Biological chemistry and functionality of protein sulfenic acids and related thiol modifications

DUBs, the regulation of cell identity and disease

(2015) Johanna Heideker et al.   BIOCHEMICAL JOURNAL

Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1

(2015) Brendan T. Innes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reactivity of Persulfides Toward Strained Bicyclo[6.1.0]nonyne Derivatives: Relevance to Chemical Tagging of Proteins

(2015) Erwan Galardon et al.   BIOCONJUGATE CHEMISTRY

Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub?

(2015) Thomas Hildebrandt et al.   BIOLOGICAL CHEMISTRY

Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons

(2015) Emmanuel Y. Dotsey et al.   CHEMISTRY & BIOLOGY

Synthesis, Structure, and Reactivities of a Stable Primary-alkyl-substituted Sulfenic Acid

(2015) Michihiro Ishihara et al.   CHEMISTRY LETTERS

ROS-Mediated DNA Methylation Pattern Alterations in Carcinogenesis

(2015) Qihan Wu et al.   CURRENT DRUG TARGETS

Mass spectrometry in studies of protein thiol chemistry and signaling: Opportunities and caveats

(2015) Nelmi O. Devarie Baez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox Control of Protein Arginine Methyltransferase 1 (PRMT1) Activity

(2015) Yalemi Morales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Streptozotocin Stimulates the Ion Channel TRPA1 Directly

(2015) David A. Andersson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SNO/SOH TMT strategy for combinatorial analysis of reversible cysteine oxidations

(2015) Katarzyna Wojdyla et al.   Journal of Proteomics

Arginine methyltransferases as novel therapeutic targets for breast cancer

(2015) A. Morettin et al.   MUTAGENESIS

A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation

(2015) David Peralta et al.   Nature Chemical Biology

Global, in situ, site-specific analysis of protein S-sulfenylation

(2015) Jing Yang et al.   Nature Protocols

Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease

(2015) Chun-Hau Chen et al.   NEUROBIOLOGY OF DISEASE

Cysteine-mediated redox regulation of cell signaling in chondrocytes stimulated with fibronectin fragments

(2015) S.T. Wood et al.   OSTEOARTHRITIS AND CARTILAGE

Protein Topology Determines Cysteine Oxidation Fate: The Case of Sulfenyl Amide Formation among Protein Families

(2015) Lucas A. Defelipe et al.   PLoS Computational Biology

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

(2015) Mirjam Eberhardt et al.   Nature Communications

Proteomic Profiling of Nitrosative Stress: Protein S-Oxidation Accompanies S-Nitrosylation

(2014) Yue-Ting Wang et al.   ACS Chemical Biology

Broad Phenotypic Changes Associated with Gain of Radiation Resistance in Head and Neck Squamous Cell Cancer

(2014) Nidhi Bansal et al.   ANTIOXIDANTS & REDOX SIGNALING

Signalling specificity in the Akt pathway in breast cancer

(2014) Abbe R. Clark et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Reactivity of C-Terminal Cysteines with HNO

(2014) Gizem Keceli et al.   BIOCHEMISTRY

The Basic Biology of Redoxosomes in Cytokine-Mediated Signal Transduction and Implications for Disease-Specific Therapies

(2014) Netanya Y. Spencer et al.   BIOCHEMISTRY

Superoxide Dismutases and Superoxide Reductases

(2014) Yuewei Sheng et al.   CHEMICAL REVIEWS

Synthesis and Identification of Solution-Stable Sulfenic Acids: Perfluoroalkanesulfenic Acids

(2014) Xiao-Bo Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling

(2014) Chananat Klomsiri et al.   FREE RADICAL BIOLOGY AND MEDICINE

The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor κB family proteins

(2014) James D. Nolin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ionizing radiation-induced oxidative stress, epigenetic changes and genomic instability: The pivotal role of mitochondria

(2014) Irena Szumiel   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Strained Cycloalkynes as New Protein Sulfenic Acid Traps

(2014) Thomas H. Poole et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling

(2014) Mirko C Sobotta et al.   Nature Chemical Biology

Mechanism of oxidant-induced mistranslation by threonyl-tRNA synthetase

(2014) Jiang Wu et al.   NUCLEIC ACIDS RESEARCH

S-Glutathionylation of an Auxiliary Subunit Confers Redox Sensitivity to Kv4 Channel Inactivation

(2014) Henry H. Jerng et al.   PLoS One

The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

(2014) M. A. Lemmon et al.   Cold Spring Harbor Perspectives in Biology

Active DNA demethylation of the vertebrate genomes by DNA methyltransferases: deaminase, dehydroxymethylase or demethylase?

(2014) Keh-Yang Wang et al.   Epigenomics

Site-specific mapping and quantification of protein S-sulphenylation in cells

(2014) Jing Yang et al.   Nature Communications

Structural diversity of neuronal calcium sensor proteins and insights for activation of retinal guanylyl cyclase by GCAP1

(2014) Sunghyuk Lim et al.   Frontiers in Molecular Neuroscience

Redox Regulation of Transient Receptor Potential Channels

(2013) Daisuke Kozai et al.   ANTIOXIDANTS & REDOX SIGNALING

Human Apurinic/Apyrimidinic Endonuclease 1

(2013) Mengxia Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids

(2013) Julie A. Reisz et al.   FEBS Journal

A Highly Conserved Cysteine of Neuronal Calcium-sensing Proteins Controls Cooperative Binding of Ca2+to Recoverin

(2013) Matthew J. Ranaghan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for the Resistance of Human Mitochondrial 2-Cys Peroxiredoxin 3 to Hyperoxidation

(2013) Alexina C. Haynes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformers of Cysteine and Cysteine Sulfenic Acid and Mechanisms of the Reaction of Cysteine Sulfenic Acid with 5,5-Dimethyl-1,3-cyclohexanedione (Dimedone)

(2013) Fillmore Freeman et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Capturing a Sulfenic Acid with Arylboronic Acids and Benzoxaborole

(2013) C. Tony Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nitrite Reduction Mediated by Heme Models. Routes to NO and HNO?

(2013) Julie L. Heinecke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells

(2013) Sudjit Luanpitpong et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of the catalytic domain of protein tyrosine phosphatase sigma in the sulfenic acid form

(2013) Tae Jin Jeon et al.   MOLECULES AND CELLS

Resin-assisted enrichment of thiols as a general strategy for proteomic profiling of cysteine-based reversible modifications

(2013) Jia Guo et al.   Nature Protocols

Disulfide Scrambling in Superoxide Dismutase 1 Reduces Its Cytotoxic Effect in Cultured Cells and Promotes Protein Aggregation

(2013) Lina Leinartaitė et al.   PLoS One

Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance

(2013) P. A. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of A20 and other OTU deubiquitinases by reversible oxidation

(2013) Yogesh Kulathu et al.   Nature Communications

Role of G protein-coupled receptors in inflammation

(2012) Lei Sun et al.   ACTA PHARMACOLOGICA SINICA

A role for His-160 in peroxide inhibition of S. cerevisiae S-formylglutathione hydrolase: Evidence for an oxidation sensitive motif

(2012) Patricia M. Legler et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation

(2012) Thu H. Truong et al.   BIOCHEMISTRY

Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical

(2012) Fan-Guo Meng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes

(2012) Jiang Qian et al.   CHEMICAL COMMUNICATIONS

Redox-Sensitive Sulfenic Acid Modification Regulates Surface Expression of the Cardiovascular Voltage-Gated Potassium Channel Kv1.5

(2012) Laurie K. Svoboda et al.   CIRCULATION RESEARCH

The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation

(2012) Katie E. Crump et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Protein arginine methyltransferases (PRMTs) as therapeutic targets

(2012) Boksik Cha et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Identification of a redox-sensitive switch within the JAK2 catalytic domain

(2012) John K. Smith et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates

(2012) Tessa J. Barrett et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox regulation of the epigenetic landscape in Cancer: A role for metabolic reprogramming in remodeling the epigenome

(2012) Michael J. Hitchler et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reversible inactivation of dihydrolipoamide dehydrogenase by mitochondrial hydrogen peroxide

(2012) Liang-Jun Yan et al.   FREE RADICAL RESEARCH

The Mammaliande NovoDNA Methyltransferases DNMT3A and DNMT3B Are Also DNA 5-Hydroxymethylcytosine Dehydroxymethylases

(2012) Chun-Chang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress InducedS-glutathionylation and Proteolytic Degradation of Mitochondrial Thymidine Kinase 2

(2012) Ren Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Glutathionylation underscores the modulation of the heteromeric Kir4.1-Kir5.1 channel in oxidative stress

(2012) Xin Jin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxidized DJ-1 Inhibits p53 by Sequestering p53 from Promoters in a DNA-Binding Affinity-Dependent Manner

(2012) I. Kato et al.   MOLECULAR AND CELLULAR BIOLOGY

Deubiquitinases as a Signaling Target of Oxidative Stress

(2012) Xiomaris M. Cotto-Rios et al.   Cell Reports

Oxidation mimicking substitution of conservative cysteine in recoverin suppresses its membrane association

(2011) Sergei E. Permyakov et al.   AMINO ACIDS

Quantification of Protein Sulfenic Acid Modifications Using Isotope-Coded Dimedone and Iododimedone

(2011) Young Ho Seo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein Glutathionylation in the Regulation of Peroxiredoxins: A Family of Thiol-Specific Peroxidases That Function As Antioxidants, Molecular Chaperones, and Signal Modulators

(2011) Ho Zoon Chae et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathionylation at Cys-111 Induces Dissociation of Wild Type and FALS Mutant SOD1 Dimers

(2011) Rachel L. Redler et al.   BIOCHEMISTRY

Characterization of the Redox Activity and Disulfide Bond Formation in Apurinic/Apyrimidinic Endonuclease

(2011) Meihua Luo et al.   BIOCHEMISTRY

Isotope-coded chemical reporter and acid-cleavable affinity reagents for monitoring protein sulfenic acids

(2011) Thu H. Truong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Akt kinases: Isoform specificity in metabolism and cancer

(2011) Eva Gonzalez et al.   CELL CYCLE

Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins

(2011) Jiang Qian et al.   CHEMICAL COMMUNICATIONS

Factors Affecting Protein Thiol Reactivity and Specificity in Peroxide Reduction

(2011) Gerardo Ferrer-Sueta et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Localized cysteine sulfenic acid formation by vascular endothelial growth factor: role in endothelial cell migration and angiogenesis

(2011) Nihal Kaplan et al.   FREE RADICAL RESEARCH

Regulation of protein tyrosine phosphatases by reversible oxidation

(2011) Arne Östman et al.   JOURNAL OF BIOCHEMISTRY

Molecular Basis and Structural Insight of Vascular KATPChannel Gating byS-Glutathionylation

(2011) Yang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Glutathionylation of Cysteine 99 in the APE1 Protein Impairs Abasic Endonuclease Activity

(2011) Yun-Jeong Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity

(2011) Candice E Paulsen et al.   Nature Chemical Biology

Cell Cycle Proteins in Brain in Mild Cognitive Impairment: Insights into Progression to Alzheimer Disease

(2011) Jeriel T. R. Keeney et al.   NEUROTOXICITY RESEARCH

Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species

(2011) R. Wani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

APE1/Ref-1Role in Redox Signaling: Translational Applications of Targeting the Redox Function of the DNA Repair/Redox Protein APE1/Ref-1

(2011) Mark R. Kelley et al.   Current Molecular Pharmacology

Glyceraldehyde 3-Phosphate Dehydrogenase is Unlikely to Mediate Hydrogen Peroxide Signaling: Studies with a Novel Anti-Dimedone Sulfenic Acid Antibody

(2010) Claire Maller et al.   ANTIOXIDANTS & REDOX SIGNALING

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

(2010) Hyun Ae Woo et al.   CELL

A positive role for c-Abl in Atm and Atr activation in DNA damage response

(2010) X Wang et al.   CELL DEATH AND DIFFERENTIATION

Postischemic Deactivation of Cardiac Aldose Reductase

(2010) Karin Wetzelberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of Cysteine Sulfenic Acid by Oxygen Atom Transfer from Nitrite

(2010) Julie Heinecke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Severe oxidative stress induces protein mistranslation through impairment of an aminoacyl-tRNA synthetase editing site

(2010) J. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Regulation of SH2-Domain-Containing Protein Tyrosine Phosphatases by Two Backdoor Cysteines

(2009) Cheng-Yu Chen et al.   BIOCHEMISTRY

A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors

(2009) AR King et al.   BRITISH JOURNAL OF PHARMACOLOGY

Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling

(2009) Geoffray Labar et al.   CHEMBIOCHEM

Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors

(2009) Alvin R. King et al.   CHEMISTRY & BIOLOGY

Vascular signaling through G protein-coupled receptors: new concepts

(2009) Masuko Ushio-Fukai   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Typical 2-Cys peroxiredoxins - structures, mechanisms and functions

(2009) Andrea Hall et al.   FEBS Journal

The roles of IL-17A in inflammatory immune responses and host defense against pathogens

(2009) Yoichiro Iwakura et al.   IMMUNOLOGICAL REVIEWS

Modifications of Superoxide Dismutase (SOD1) in Human Erythrocytes

(2009) Kyle C. Wilcox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidation

(2009) D. J. Kemble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling

(2009) E. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling protein thiol oxidation in tumor cells using sulfenic acid-specific antibodies

(2009) Y. H. Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Components of Redox Active Endosomes: The Redoxosomes

(2008) Fredrick D. Oakley et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox regulation of methylthioadenosine phosphorylase in liver cells: molecular mechanism and functional implications

(2008) Joaquín Fernández-Irigoyen et al.   BIOCHEMICAL JOURNAL

Inhibition of caspase-3 activity and activation by protein glutathionylation

(2008) Zhishan Huang et al.   BIOCHEMICAL PHARMACOLOGY

Structural Characterization and Reversal of the Natural Organophosphate Resistance of a D-Type Esterase,Saccharomyces cerevisiaeS-Formylglutathione Hydrolase†‡

(2008) Patricia M. Legler et al.   BIOCHEMISTRY

Regulation of cathepsin K activity by hydrogen peroxide

(2008) Emmanuel Godat et al.   BIOLOGICAL CHEMISTRY

Biologically relevant chemical properties of peroxymonophosphate (O3POOH)

(2008) Jason N. LaButti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-function relationships in methionine adenosyltransferases

(2008) G. D. Markham et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Role of Reactive Oxygen Species in Integrin and Matrix Metalloproteinase Expression and Function

(2008) Gunbjørg Svineng et al.   CONNECTIVE TISSUE RESEARCH

Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase

(2008) Tomoko Nishino et al.   FEBS Journal

Epigenetic Changes Induced by Reactive Oxygen Species in Hepatocellular Carcinoma: Methylation of the E-cadherin Promoter

(2008) Seung-Oe Lim et al.   GASTROENTEROLOGY

Role of Cys-1327 and Cys-1337 in Redox Sensitivity and Allosteric Monitoring in Human Carbamoyl Phosphate Synthetase

(2008) Emily J. Hart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Nitric Oxide in Regulating Aldose Reductase Activation in the Ischemic Heart

(2008) Karin Kaiserova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Intact Protein Thiosulfinate Intermediate in the Reduction of Cysteine Sulfinic Acid in Peroxiredoxin by Human Sulfiredoxin

(2008) Thomas J. Jönsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation

(2007) Zheng Xu et al.   FASEB JOURNAL