Danger signals from mitochondrial DAMPS in trauma and post-injury sepsis

Mitochondrial transfer between cells: Methodological constraints in cell culture and animal models

(2018) M.V. Berridge et al.   ANALYTICAL BIOCHEMISTRY

Intercellular mitochondria trafficking highlighting the dual role of mesenchymal stem cells as both sensors and rescuers of tissue injury

(2018) Anne-Marie Rodriguez et al.   CELL CYCLE

Modulation of innate and adaptive immunity by P2X ion channels

(2018) Francesco Di Virgilio et al.   CURRENT OPINION IN IMMUNOLOGY

Mechanisms of ATP Release by Inflammatory Cells

(2018) Michel Dosch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A SUBSET OF FIVE HUMAN MITOCHONDRIAL FORMYL PEPTIDES MIMICS BACTERIAL PEPTIDES AND FUNCTIONALLY DEACTIVATES HUMAN NEUETROPHILS

(2018) Elzbieta Kaczmarek et al.   Journal of Trauma and Acute Care Surgery

Mitochondrial Toxicity

(2018) Joel N Meyer et al.   TOXICOLOGICAL SCIENCES

Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells

(2018) Bartosz Szczesny et al.   Scientific Reports

A SUBSET OF FIVE HUMAN MITOCHONDRIAL FORMYL PEPTIDES MIMICS BACTERIAL PEPTIDES AND FUNCTIONALLY DEACTIVATES HUMAN NEUETROPHILS

(2018) Elzbieta Kaczmarek et al.   Journal of Trauma and Acute Care Surgery

Degraded Mitochondrial DNA is a Newly Identified Subtype of the Damage Associated Molecular Pattern (DAMP) Family and Possible Trigger of Neurodegeneration

(2018) Alex Mathew et al.   JOURNAL OF ALZHEIMERS DISEASE

Characterization of plasma labile heme in hemolytic conditions

(2017) Zélia Gouveia et al.   FEBS Journal

Intratracheal instillation of neutrophils rescues bacterial overgrowth initiated by trauma damage-associated molecular patterns

(2017) Kiyoshi Itagaki et al.   Journal of Trauma and Acute Care Surgery

Purinergic signalling links mechanical breath profile and alveolar mechanics with the pro-inflammatory innate immune response causing ventilation-induced lung injury

(2017) Djo Hasan et al.   Purinergic Signalling

The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

(2017) Krishnendu Chakraborty et al.   Nature Communications

Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise

(2017) Adeel Safdar et al.   Cold Spring Harbor Perspectives in Medicine

Intratracheal instillation of neutrophils rescues bacterial overgrowth initiated by trauma damage-associated molecular patterns

(2017) Kiyoshi Itagaki et al.   Journal of Trauma and Acute Care Surgery

The P2X7 Receptor-Interleukin-1 Liaison

(2017) Anna Lisa Giuliani et al.   Frontiers in Pharmacology

Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration

(2017) Heather M. Wilkins et al.   Frontiers in Immunology

Heme Oxygenase-1 and Carbon Monoxide in the Heart

(2016) Leo E. Otterbein et al.   CIRCULATION RESEARCH

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Characterization of intercellular communication and mitochondrial donation by mesenchymal stromal cells derived from the human lung

(2016) Kenneth Andrew Sinclair et al.   Stem Cell Research & Therapy

Mitochondrial DNA in the regulation of innate immune responses

(2015) Chunju Fang et al.   Protein & Cell

Ventilator-associated pneumonia rates at major trauma centers compared with a national benchmark

(2015) Christopher P. Michetti et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mitochondrial damage-associated molecular patterns released by abdominal trauma suppress pulmonary immune responses

(2014) Cong Zhao et al.   Journal of Trauma and Acute Care Surgery

Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia

(2014) Jonathan P. Little et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

(2014) Kiichi Nakahira et al.   PLOS MEDICINE

MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice

(2013) J. D. Belcher et al.   BLOOD

NADPH Oxidase and Nrf2 Regulate Gastric Aspiration-Induced Inflammation and Acute Lung Injury

(2013) B. A. Davidson et al.   JOURNAL OF IMMUNOLOGY

National Trauma Institute prospective evaluation of the ventilator bundle in trauma patients

(2013) Martin A. Croce et al.   Journal of Trauma and Acute Care Surgery

Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways

(2013) Shiqin Sun et al.   PLoS One

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Activation of P2X7 Receptor by ATP Plays an Important Role in Regulating Inflammatory Responses during Acute Viral Infection

(2012) Benjamin H. Lee et al.   PLoS One

Go Green: The Anti-Inflammatory Effects of Biliverdin Reductase

(2012) Barbara Wegiel et al.   Frontiers in Pharmacology

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

The therapeutic potential of carbon monoxide

(2010) Roberto Motterlini et al.   NATURE REVIEWS DRUG DISCOVERY

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

(2010) Qin Zhang et al.   SHOCK

Mitochondrial Peptides Are Potent Immune Activators That Activate Human Neutrophils Via FPR-1

(2010) Mustafa Raoof et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Hemoglobin and Heme Scavenger Receptors

(2009) Marianne Jensby Nielsen et al.   ANTIOXIDANTS & REDOX SIGNALING

Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors

(2009) Elliott D. Crouser et al.   CRITICAL CARE MEDICINE

A central role for free heme in the pathogenesis of severe malaria: the missing link?

(2008) Ana Ferreira et al.   JOURNAL OF MOLECULAR MEDICINE-JMM