Post-translational structural modifications of immunoglobulin G and their effect on biological activity
出版年份 2014 全文链接
标题
Post-translational structural modifications of immunoglobulin G and their effect on biological activity
作者
关键词
-
出版物
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 407, Issue 1, Pages 79-94
出版商
Springer Nature
发表日期
2014-09-09
DOI
10.1007/s00216-014-8108-x
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions
- (2014) Jasmin F. Sydow et al. PLoS One
- Structural comparison of two anti-CD20 monoclonal antibody drug products using middle-down mass spectrometry
- (2013) Bo Wang et al. ANALYST
- Top-down MS for rapid methionine oxidation site assignment in filgrastim
- (2013) Johann Holzmann et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Fermentanomics informed amino acid supplementation of an antibody producing mammalian cell culture
- (2013) Erik K. Read et al. BIOTECHNOLOGY PROGRESS
- Multispecificity of Immunoglobulin M Antibodies Raised against Advanced Glycation End Products
- (2013) Miho Chikazawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Monoclonal antibody heterogeneity analysis and deamidation monitoring with high-performance cation-exchange chromatofocusing using simple, two component buffer systems
- (2013) Xuezhen Kang et al. JOURNAL OF CHROMATOGRAPHY A
- Quality assurance of monoclonal antibody pharmaceuticals based on their charge variants using microchip isoelectric focusing method
- (2013) Mitsuhiro Kinoshita et al. JOURNAL OF CHROMATOGRAPHY A
- Accurate Identification of Deamidated Peptides in Global Proteomics Using a Quadrupole Orbitrap Mass Spectrometer
- (2013) Angelito I. Nepomuceno et al. JOURNAL OF PROTEOME RESEARCH
- Quantitative Glycomics Strategies
- (2013) Yehia Mechref et al. MOLECULAR & CELLULAR PROTEOMICS
- Galactose-α-1,3-Galactose–Specific IgE Is Associated with Anaphylaxis but Not Asthma
- (2012) Scott P. Commins et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Glycoprotein analysis using mass spectrometry: unraveling the layers of complexity
- (2012) John E. Schiel ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Characterization of Therapeutic Antibodies and Related Products
- (2012) Alain Beck et al. ANALYTICAL CHEMISTRY
- Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry
- (2012) Alain Beck et al. ANALYTICAL CHEMISTRY
- Quality attributes of recombinant therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach
- (2012) Alex Eon-Duval et al. BIOTECHNOLOGY PROGRESS
- Preferential recognition of epitopes on AGE–IgG by the autoantibodies in rheumatoid arthritis patients
- (2012) Saman Ahmad et al. HUMAN IMMUNOLOGY
- Physicochemical studies on glycation-induced structural changes in human IgG
- (2012) Saman Ahmad et al. IUBMB LIFE
- Significant Impact of SingleN-Glycan Residues on the Biological Activity of Fc-based Antibody-like Fragments
- (2012) Jakub Jez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Engineering an Improved IgG4 Molecule with Reduced Disulfide Bond Heterogeneity and Increased Fab Domain Thermal Stability
- (2012) Shirley J. Peters et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Robustness of iCIEF methodology for the analysis of monoclonal antibodies: An interlaboratory study
- (2012) Oscar Salas-Solano et al. JOURNAL OF SEPARATION SCIENCE
- Immunological studies on glycated human IgG
- (2012) Saman Ahmad et al. LIFE SCIENCES
- Immunotoxins constructed with chimeric, short-lived anti-CD22 monoclonal antibodies induce less vascular leak without loss of cytotoxicity
- (2012) Xiao-yun Liu et al. mAbs
- Disulfide bond structures of IgG molecules
- (2012) Hongcheng Liu et al. mAbs
- Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycans
- (2012) Marcella Yu et al. mAbs
- Characterization of Therapeutic Monoclonal Antibodies Reveals Differences Between In Vitro and In Vivo Time-Course Studies
- (2012) Sheng Yin et al. PHARMACEUTICAL RESEARCH
- Industry and regulatory experience of the glycosylation of monoclonal antibodies
- (2011) Erik K. Read et al. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
- Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform
- (2011) Efren Pacis et al. BIOTECHNOLOGY AND BIOENGINEERING
- Glycosylation profiles of therapeutic antibody pharmaceuticals
- (2011) Christoph Wacker et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans
- (2011) A. M. Goetze et al. GLYCOBIOLOGY
- Rates and impact of human antibody glycation in vivo
- (2011) A. M. Goetze et al. GLYCOBIOLOGY
- Impaired allergy diagnostics among parasite-infected patients caused by IgE antibodies to the carbohydrate epitope galactose-α1,3-galactose
- (2011) Kurt Arkestål et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- N-terminal Glutamate to Pyroglutamate Conversionin Vivofor Human IgG2 Antibodies
- (2011) Y. Diana Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography
- (2011) Taylor Zhang et al. JOURNAL OF CHROMATOGRAPHY A
- Mechanism of Immunoglobulin G4 Fab-arm Exchange
- (2011) Theo Rispens et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- High Throughput Isolation and Glycosylation Analysis of IgG–Variability and Heritability of the IgG Glycome in Three Isolated Human Populations
- (2011) Maja Pučić et al. MOLECULAR & CELLULAR PROTEOMICS
- Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies
- (2011) Weirong Wang et al. MOLECULAR IMMUNOLOGY
- Anti-galactose-α-1,3-galactose IgE from allergic patients does not bind α-galactosylated glycans on intact therapeutic antibody Fc domains
- (2011) Jeroen J Lammerts van Bueren et al. NATURE BIOTECHNOLOGY
- NMR analysis demonstrates immunoglobulin G N-glycans are accessible and dynamic
- (2011) Adam W Barb et al. Nature Chemical Biology
- Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose
- (2011) C. Ferrara et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterization of trisulfide modification in antibodies
- (2010) Sheng Gu et al. ANALYTICAL BIOCHEMISTRY
- Comparability assessments of process and product changes made during development of two different monoclonal antibodies
- (2010) Anthony Lubiniecki et al. BIOLOGICALS
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- (2010) Bing Cai et al. BIOTECHNOLOGY AND BIOENGINEERING
- Defining process design space for monoclonal antibody cell culture
- (2010) Susan Fugett Abu-Absi et al. BIOTECHNOLOGY AND BIOENGINEERING
- Glycation of monoclonal antibodies impairs their ability to bind antigen
- (2010) D. M. KENNEDY et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- A multi-method approach toward de novo glycan characterization: A Man-5 case study
- (2010) J. M. Prien et al. GLYCOBIOLOGY
- Assessing monoclonal antibody product quality attribute criticality through clinical studies
- (2010) Andrew M. Goetze et al. mAbs
- Differences in N-glycan structures found on recombinant IgA1 and IgA2 produced in murine myeloma and CHO cell lines
- (2010) Esther M. Yoo et al. mAbs
- Stability of IgG isotypes in serum
- (2010) Ivan Correia mAbs
- Charge variants in IgG1
- (2010) Leslie A. Khawli et al. mAbs
- Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding
- (2010) Damian Houde et al. MOLECULAR & CELLULAR PROTEOMICS
- Naturally occurring glycan forms of human immunoglobulins G1 and G2
- (2010) Gregory C. Flynn et al. MOLECULAR IMMUNOLOGY
- Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins
- (2010) Darius Ghaderi et al. NATURE BIOTECHNOLOGY
- Intrachain disulfide bond in the core hinge region of human IgG4
- (2010) James W. Bloom et al. PROTEIN SCIENCE
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- (2010) William Burkitt et al. PROTEIN SCIENCE
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- (2010) Heather Franey et al. PROTEIN SCIENCE
- Pharmacokinetic, pharmacodynamic and immunogenicity comparability assessment strategies for monoclonal antibodies
- (2010) Wendy S. Putnam et al. TRENDS IN BIOTECHNOLOGY
- Evidence for Trisulfide Bonds in a Recombinant Variant of a Human IgG2 Monoclonal Antibody
- (2009) Pavlo Pristatsky et al. ANALYTICAL CHEMISTRY
- Human antibody Fc deamidation in vivo
- (2009) Y. Diana Liu et al. BIOLOGICALS
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- (2009) Haitao Jiang et al. BIOTECHNOLOGY PROGRESS
- Optimal and consistent protein glycosylation in mammalian cell culture
- (2009) P. Hossler et al. GLYCOBIOLOGY
- Impact of methionine oxidation on the binding of human IgG1 to FcRn and Fcγ receptors
- (2009) Andrea Bertolotti-Ciarlet et al. MOLECULAR IMMUNOLOGY
- Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn
- (2009) Hai Pan et al. PROTEIN SCIENCE
- Immunological mechanism underlying the immune response to recombinant human protein therapeutics
- (2009) Melody Sauerborn et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Free sulfhydryl measurement as an indicator of antibody stability
- (2008) Eilyn R. Lacy et al. ANALYTICAL BIOCHEMISTRY
- Anti-Inflammatory Actions of Intravenous Immunoglobulin
- (2008) Falk Nimmerjahn et al. Annual Review of Immunology
- Structure and Stability Changes of Human IgG1 Fc as a Consequence of Methionine Oxidation
- (2008) Dingjiang Liu et al. BIOCHEMISTRY
- C-terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes
- (2008) Lawrence W. Dick et al. BIOTECHNOLOGY AND BIOENGINEERING
- Monoclonal Antibodies as Innovative Therapeutics
- (2008) Janice Reichert CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods
- (2008) J. Vlasak et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Glycation during storage and administration of monoclonal antibody formulations
- (2008) S FISCHER et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: Potential implications for disease
- (2008) V. Padler-Karavani et al. GLYCOBIOLOGY
- The effect of Fc glycan forms on human IgG2 antibody clearance in humans
- (2008) X. Chen et al. GLYCOBIOLOGY
- Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms
- (2008) Jette Wypych et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human IgG2 Antibody Disulfide Rearrangementin Vivo
- (2008) Y. Diana Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of methionine oxidation of a recombinant monoclonal antibody on the binding affinity to protein A and protein G
- (2008) Georgeen Gaza-Bulseco et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Advanced glycation end products induce in vitro cross‐linking of α‐synuclein and accelerate the process of intracellular inclusion body formation
- (2008) Shamim Shaikh et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Mass spectrometry analysis of photo-induced methionine oxidation of a recombinant human monoclonal antibody
- (2008) Hongcheng Liu et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Post-translational Modifications of Recombinant Proteins: Significance for Biopharmaceuticals
- (2008) Nigel Jenkins et al. MOLECULAR BIOTECHNOLOGY
- Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose
- (2008) Christine H. Chung et al. NEW ENGLAND JOURNAL OF MEDICINE
- Identification of a receptor required for the anti-inflammatory activity of IVIG
- (2008) R. M. Anthony et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc
- (2008) R. M. Anthony et al. SCIENCE
- A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior
- (2007) Cynthia Quan et al. ANALYTICAL BIOCHEMISTRY
- Structural effect of deglycosylation and methionine oxidation on a recombinant monoclonal antibody
- (2007) Hongcheng Liu et al. MOLECULAR IMMUNOLOGY
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