标题
The role of mass spectrometry in the characterization of biologic protein products
作者
关键词
-
出版物
Expert Review of Proteomics
Volume 15, Issue 5, Pages 431-449
出版商
Informa UK Limited
发表日期
2018-04-26
DOI
10.1080/14789450.2018.1469982
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Direct Liquid Chromatography/Mass Spectrometry Analysis for Complete Characterization of Recombinant Adeno-Associated Virus Capsid Proteins
- (2017) Xiaoying Jin et al. Human Gene Therapy Methods
- Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control
- (2017) Yubo Tang et al. Scientific Reports
- Structural analysis of small to medium-sized molecules by mass spectrometry after electron-ion fragmentation (ExD) reactions
- (2016) Yulin Qi et al. ANALYST
- The use of generic surrogate peptides for the quantitative analysis of human immunoglobulin G1 in pre-clinical species with high-resolution mass spectrometry
- (2016) Christian Lanshoeft et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification–Structure–Function Correlations by Hydrogen–Deuterium Exchange Mass Spectrometry
- (2016) Yuetian Yan et al. ANALYTICAL CHEMISTRY
- Antibody-drug conjugates—an emerging class of cancer treatment
- (2016) Nikolaos Diamantis et al. BRITISH JOURNAL OF CANCER
- Characterization of antibody–drug conjugates by mass spectrometry: advances and future trends
- (2016) Richard Y.-C. Huang et al. DRUG DISCOVERY TODAY
- N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins
- (2016) Fabian Higel et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Intact mass analysis of monoclonal antibodies by capillary electrophoresis—Mass spectrometry
- (2016) Mei Han et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- A Retrospective Evaluation of the Use of Mass Spectrometry in FDA Biologics License Applications
- (2016) Sarah Rogstad et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Evaluation of Ion Mobility-Mass Spectrometry for Comparative Analysis of Monoclonal Antibodies
- (2016) Carly N. Ferguson et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- FPOP-LC-MS/MS Suggests Differences in Interaction Sites of Amphipols and Detergents with Outer Membrane Proteins
- (2016) Thomas G. Watkinson et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry
- (2016) Richard Y.-C. Huang et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Oxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodies
- (2016) Tetyana Dashivets et al. mAbs
- Simultaneous monitoring of oxidation, deamidation, isomerization, and glycosylation of monoclonal antibodies by liquid chromatography-mass spectrometry method with ultrafast tryptic digestion
- (2016) Yi Wang et al. mAbs
- Full validation of therapeutic antibody sequences by middle-up mass measurements and middle-down protein sequencing
- (2016) Anja Resemann et al. mAbs
- Six alternative proteases for mass spectrometry–based proteomics beyond trypsin
- (2016) Piero Giansanti et al. Nature Protocols
- Fast separation and analysis of reduced monoclonal antibodies with capillary zone electrophoresis coupled to mass spectrometry
- (2016) Yimeng Zhao et al. TALANTA
- Hybridizing LBA with LC–MS/MS: the new norm for biologics quantification
- (2016) Suma Ramagiri et al. Bioanalysis
- Quantitative Host Cell Protein Analysis Using Two Dimensional Data Independent LC–MSE
- (2015) Amy Farrell et al. ANALYTICAL CHEMISTRY
- Collision Induced Unfolding of Intact Antibodies: Rapid Characterization of Disulfide Bonding Patterns, Glycosylation, and Structures
- (2015) Yuwei Tian et al. ANALYTICAL CHEMISTRY
- Comparability of Biosimilar Filgrastim with Originator Filgrastim: Protein Characterization, Pharmacodynamics, and Pharmacokinetics
- (2015) Fritz Sörgel et al. BIODRUGS
- Peptide therapeutics: current status and future directions
- (2015) Keld Fosgerau et al. DRUG DISCOVERY TODAY
- An overview of FDA-approved biologics medicines
- (2015) Michael S. Kinch DRUG DISCOVERY TODAY
- Enhancing protein disulfide bond cleavage by UV excitation and electron capture dissociation for top-down mass spectrometry
- (2015) Piriya Wongkongkathep et al. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
- Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC–MS/MS approach: Assay development, validation, and a case study
- (2015) Ang Liu et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies
- (2015) Alain Beck et al. JOURNAL OF MASS SPECTROMETRY
- Comparison of Traditional 2-AB Fluorescence LC–MS/MS and Automated LC–MS for the Comparative Glycan Analysis of Monoclonal Antibodies
- (2015) John E. Schiel et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice
- (2015) Michaela Aichler et al. LABORATORY INVESTIGATION
- Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics
- (2015) Richard S Rogers et al. mAbs
- Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 2: Mass spectrometric methods
- (2015) Dietmar Reusch et al. mAbs
- Glycan analysis of therapeutic glycoproteins
- (2015) Lei Zhang et al. mAbs
- DIA mass spectrometry
- (2015) Allison Doerr NATURE METHODS
- Identification in drug quality control and drug research
- (2015) Sándor Görög TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- Evolutionary Constraint and Disease Associations of Post-Translational Modification Sites in Human Genomes
- (2015) Jüri Reimand et al. PLoS Genetics
- Understanding Pharmaceutical Quality by Design
- (2014) Lawrence X. Yu et al. AAPS Journal
- Direct Site-Specific Glycoform Identification and Quantitative Comparison of Glycoprotein Therapeutics: Imiglucerase and Velaglucerase Alfa
- (2014) Hongping Ye et al. AAPS Journal
- Post-translational structural modifications of immunoglobulin G and their effect on biological activity
- (2014) Laura K. Hmiel et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Modern analytics for naturally derived complex drug substances: NMR and MS tests for protamine sulfate from chum salmon
- (2014) Ashley C. Gucinski et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Higher order structure characterization of protein therapeutics by hydrogen/deuterium exchange mass spectrometry
- (2014) Richard Y.-C. Huang et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Generic Automated Method for Liquid Chromatography–Multiple Reaction Monitoring Mass Spectrometry Based Monoclonal Antibody Quantitation for Preclinical Pharmacokinetic Studies
- (2014) Qian Zhang et al. ANALYTICAL CHEMISTRY
- Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry
- (2014) Luca Fornelli et al. ANALYTICAL CHEMISTRY
- Middle-Down Mass Spectrometry Enables Characterization of Branched Ubiquitin Chains
- (2014) Ellen M. Valkevich et al. BIOCHEMISTRY
- Liquid formulation for antibody drugs
- (2014) Susumu Uchiyama BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Abstract 3214: Definition of biosimilars: Energy Resolved Oxonium Ion Monitoring (Erexim) technology grasps detailed N-glycan microheterogeneity on therapeutic antibodies.
- (2014) Koji Ueda et al. CANCER RESEARCH
- Size-exclusion chromatography-mass spectrometry with m-nitrobenzyl alcohol as post-column additive for direct characterization of size variants of monoclonal antibodies
- (2014) Chong-Feng Xu et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Development and Application of a Robust N ‐Glycan Profiling Method for Heightened Characterization of Monoclonal Antibodies and Related Glycoproteins
- (2014) Tanya Q. Shang et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- The therapeutic monoclonal antibody market
- (2014) Dawn M Ecker et al. mAbs
- The application of targeted mass spectrometry-based strategies to the detection and localization of post-translational modifications
- (2014) Navin Chicooree et al. MASS SPECTROMETRY REVIEWS
- The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics
- (2014) Francesco Lanucara et al. Nature Chemistry
- Ultra-high-performance liquid chromatography for the characterization of therapeutic proteins
- (2014) Szabolcs Fekete et al. TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- IgG Subclasses and Allotypes: From Structure to Effector Functions
- (2014) Gestur Vidarsson et al. Frontiers in Immunology
- Structural comparison of two anti-CD20 monoclonal antibody drug products using middle-down mass spectrometry
- (2013) Bo Wang et al. ANALYST
- Time Resolved Native Ion-Mobility Mass Spectrometry to Monitor Dynamics of IgG4 Fab Arm Exchange and “Bispecific” Monoclonal Antibody Formation
- (2013) François Debaene et al. ANALYTICAL CHEMISTRY
- Native Top-Down Electrospray Ionization-Mass Spectrometry of 158 kDa Protein Complex by High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
- (2013) Huilin Li et al. ANALYTICAL CHEMISTRY
- Automated, High-Throughput IgG-Antibody Glycoprofiling Platform
- (2013) Henning Stöckmann et al. ANALYTICAL CHEMISTRY
- Nanobodies: Natural Single-Domain Antibodies
- (2013) Serge Muyldermans Annual Review of Biochemistry
- Host cell protein analysis in therapeutic protein bioprocessing - methods and applications
- (2013) Anne Luise Tscheliessnig et al. Biotechnology Journal
- Principles of electron capture and transfer dissociation mass spectrometry applied to peptide and protein structure analysis
- (2013) Konstantin O. Zhurov et al. CHEMICAL SOCIETY REVIEWS
- Pharmacokinetics, Pharmacodynamics and Physiologically-Based Pharmacokinetic Modelling of Monoclonal Antibodies
- (2013) Miroslav Dostalek et al. CLINICAL PHARMACOKINETICS
- Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications
- (2013) Hui Wei et al. DRUG DISCOVERY TODAY
- Applications of capillary electrophoresis in characterizing recombinant protein therapeutics
- (2013) Shuai Sherry Zhao et al. ELECTROPHORESIS
- Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies
- (2013) Hao Zhang et al. FEBS LETTERS
- Post-translational Modifications and Mass Spectrometry Detection
- (2013) André M.N. Silva et al. FREE RADICAL BIOLOGY AND MEDICINE
- Bioanalytical LC–MS/MS of protein-based biopharmaceuticals
- (2013) Irene van den Broek et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry
- (2013) A. M. Sevy et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Site-specific antibody drug conjugates for cancer therapy
- (2013) Siler Panowski et al. mAbs
- Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion
- (2013) Elsa Wagner-Rousset et al. mAbs
- Antibody–drug conjugates
- (2013) Rachel S. Zolot et al. NATURE REVIEWS DRUG DISCOVERY
- Top-down structural analysis of posttranslationally modified proteins by Fourier transform ion cyclotron resonance-MS with hydrogen/deuterium exchange and electron capture dissociation
- (2013) Jingxi Pan et al. PROTEOMICS
- Development of a highly sensitive and specific enzyme-linked immunosorbent assay (ELISA) for the detection of phenylethanolamine A in tissue and feed samples and confirmed by liquid chromatography tandem mass spectrometry (LC–MS/MS)
- (2013) Biyun Cao et al. TALANTA
- Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy
- (2012) Narendra Chirmule et al. AAPS Journal
- Probing protein interactions with hydrogen/deuterium exchange and mass spectrometry—A review
- (2012) Andrew J. Percy et al. ANALYTICA CHIMICA ACTA
- Quantitative Structural Characterization of Local N-Glycan Microheterogeneity in Therapeutic Antibodies by Energy-Resolved Oxonium Ion Monitoring
- (2012) Atsuhiko Toyama et al. ANALYTICAL CHEMISTRY
- Characterization of Therapeutic Antibodies and Related Products
- (2012) Alain Beck et al. ANALYTICAL CHEMISTRY
- Evaluation of Intact Mass Spectrometry for the Quantitative Analysis of Protein Therapeutics
- (2012) Ashley C. Gucinski et al. ANALYTICAL CHEMISTRY
- Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry
- (2012) Alain Beck et al. ANALYTICAL CHEMISTRY
- Quantitative MALDI Tandem Mass Spectrometric Imaging of Cocaine from Brain Tissue with a Deuterated Internal Standard
- (2012) David A. Pirman et al. ANALYTICAL CHEMISTRY
- Native Intact Mass Determination of Antibodies Conjugated with Monomethyl Auristatin E and F at Interchain Cysteine Residues
- (2012) John F. Valliere-Douglass et al. ANALYTICAL CHEMISTRY
- Direct Approach for Qualitative and Quantitative Characterization of Glycoproteins Using Tandem Mass Tags and an LTQ Orbitrap XL Electron Transfer Dissociation Hybrid Mass Spectrometer
- (2012) Hongping Ye et al. ANALYTICAL CHEMISTRY
- Exploiting the glioblastoma peptidome to discover novel tumour-associated antigens for immunotherapy
- (2012) Valérie Dutoit et al. BRAIN
- Fc-fusion proteins: new developments and future perspectives
- (2012) Daniel M. Czajkowsky et al. EMBO Molecular Medicine
- Analysis of host-cell proteins in biotherapeutic proteins by comprehensive online two-dimensional liquid chromatography/mass spectrometry
- (2012) Catalin Doneanu et al. mAbs
- Dual targeting strategies with bispecific antibodies
- (2012) Roland Kontermann mAbs
- Differentiation of isomeric amino acid residues in proteins and peptides using mass spectrometry
- (2012) Pilar Perez Hurtado et al. MASS SPECTROMETRY REVIEWS
- Analysis of Intact Monoclonal Antibody IgG1 by Electron Transfer Dissociation Orbitrap FTMS
- (2012) Luca Fornelli et al. MOLECULAR & CELLULAR PROTEOMICS
- Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis
- (2012) Ludovic C. Gillet et al. MOLECULAR & CELLULAR PROTEOMICS
- Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars
- (2012) Steven A. Berkowitz et al. NATURE REVIEWS DRUG DISCOVERY
- Of [hamsters] and men
- (2012) Andres H. Gutiérrez et al. Human Vaccines & Immunotherapeutics
- Enhanced top-down characterization of histone post-translational modifications
- (2012) Zhixin Tian et al. GENOME BIOLOGY
- Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry
- (2011) Keyang Xu et al. ANALYTICAL BIOCHEMISTRY
- Native Electrospray and Electron-Capture Dissociation FTICR Mass Spectrometry for Top-Down Studies of Protein Assemblies
- (2011) Hao Zhang et al. ANALYTICAL CHEMISTRY
- Top-Down Sequencing of O-Glycoproteins by In-Source Decay Matrix-Assisted Laser Desorption Ionization Mass Spectrometry for Glycosylation Site Analysis
- (2011) Franz-Georg Hanisch ANALYTICAL CHEMISTRY
- Introduction to current and future protein therapeutics: A protein engineering perspective
- (2011) Paul J. Carter EXPERIMENTAL CELL RESEARCH
- Intact protein analysis in the biopharmaceutical field
- (2011) Aline Staub et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Improving SRM Assay Development: A Global Comparison between Triple Quadrupole, Ion Trap, and Higher Energy CID Peptide Fragmentation Spectra
- (2011) Erik L. de Graaf et al. JOURNAL OF PROTEOME RESEARCH
- Electron Capture, Collision-Induced, and Electron Capture-Collision Induced Dissociation in Q-TOF
- (2011) Valery G. Voinov et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Detection and Characterization of Low Abundance Glycopeptides Via Higher-Energy C-Trap Dissociation and Orbitrap Mass Analysis
- (2011) Gene Hart-Smith et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Electron Transfer Dissociation (ETD) of Peptides Containing Intrachain Disulfide Bonds
- (2011) Scott R. Cole et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Peptide and protein drugs: The study of their metabolism and catabolism by mass spectrometry
- (2011) Theodora Katsila et al. MASS SPECTROMETRY REVIEWS
- Acceptable changes in quality attributes of glycosylated biopharmaceuticals
- (2011) Martin Schiestl et al. NATURE BIOTECHNOLOGY
- Bioanalytical strategies for developing highly sensitive liquid chromatography/tandem mass spectrometry based methods for the peptide GLP-1 agonists in support of discovery PK/PD studies
- (2011) Hongwei Zhang et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Hydrogen exchange mass spectrometry for studying protein structure and dynamics
- (2010) Lars Konermann et al. CHEMICAL SOCIETY REVIEWS
- Mass spectrometry measurement of a therapeutic peptide for use in multiple sclerosis
- (2010) J M Dadgari et al. GENE THERAPY
- Performance of a sheathless porous tip sprayer for capillary electrophoresis–electrospray ionization-mass spectrometry of intact proteins
- (2010) Rob Haselberg et al. JOURNAL OF CHROMATOGRAPHY A
- Fine Mapping the Spatial Distribution and Concentration of Unlabeled Drugs within Tissue Micro-Compartments Using Imaging Mass Spectrometry
- (2010) Anna Nilsson et al. PLoS One
- What does the future hold for top down mass spectrometry?
- (2009) Benjamin A. Garcia JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Single domain antibodies: promising experimental and therapeutic tools in infection and immunity
- (2009) Janusz Wesolowski et al. MEDICAL MICROBIOLOGY AND IMMUNOLOGY
- High-throughput generation of selected reaction-monitoring assays for proteins and proteomes
- (2009) Paola Picotti et al. NATURE METHODS
- Electron Capture Dissociation of Electrosprayed Protein Ions for Spatially Resolved Hydrogen Exchange Measurements
- (2008) Jingxi Pan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Toward top-down determination of PEGylation site using MALDI in-source decay MS analysis
- (2008) Chul Yoo et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Application of electron transfer dissociation (ETD) for the analysis of posttranslational modifications
- (2008) Julia Wiesner et al. PROTEOMICS
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