The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

Inflammation's stop signals

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Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity

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Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity

(2015) Krishnakumar Balasubramanian et al.   Science Signaling

Inflammasome activation has an important role in the development of spontaneous colitis

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A mitochondrial pathway for biosynthesis of lipid mediators

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Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction

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Regulation and Repair of the Alveolar-Capillary Barrier in Acute Lung Injury

(2013) Jahar Bhattacharya et al.   Annual Review of Physiology

Resolution of Acute Inflammation in the Lung

(2013) Bruce D. Levy et al.   Annual Review of Physiology

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

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PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Sodium Butyrate Protects against Severe Burn-Induced Remote Acute Lung Injury in Rats

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The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

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Immunosuppressive MDSCs induced by TLR signaling during infection and role in resolution of inflammation

(2013) Anuradha Ray et al.   Frontiers in Cellular and Infection Microbiology

STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia

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PPARs: Fatty acid sensors controlling metabolism

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PPARs at the crossroads of lipid signaling and inflammation

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The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation

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The complexity of cardiolipin in health and disease

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Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

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Nonresolving Inflammation

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Microbial Etiologies of Hospital‐Acquired Bacterial Pneumonia and Ventilator‐Associated Bacterial Pneumonia

(2010) Ronald N. Jones   CLINICAL INFECTIOUS DISEASES

Activation of the interleukin-10 gene in the human T lymphoma line HuT 78: identification and characterization of NF-κ B binding sites in the regulatory region of the interleukin-10 gene

(2010) Naoki Mori et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Phospholipase D2-Dependent Inhibition of the Nuclear Hormone Receptor PPARγ by Cyclic Phosphatidic Acid

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TLR4/MyD88-induced CD11b+Gr-1intF4/80+ non-migratory myeloid cells suppress Th2 effector function in the lung

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Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia

(2010) Nancy B Ray et al.   NATURE MEDICINE

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

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Mechanisms of Neutrophil Accumulation in the Lungs Against Bacteria

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Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose

(2009) Margarida Saraiva et al.   IMMUNITY

c-Maf Regulates IL-10 Expression during Th17 Polarization

(2009) Jiangnan Xu et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

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Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

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Posttranslational Modifications of PPAR-γ: Fine-tuning the Metabolic Master Regulator

(2009) Olivier van Beekum et al.   Obesity

A calculated response: control of inflammation by the innate immune system

(2008) Gregory M. Barton   JOURNAL OF CLINICAL INVESTIGATION

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

(2008) Olga Ananieva et al.   NATURE IMMUNOLOGY

Acute Lower Respiratory Tract Infection

(2008) Joseph P. Mizgerd   NEW ENGLAND JOURNAL OF MEDICINE

Enterococcus faecalis from newborn babies regulate endogenous PPAR  activity and IL-10 levels in colonic epithelial cells

(2008) A. Are et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA