Pharmacokinetics, Pharmacodynamics and Physiologically-Based Pharmacokinetic Modelling of Monoclonal Antibodies
出版年份 2013 全文链接
标题
Pharmacokinetics, Pharmacodynamics and Physiologically-Based Pharmacokinetic Modelling of Monoclonal Antibodies
作者
关键词
-
出版物
CLINICAL PHARMACOKINETICS
Volume 52, Issue 2, Pages 83-124
出版商
Springer Nature
发表日期
2013-01-09
DOI
10.1007/s40262-012-0027-4
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Development of a Fully Human Anti-PDGFRβ Antibody That Suppresses Growth of Human Tumor Xenografts and Enhances Antitumor Activity of an Anti-VEGFR2 Antibody
- (2015) Juqun Shen et al. NEOPLASIA
- Activation of the JAK/STAT-1 Signaling Pathway by IFN- Can Down-Regulate Functional Expression of the MHC Class I-Related Neonatal Fc Receptor for IgG
- (2014) X. Liu et al. JOURNAL OF IMMUNOLOGY
- Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration
- (2012) Wolfgang F. Richter et al. AAPS Journal
- Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn
- (2012) Yang Chen et al. AAPS Journal
- Prediction of Clearance and Volume of Distribution in the Obese from Normal Weight Subjects
- (2012) Iftekhar Mahmood CLINICAL PHARMACOKINETICS
- De-Risking Bio-therapeutics for Possible Drug Interactions Using Cryopreserved Human Hepatocytes
- (2012) Shannon Dallas et al. CURRENT DRUG METABOLISM
- Effects of Interleukin 1β (IL-1β) and IL-1β/Interleukin 6 (IL-6) Combinations on Drug Metabolizing Enzymes in Human Hepatocyte Culture
- (2012) Leslie J. Dickmann et al. CURRENT DRUG METABOLISM
- Effects of Culture Duration on Gene Expression of P450 Isoforms, Uptake and Efflux Transporters in Primary Hepatocytes Cultured in the Absence and Presence of Interleukin- 6: Implications for Experimental Design for the Evaluation of Downregulatory Effects of Biotherapeutics
- (2012) Qian Yang et al. CURRENT DRUG METABOLISM
- Monoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development?
- (2012) Rong Deng et al. Expert Opinion on Drug Metabolism & Toxicology
- Dermal Clearance Model for Epidermal Bioavailability Calculations
- (2012) Rania Ibrahim et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Evaluation of Hepatic Clearance Prediction Using In Vitro Data: Emphasis on Fraction Unbound in Plasma and Drug Ionisation Using a Database of 107 Drugs
- (2012) David Hallifax et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification
- (2012) Lambertus A. Peletier et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Prediction of drug concentration-time data in humans from animals: a comparison of three methods
- (2012) Iftekhar Mahmood et al. XENOBIOTICA
- Omalizumab decreases IgE production in patients with allergic (IgE-mediated) asthma; PKPD analysis of a biomarker, total IgE
- (2011) Philip J. Lowe et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Model-based design of rituximab dosage optimization in follicular non-Hodgkin's lymphoma
- (2011) David Ternant et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Disease–Drug–Drug Interaction Involving Tocilizumab and Simvastatin in Patients With Rheumatoid Arthritis
- (2011) C Schmitt et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Trastuzumab emtansine in human epidermal growth factor receptor 2-positive breast cancer
- (2011) Jacob Mathew et al. CURRENT OPINION IN ONCOLOGY
- How Current Understanding of Clearance Mechanisms and Pharmacodynamics of Therapeutic Proteins Can Be Applied for Evaluation of Their Drug-Drug Interaction Potential
- (2011) E. Kraynov et al. DRUG METABOLISM AND DISPOSITION
- Effects of Interleukin-6 (IL-6) and an Anti-IL-6 Monoclonal Antibody on Drug-Metabolizing Enzymes in Human Hepatocyte Culture
- (2011) L. J. Dickmann et al. DRUG METABOLISM AND DISPOSITION
- Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences
- (2011) W. Wang et al. DRUG METABOLISM AND DISPOSITION
- Prediction of Human Plasma Concentration-time Profiles of Monoclonal Antibodies from Monkey Data by a Species-invariant Time Method
- (2011) Masataka Oitate et al. Drug Metabolism and Pharmacokinetics
- Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation
- (2011) Hadi Molanaei et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Pharmacokinetics and pharmacodynamics of basiliximab in Japanese pediatric renal transplant patients
- (2011) T. Nagai et al. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
- Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human
- (2011) Dhaval K. Shah et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Model-based determination of abatacept exposure in support of the recommended dose for Japanese rheumatoid arthritis patients
- (2011) Mayumi Hasegawa et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Mathematical analysis of the pharmacokinetic–pharmacodynamic (PKPD) behaviour of monoclonal antibodies: Predicting in vivo potency
- (2011) Philip J. Aston et al. JOURNAL OF THEORETICAL BIOLOGY
- Engineering the variable region of therapeutic IgG antibodies
- (2011) Tomoyuki Igawa et al. mAbs
- Subcutaneous Absorption of Monoclonal Antibodies: Role of Dose, Site of Injection, and Injection Volume on Rituximab Pharmacokinetics in Rats
- (2011) Leonid Kagan et al. PHARMACEUTICAL RESEARCH
- Pharmacokinetic-Pharmacodynamic Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-Induced Arthritis
- (2011) Hoi-Kei Lon et al. PHARMACEUTICAL RESEARCH
- Theoretical Considerations of Target-Mediated Drug Disposition Models: Simplifications and Approximations
- (2011) Peiming Ma PHARMACEUTICAL RESEARCH
- Targeted Drug Delivery by Gemtuzumab Ozogamicin: Mechanism-Based Mathematical Model for Treatment Strategy Improvement and Therapy Individualization
- (2011) Eva Jager et al. PLoS One
- Interspecies scaling and prediction of human clearance: comparison of small- and macro-molecule drugs
- (2011) Yeamin Huh et al. XENOBIOTICA
- A Randomized, Multicenter Study of Steroid Avoidance, Early Steroid Withdrawal or Standard Steroid Therapy in Kidney Transplant Recipients
- (2010) F. Vincenti et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics
- (2010) C. Andrew Boswell et al. BIOCONJUGATE CHEMISTRY
- Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies
- (2010) Diane R. Mould et al. BIODRUGS
- Population Pharmacokinetics of Therapeutic Monoclonal Antibodies
- (2010) Nathanael L. Dirks et al. CLINICAL PHARMACOKINETICS
- Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies
- (2010) Ron J. Keizer et al. CLINICAL PHARMACOKINETICS
- Translational Pharmacokinetics and Pharmacodynamics of an FcRn-Variant Anti-CD4 Monoclonal Antibody From Preclinical Model to Phase I Study
- (2010) Y Zheng et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Therapeutic Protein–Drug Interactions and Implications for Drug Development
- (2010) S-M Huang et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- IgE antibody-specific activity in human allergic disease
- (2010) Robert G. Hamilton et al. IMMUNOLOGIC RESEARCH
- Neonatal Fc Receptor: From Immunity to Therapeutics
- (2010) Timothy T. Kuo et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Population Pharmacokinetic Analysis of Tocilizumab in Patients With Rheumatoid Arthritis
- (2010) Nicolas Frey et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Integrated Population Pharmacokinetics of Etanercept in Healthy Subjects and in Patients With Rheumatoid Arthritis Ankylosing Spondylitis
- (2010) Simon Y. Zhou et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Target-mediated drug disposition model for drugs that bind to more than one target
- (2010) Leonid Gibiansky et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Modeling the efficacy of trastuzumab-DM1, an antibody drug conjugate, in mice
- (2010) Nelson L. Jumbe et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- The Application of Target Information and Preclinical Pharmacokinetic/Pharmacodynamic Modeling in Predicting Clinical Doses of a Dickkopf-1 Antibody for Osteoporosis
- (2010) A. M. Betts et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Charge variants in IgG1
- (2010) Leslie A. Khawli et al. mAbs
- Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization
- (2010) Tomoyuki Igawa et al. NATURE BIOTECHNOLOGY
- Chemical generation of bispecific antibodies
- (2010) V. R. Doppalapudi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reduced elimination of IgG antibodies by engineering the variable region
- (2010) T. Igawa et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Investigation of the Influence of FcRn on the Distribution of IgG to the Brain
- (2009) Amit Garg et al. AAPS Journal
- Biodistribution Mechanisms of Therapeutic Monoclonal Antibodies in Health and Disease
- (2009) Mohammad Tabrizi et al. AAPS Journal
- Photoactivation of Alkyl C−H and Silanization: A Simple and General Route to Prepare High-Density Primary Amines on Inert Polymer Surfaces for Protein Immobilization
- (2009) Shenghua Gan et al. BIOMACROMOLECULES
- Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
- (2009) Teemu T. Junttila et al. CANCER CELL
- Development of novel humanized anti-CD20 antibodies based on affinity constant and epitope
- (2009) Susumu Uchiyama et al. CANCER SCIENCE
- Functional and clinical consequences of Fc receptor polymorphic and copy number variants
- (2009) S. Bournazos et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor
- (2009) Zehra Kaymakcalan et al. CLINICAL IMMUNOLOGY
- Impact of Infectious and Inflammatory Disease on Cytochrome P450–Mediated Drug Metabolism and Pharmacokinetics
- (2009) ET Morgan CLINICAL PHARMACOLOGY & THERAPEUTICS
- Development of a PBPK Model for Monoclonal Antibodies and Simulation of Human and Mice PBPK of a Radiolabelled Monoclonal Antibody
- (2009) Tomi Heiskanen et al. CURRENT PHARMACEUTICAL DESIGN
- Risk-based strategy for the assessment of pharmacokinetic drug–drug interactions for therapeutic monoclonal antibodies
- (2009) Honghui Zhou et al. DRUG DISCOVERY TODAY
- Dual Mechanisms of CYP3A Protein Regulation by Proinflammatory Cytokine Stimulation in Primary Hepatocyte Cultures
- (2009) C.-M. Lee et al. DRUG METABOLISM AND DISPOSITION
- A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates
- (2009) Masoud Jamei et al. Drug Metabolism and Pharmacokinetics
- Population pharmacokinetic analysis of infliximab in patients with ulcerative colitis
- (2009) Adedigbo A. Fasanmade et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Dynamics of target-mediated drug disposition
- (2009) Lambertus A. Peletier et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Developing intrabodies for the therapeutic suppression of neurodegenerative pathology
- (2009) Anne Messer et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Fcγ receptors: structure, function and role as genetic risk factors in SLE
- (2009) X Li et al. GENES AND IMMUNITY
- Population Pharmacokinetic Analysis of Panitumumab in Patients With Advanced Solid Tumors
- (2009) Peiming Ma et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Population Pharmacokinetics of Golimumab, an Anti-Tumor Necrosis Factor-α Human Monoclonal Antibody, in Patients With Psoriatic Arthritis
- (2009) Zhenhua Xu et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Population Pharmacokinetic Modeling of Ustekinumab, a Human Monoclonal Antibody Targeting IL-12/23p40, in Patients With Moderate to Severe Plaque Psoriasis
- (2009) Yaowei Zhu et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Interspecies Scaling of Therapeutic Monoclonal Antibodies: Initial Look
- (2009) Jie Ling et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Pharmacokinetic Allometric Scaling of Antibodies: Application to the First-In-Human Dose Estimation
- (2009) Iftekhar Mahmood JOURNAL OF PHARMACEUTICAL SCIENCES
- Gaining insights into the consequences of target-mediated drug disposition of monoclonal antibodies using quasi-steady-state approximations
- (2009) Hans Peter Grimm JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Selection between Michaelis–Menten and target-mediated drug disposition pharmacokinetic models
- (2009) Xiaoyu Yan et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Predicting new molecular targets for known drugs
- (2009) Michael J. Keiser et al. NATURE
- Physiologically-Based PK/PD Modelling of Therapeutic Macromolecules
- (2009) Peter Thygesen et al. PHARMACEUTICAL RESEARCH
- Use of Quantitative Pharmacology in the Development of HAE1, a High-Affinity Anti-IgE Monoclonal Antibody
- (2008) Wendy S. Putnam et al. AAPS Journal
- Anti-Inflammatory Actions of Intravenous Immunoglobulin
- (2008) Falk Nimmerjahn et al. Annual Review of Immunology
- Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro
- (2008) M K Robinson et al. BRITISH JOURNAL OF CANCER
- Clinical pharmacokinetics of bevacizumab in patients with solid tumors
- (2008) Jian-Feng Lu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Monoclonal Antibody Pharmacokinetics and Pharmacodynamics
- (2008) W Wang et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Molecular engineering and design of therapeutic antibodies
- (2008) Leonard G Presta CURRENT OPINION IN IMMUNOLOGY
- Predictive Physiologically Based Pharmacokinetic Model for Antibody-Directed Enzyme Prodrug Therapy
- (2008) L. Fang et al. DRUG METABOLISM AND DISPOSITION
- Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor- or Interleukin-6
- (2008) M. L. Vee et al. DRUG METABOLISM AND DISPOSITION
- Regulation of Drug-Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer
- (2008) E. T. Morgan et al. DRUG METABOLISM AND DISPOSITION
- Whole body physiologically-based pharmacokinetic models: their use in clinical drug development
- (2008) Andrea N Edginton et al. Expert Opinion on Drug Metabolism & Toxicology
- Population Pharmacokinetics of Cetuximab in Patients With Squamous Cell Carcinoma of the Head and Neck
- (2008) Nathanae L. Dirks et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Population Pharmacokinetics of Infliximab in Patients With Ankylosing Spondylitis
- (2008) Zhenhua Xu et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Approximations of the target-mediated drug disposition model and identifiability of model parameters
- (2008) Leonid Gibiansky et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Integrated Cellular Bone Homeostasis Model for Denosumab Pharmacodynamics in Multiple Myeloma Patients
- (2008) A. Marathe et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Prognostic significance of maximum tumour (bulk) diameter in young patients with good-prognosis diffuse large-B-cell lymphoma treated with CHOP-like chemotherapy with or without rituximab: an exploratory analysis of the MabThera International Trial Group (MInT) study
- (2008) Michael Pfreundschuh et al. LANCET ONCOLOGY
- The Role of Complement in the Mechanism of Action of Rituximab for B-Cell Lymphoma: Implications for Therapy
- (2008) X. Zhou et al. ONCOLOGIST
- Pharmacokinetics and Immunodynamics of Basiliximab in Pediatric Renal Transplant Recipients on Mycophenolate Mofetil Comedication
- (2008) Britta Höcker et al. TRANSPLANTATION
- A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructs
- (2007) Jasmine P. Davda et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- On the Volume of Distribution at Steady State and Its Relationship With Two‐Compartmental Models
- (2007) James W.T. Yates et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Tumor necrosis factor antagonist mechanisms of action: A comprehensive review
- (2007) Daniel Tracey et al. PHARMACOLOGY & THERAPEUTICS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now