ferroptosis has both hidden dangers and advantages in ovary diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Usama Abbasi, Srinivas Abbina, Arshdeep Gill, Lily E. Takuechi, Jayachandran N. Kizhakkedathu
Summary: This article discusses the essential role of iron in the human body, the importance of iron homeostasis, and the effects of iron deficiency and excess on the body. It also explores the use of iron chelation strategies in alleviating the toxicity of excess iron.
ACS CHEMICAL BIOLOGY
(2021)
Article
Environmental Sciences
Yawen Yuan, Shutong Chen, Bin Yao, Anwei Chen, Liang Pei, Si Luo, Yaoyu Zhou
Summary: A Fe3+/persulfate system enhanced with a natural ligand cysteine was employed for the degradation of quinclorac, which widened the effective pH range and increased the removal rate for quinclorac. The mechanism was revealed that the Fe3+/Cys/PS system can enhance the ability of degrading quinclorac by accelerating the Fe3+/Fe2+ redox cycle and generating more reactive oxygen species. The impact factors were also optimized. This study provides a promising strategy for organic contaminated water remediation with high catalytic activity and wide pH tolerance.
ENVIRONMENTAL RESEARCH
(2023)
Review
Immunology
Stephan von Gunten, Christoph Schneider, Lejla Imamovic, Guy Gorochov
Summary: Significant progress has been made in understanding human antibody repertoires, including non-canonical functions of antibodies. Polyclonal immunoglobulin preparations, such as IVIG and SCIG, are crucial for antibody replacement therapy. Recent evidence suggests that pooled IgA may promote healthy gut microbiota colonization in mucosal IgA immunodeficiency. Plasma-derived polyclonal IgG and IgA have immunoregulatory effects, inspiring the development of novel drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Yongfeng Chen, Jing Li, Zhiqiang Zhao
Summary: Recent studies have shown that redox dysregulation plays a significant role in the development and progression of acute lymphoblastic leukemia (ALL). Pro-oxidant therapy targeting redox dysregulation has shown promising results in treating ALL patients, but drug resistance and side effects remain major challenges. Oxidative stress can activate antioxidant mechanisms in leukemia cells to escape damage, while also causing harm to hematopoietic stem cells.