Is irisin the new player in exercise-induced adaptations or not? A 2017 update

5 years later: irisin detection still an issue

(2017) Alexandra B Cooke et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Combined training, FNDC5/irisin levels and metabolic markers in obese men: A randomised controlled trial

(2017) Ivan Luiz Padilha Bonfante et al.   European Journal of Sport Science

Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation

(2017) Agnieszka Irena Mazur-Bialy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Irisin acts as a regulator of macrophages host defense

(2017) Agnieszka Irena Mazur-Bialy   LIFE SCIENCES

The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia

(2017) Dong-Jie Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Physiology and role of irisin in glucose homeostasis

(2017) Nikolaos Perakakis et al.   Nature Reviews Endocrinology

Benefits of High-Intensity Exercise Training to Patients with Chronic Obstructive Pulmonary Disease: A Controlled Study

(2017) Tobias Boeselt et al.   RESPIRATION

Beneficial Effect of Voluntary Exercise on Experimental Colitis in Mice Fed a High-Fat Diet: The Role of Irisin, Adiponectin and Proinflammatory Biomarkers

(2017) Agnieszka Mazur-Bialy et al.   Nutrients

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

(2017) Graziana Colaianni et al.   Scientific Reports

Crosstalk between adipokines and myokines in fat browning

(2016) A. Rodríguez et al.   Acta Physiologica

Irisin exerts dual effects on browning and adipogenesis of human white adipocytes

(2016) Yuan Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of partial vascular occlusion on irisin responses to loaded muscle contractions

(2016) Robert R. Kraemer et al.   Applied Physiology Nutrition and Metabolism

Influence of endurance and sprinting exercise on plasma adiponectin, leptin and irisin concentrations in racing Greyhounds and sled dogs

(2016) MA Bell et al.   AUSTRALIAN VETERINARY JOURNAL

Regular physical activity and cardiovascular biomarkers in prevention of atherosclerosis in men: a 25-year prospective cohort study

(2016) Magdalena Kwaśniewska et al.   BMC Cardiovascular Disorders

Central inhibitory effects on feeding induced by the adipo-myokine irisin

(2016) Claudio Ferrante et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Irisin Increased the Number and Improved the Function of Endothelial Progenitor Cells in Diabetes Mellitus Mice

(2016) Guangxu Zhu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Browning of subcutaneous fat and higher surface temperature in response to phenotype selection for advanced endurance exercise performance in male DUhTP mice

(2016) J. Brenmoehl et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Effects of exercise on Irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis

(2016) Sven Briken et al.   JOURNAL OF NEUROIMMUNOLOGY

Voluntary stand-up physical activity enhances endurance exercise capacity in rats

(2016) Dae Yun Seo et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Effects of physical exercise on myokines expression and brown adipose-like phenotype modulation in rats fed a high-fat diet

(2016) Sílvia Rocha-Rodrigues et al.   LIFE SCIENCES

Swimming exercise increases serum irisin level and reduces body fat mass in high-fat-diet fed Wistar rats

(2016) Yun Lu et al.   Lipids in Health and Disease

Effect of sprint training on resting serum irisin concentration — Sprint training once daily vs. twice every other day

(2016) Yoshifumi Tsuchiya et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways

(2016) Xiaoyong Qiao et al.   Scientific Reports

Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects

(2016) Yaeko Fukushima et al.   Diabetes & Metabolism Journal

FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity

(2015) Xiao-Qing Xiong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

(2015) Mark P. Jedrychowski et al.   Cell Metabolism

Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity

(2015) Andrea Palermo et al.   CLINICAL ENDOCRINOLOGY

Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2

(2015) Nasser M. Al-Daghri et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans

(2015) Hee-jae Kim et al.   EXPERIMENTAL GERONTOLOGY

Acute effects of different degrees of ultra-endurance exercise on systemic inflammatory responses

(2015) M. Comassi et al.   INTERNAL MEDICINE JOURNAL

Low brown adipose tissue activity in endurance-trained compared with lean sedentary men

(2015) M J Vosselman et al.   INTERNATIONAL JOURNAL OF OBESITY

SMAD3 Negatively Regulates Serum Irisin and Skeletal Muscle FNDC5 and Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) during Exercise

(2015) Joseph P. Tiano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Irisin in Response to Exercise in Humans With and Without Metabolic Syndrome

(2015) Joo Young Huh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Serum Irisin Levels Are Regulated by Acute Strenuous Exercise

(2015) Dennis Löffler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Circulating Irisin Concentrations in Rat Models of Thyroid Dysfunction — Effect of Exercise

(2015) Doaa M. Samy et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Resistance exercise induces a greater irisin response than endurance exercise

(2015) Yoshifumi Tsuchiya et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice

(2015) Tamiris Lima Rachid et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Irisin levels before and after physical activity among school-age children with different BMI: A direct relation with leptin

(2015) Berenice Palacios-González et al.   Obesity

Irisin, a newly discovered myokine, is a novel biomarker associated with physical activity in patients with chronic obstructive pulmonary disease

(2015) Naoki Ijiri et al.   RESPIROLOGY

Chronic Exercise Training and Circulating Irisin in Adults: A Meta-Analysis

(2015) Shanhu Qiu et al.   SPORTS MEDICINE

Circulating irisin detection: Does it really work?

(2015) Fabian Sanchis-Gomar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Irisin – a myth rather than an exercise-inducible myokine

(2015) Elke Albrecht et al.   Scientific Reports

Association of circulating irisin and cardiopulmonary exercise capacity in healthy volunteers: results of the Study of Health in Pomerania

(2015) Nils Kerstholt et al.   BMC Pulmonary Medicine

High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects

(2014) G. Sesti et al.   ACTA DIABETOLOGICA

FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs

(2014) Fabian Sanchis-Gomar et al.   AGE

Serum Irisin Levels, Precocious Myocardial Infarction, and Healthy Exceptional Longevity

(2014) Enzo Emanuele et al.   AMERICAN JOURNAL OF MEDICINE

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Irisin: ‘fat’ or artefact

(2014) A.B. Crujeiras et al.   CLINICAL ENDOCRINOLOGY

Characterization of the metabolic effects of irisin on skeletal musclein vitro

(2014) R. A. Vaughan et al.   DIABETES OBESITY & METABOLISM

Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women

(2014) S. Ellefsen et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects

(2014) Stella S Daskalopoulou et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Irisin Is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise

(2014) Julia Brenmoehl et al.   International Journal of Biological Sciences

Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

(2014) J Y Huh et al.   INTERNATIONAL JOURNAL OF OBESITY

Thermogenic Capacity Is Antagonistically Regulated in Classical Brown and White Subcutaneous Fat Depots by High Fat Diet and Endurance Training in Rats

(2014) Michelle V. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating Irisin in Healthy, Young Individuals: Day-Night Rhythm, Effects of Food Intake and Exercise, and Associations With Gender, Physical Activity, Diet, and Body Composition

(2014) Athanasios D. Anastasilakis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Exercise-Induced Irisin Secretion Is Independent of Age or Fitness Level and Increased Irisin May Directly Modulate Muscle Metabolism Through AMPK Activation

(2014) Joo Young Huh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ursolic Acid-Induced Elevation of Serum Irisin Augments Muscle Strength During Resistance Training in Men

(2014) Hyun Seok Bang et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Irisin Does Not Mediate Resistance Training–Induced Alterations in Resting Metabolic Rate

(2014) FRIEDERIKE SCHARHAG-ROSENBERGER et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels

(2014) Kumpei Tanisawa et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin in response to acute and chronic whole-body vibration exercise in humans

(2014) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of aged garlic extract and endurance exercise on skeletal muscle FNDC-5 and circulating irisin in high-fat-diet rat models

(2014) Dae Yun Seo et al.   Nutrition Research and Practice

Exercise-mimicking treatment fails to increase Fndc5 mRNA & irisin secretion in primary human myotubes

(2014) Timea Kurdiova et al.   PEPTIDES

High-Intensity Exercise Causes Greater Irisin Response Compared with Low-Intensity Exercise under Similar Energy Consumption

(2014) Yoshifumi Tsuchiya et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial

(2014) Timm Greulich et al.   BMC Pulmonary Medicine

Irisin and exercise training in humans – Results from a randomized controlled training trial

(2013) Anne Hecksteden et al.   BMC Medicine

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans

(2013) Maria T Vamvini et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans

(2013) Frode Norheim et al.   FEBS Journal

Short-term high-intensity interval exercise training attenuates oxidative stress responses and improves antioxidant status in healthy humans

(2013) G.C. Bogdanis et al.   FOOD AND CHEMICAL TOXICOLOGY

Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine

(2013) A Besse-Patin et al.   INTERNATIONAL JOURNAL OF OBESITY

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

(2013) Maria A. Schumacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Are skeletal muscleFNDC5gene expression and irisin release regulated by exercise and related to health?

(2013) Satu Pekkala et al.   JOURNAL OF PHYSIOLOGY-LONDON

Saturated fatty acid palmitate-induced insulin resistance is accompanied with myotube loss and the impaired expression of health benefit myokine genes in C2C12 myotubes

(2013) Ming Yang et al.   Lipids in Health and Disease

Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs

(2013) John N. Fain et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Diet quality is associated with circulating C-reactive protein but not irisin levels in humans

(2013) Kyung Hee Park et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Free fatty acid effects on myokine production in combination with exercise mimetics

(2013) Juana Sánchez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

(2013) Suna Aydin et al.   PEPTIDES

BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis

(2013) Shu-Wen Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Irisin and FNDC5 in retrospect

(2013) Harold P Erickson   Adipocyte

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Expression of the Irisin Precursor FNDC5 in Skeletal Muscle Correlates With Aerobic Exercise Performance in Patients With Heart Failure

(2012) Stewart H. Lecker et al.   Circulation-Heart Failure

From white to brown fat through the PGC-1 -dependent myokine irisin: implications for diabetes and obesity

(2012) J. I. Castillo-Quan   Disease Models & Mechanisms

Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle

(2012) Jonathan D. Bartlett et al.   JOURNAL OF APPLIED PHYSIOLOGY

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Is irisin a human exercise gene?

(2012) James A. Timmons et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Exercise as a new physiological stimulus for brown adipose tissue activity

(2012) R. De Matteis et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index

(2012) Andreas Stengel et al.   PEPTIDES

Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue

(2011) Xiaohua Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences

(2011) Ivaylo P. Ivanov et al.   NUCLEIC ACIDS RESEARCH

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE