Article
Nutrition & Dietetics
Ammar Hassanzadeh Keshteli, Rosica Valcheva, Cheryl Nickurak, Heekuk Park, Rupasri Mandal, Kendall van Diepen, Karen I. Kroeker, Sander Veldhuyzen van Zanten, Brendan Halloran, David S. Wishart, Karen L. Madsen, Levinus A. Dieleman
Summary: The study reveals that dietary modifications, including increased intake of anti-inflammatory foods and decreased intake of pro-inflammatory foods, are associated with metabolic and microbial changes in ulcerative colitis patients in clinical remission, effectively preventing subclinical inflammation.
Article
Biochemistry & Molecular Biology
Aleksandra Danielak, Dagmara Wojcik, Agnieszka Mazur-Bialy, Marcin Surmiak, Jan Bilski, Aneta Targosz, Marcin Magierowski, Anna Chmura, Malgorzata Strzalka, Gracjana Krzysiek-Maczka, Katarzyna Magierowska, Urszula Szczyrk, Slawomir Kwiecien, Agata Ptak-Belowska, Tomasz Brzozowski
Summary: Moderate exercise combined with oral IAP treatment synergistically promotes intestinal inflammation healing, enhances antioxidant defense, and ameliorates the course of experimental colitis.
Review
Cell Biology
Xiaohua Liu, Yuxiang Du, Zhonghan Zhao, Jun Zou, Xiaojing Zhang, Lingli Zhang
Summary: White adipose tissue (WAT) functions as both an energy storage reservoir and a metabolically active endocrine organ. It can secrete various adipocytokines and synthesize and secrete exosomes, which play important roles in intercellular communication and physiological processes. The skeleton, on the other hand, acts as a protective organ, gives the body its shape, and is regulated by cytokines secreted by WAT. The link between WAT and bone lipid regulation has been identified, suggesting potential targets for treating skeletal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Ailsa Hart, Peter Bossuyt, Millie Long, Matthieu Allez, Pascal Juillerat, Alessandro Armuzzi, Edward Loftus, Elham Ostad-Saffari, Astrid Scalori, Young S. Oh, Swati Tole, Akiko Chai, Jennifer Pulley, Stuart Lacey, William J. Sandborn
Summary: This study evaluated the efficacy and safety of etrolizumab in patients with moderately to severely active ulcerative colitis who had been previously treated with anti-TNF agents. The results showed that etrolizumab significantly improved remission rates at week 14 compared to placebo, but there was no significant difference between the two groups in remission rates at week 66.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Immunology
Qiongyu Li, Fantao Meng, Xiangxian Ma, Zhe Sun, Juanjuan Dai, Jing Liu, Dan Li, Peijia Cong, Ruixue Xu, Di Zhao, Wentao Wang, Dan Wang, Cuilan Liu, Faxiang Wang, Chen Li, Haifeng Lian
Summary: In this study, it was found that the incidence rate of IBD increased before or after the COVID-19 epidemic, with higher GAD-7 scores and poorer GIQLI in patients. The dysfunctional up-regulation of IL-19 in the colon was identified as a key factor in the comorbidities of colitis and anxiety, affecting different signaling pathways in the colon and hippocampus.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Arlou Kristina Angeles, Florian Janke, Ann-Kathrin Daum, Martin Reck, Marc A. Schneider, Michael Thomas, Petros Christopoulos, Holger Sueltmann
Summary: This study investigated the potential biomarker value of circulating cytokines and circulating tumor DNA (ctDNA) in ALK-rearranged+ lung adenocarcinoma (ALK + NSCLC), and explored the optimal combination of molecular parameters that could indicate disease progression. The results showed that serum levels of IL-6, IL-8, and IL-10 were elevated in progressive disease, with IL-8 having the most significant impact as a biomarker. Integrating changes in IL-8 with ctDNA parameters maximized the performance of the classifiers in identifying disease progression, but did not significantly outperform the model based on ctDNA alone.
BRITISH JOURNAL OF CANCER
(2023)
Article
Microbiology
Bowei Zhang, Congying Zhao, Xuejiao Zhang, Xiang Li, Yunhui Zhang, Xiaoxia Liu, Jia Yin, Xinyang Li, Jin Wang, Shuo Wang
Summary: The prevalence of inflammatory bowel disease is increasing, causing a global burden. Certain amino acids have been found to be beneficial for mucosal healing and colitis remission. This study investigated the effects of diets enriched in amino acids and intact proteins on colitis in mice, revealing the critical role of gut microbiota in the prevention of colitis by an elemental diet.
Article
Immunology
Daiki Takezaki, Shin Morizane, Kenta Ikeda, Masanori Iseki, Yuma Sakamoto, Yoshio Kawakami, Taishi Hashiguchi, Yuka Shirakata, Sohji Nishina, Tomoyuki Mukai
Summary: This study explored the bidirectional association between non-alcoholic steatohepatitis (NASH) and psoriasis using a murine model. The results showed that NASH exacerbates psoriatic skin changes, accompanied by increased inflammatory cytokine levels and decreased adiponectin levels. Therefore, therapeutic intervention for co-occurring NASH is crucial for achieving a favorable prognosis of psoriasis in clinical practice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Claudia Savard, Simone Lemieux, Anne-Sophie Plante, Marianne Gagnon, Nadine Leblanc, Alain Veilleux, Andre Tchernof, Anne-Sophie Morisset
Summary: The study found that the natural inflammation occurring during pregnancy may be associated with adverse pregnancy outcomes. The concentrations of leptin, adiponectin, interleukin-6 (IL-6) and C-reactive protein (CRP) in the blood varied across trimesters of pregnancy. The Mediterranean diet score (MDS) was associated with leptin concentrations during the second trimester.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Gastroenterology & Hepatology
Dulari Jayawardena, Shubha Priyamvada, Takahiro Kageyama, Zachary White, Anoop Kumar, Theodor F. Griggs, Apurba Majumder, Ramsha Akram, Arivarasu N. Anbazhagan, Teruyuki Sano, Pradeep K. Dudeja
Summary: The down-regulation of chloride transporter SLC26A3 in colonocytes is associated with the pathogenesis of ulcerative colitis (UC) by triggering a type 2 immune response through IL-33 release, which is a result of altered epithelial-immune cell crosstalk.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Alexandros O. Konstantinidis, Katerina K. Adamama-Moraitou, Dimitra Pardali, Chrysostomos I. Dovas, Georgia D. Brellou, Theologos Papadopoulos, Albert E. Jergens, Karin Allenspach, Timoleon S. Rallis
Summary: This study investigated cytokine expression in canine large intestinal inflammatory bowel disease (IBD) and found that IL-1 beta, IL-23p19, and CCL28 may play a role in its pathogenesis, with clinical signs reflecting the severity of endoscopic lesions. Colonic cytokine expression did not correlate with clinical disease activity, but IL-1 beta, IL-23p19, and CCL28 were significantly increased in the colonic mucosa of dogs with IBD compared to healthy controls.
Article
Biology
Areej A. Eskandrani
Summary: The study demonstrated that dietary supplementation with fava bean could significantly improve the incidence of UC in rats, correct impaired oxidative and inflammatory biomarker levels, and modulate histological features and DNA alterations.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Polychronis Pavlidis, Anastasia Tsakmaki, Agatha Treveil, Katherine Li, Domenico Cozzetto, Feifei Yang, Umar Niazi, Bu Hussain Hayee, Mansoor Saqi, Joshua Friedman, Tamas Korcsmaros, Gavin Bewick, Nick Powell
Summary: In this study, the transcriptional landscape of human colonic epithelial organoids in response to different cytokines was mapped, revealing shared and distinct regulation patterns of epithelial function. The analysis of diseased tissue from IBD patients identified a molecular classification of mucosal inflammation and potential therapeutic targets in intestinal inflammation.
Article
Environmental Sciences
Bellipady Shyam Prasad Shetty, Sindaghatta Krishnarao Chaya, Sravan Kumar, Maheswarappa Mahendra, Biligere Siddaiah Jayaraj, Komarla Sundararaja Lokesh, Koustav Ganguly, Padukudru Anand Mahesh
Summary: In COPD patients, serum levels of both IL-1 beta and TNF-alpha are higher compared to healthy controls. There is a significant difference in TNF-alpha levels between TS-COPD and BMS-COPD, with TS-COPD patients having much higher levels. IL-1 beta levels are higher in BMS-COPD and correlate better with the severity of airflow limitation.
Article
Pharmacology & Pharmacy
Hassan Maleki, Maryam Doostan, Mohammad Hosein Farzaei, Parisa Seifi, Shahram Miraghaee, Mahtab Doostan
Summary: This study aimed to formulate a colon-specific delivery system for A. wilhelmsii extract using chitosan nanoparticles and Eudragit S100. The prepared nanoparticles showed spherical shape, suitable size, and high encapsulation efficiency. They exhibited a pH-sensitive release pattern and effectively mitigated UC-related inflammation and colonic lesions.
Article
Biochemistry & Molecular Biology
Urszula Glowacka, Katarzyna Magierowska, Dagmara Wojcik, Jerzy Hankus, Malgorzata Szetela, Jakub Cieszkowski, Edyta Korbut, Aleksandra Danielak, Marcin Surmiak, Anna Chmura, John L. Wallace, Marcin Magierowski
Summary: The study showed that ATB-352 has better gastrointestinal safety compared to ketoprofen after long-term treatment, maintaining gastrointestinal function by releasing H2S. Compared to ketoprofen, ATB-352 has a smaller impact on intestinal microbiome and molecular sensors and effectively inhibits cyclooxygenase activity.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Environmental Sciences
Kamila Stachyra, Anna Wisniewska, Anna Kiepura, Katarzyna Kus, Filip Rolski, Klaudia Czepiel, Lukasz Chmura, Grzegorz Majka, Marcin Surmiak, Justyna Polaczek, Rudi van Eldik, Maciej Suski, Rafal Olszanecki
Summary: This study investigated the effect of silica and ferric oxide nanoparticles on the development of atherosclerosis, finding that inhaled silica nanoparticles increased atherosclerotic lesions, while exposure to ferric oxide nanoparticles caused significant changes in plaque composition. Both nanoparticles altered the phenotype of T lymphocytes in the spleen.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Immunology
Marcin Surmiak, Katarzyna Wawrzycka-Adamczyk, Joanna Kosalka-Wegiel, Stanisnaw Polanski, Marek Sanak
Summary: This study characterized the profile of microRNAs trafficked by extracellular vesicles (EVs) in patients with granulomatosis with polyangiitis (GPA). Four differentially expressed microRNAs were identified in EVs from GPA patients, with miR-223-3p being the best discriminator between GPA patients and healthy controls. MiR-664a-3p was able to discriminate between active and remission phases of GPA. The correct classification rate based on multivariate discriminant analysis was 92% for acute phase and 85% for all study participants. Pathway analysis revealed potential target genes of these microRNAs, involved in focal adhesion, mTOR signaling, and neutrophil extracellular traps formation. Two microRNAs positively correlated with disease activity were found to be involved in neutrophil extracellular traps formation and apoptosis inhibition.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dagmara Wojcik-Grzybek, Magdalena Hubalewska-Mazgaj, Marcin Surmiak, Zbigniew Sliwowski, Anna Dobrut, Agata Mlodzinska, Adrianna Wojcik, Slawomir Kwiecien, Marcin Magierowski, Agnieszka Mazur-Bialy, Jan Bilski, Tomasz Brzozowski
Summary: In this study, it was found that obesity and sedentary lifestyle worsened colitis in mice, while supplementation with intestinal alkaline phosphatase (IAP) and moderate physical activity attenuated the severity of colitis in obese mice. This improvement may be achieved through downregulation of the intestinal cytokine/chemokine network and oxidative stress, modulation of gut microbiota, and improvement of muscle strength.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Gabriela Patla, Agnieszka I. I. Mazur-Bialy, Magdalena Humaj-Grysztar, Joanna Bonior
Summary: This study examined the severity of vulvar pain and its impact on quality of life in a group of Polish women. It was found that vulvodynia mainly affects young, highly educated, and unmarried women, divorcees, and widows. The disease significantly reduces quality of life, mainly due to difficulties in daily activities and decreased sexual satisfaction. The severity of pain is negatively correlated with quality of life. Continued research in this area is recommended.
Article
Biochemistry & Molecular Biology
Anna Dobrut, Agata Mlodzinska, Kamil Drozdz, Dagmara Wojcik-Grzybek, Katarzyna Michalak, Dorota Pietras-Ozga, Jolanta Karakulska, Katarzyna Biegun, Monika Brzychczy-Wloch
Summary: Bovine mastitis is a common and costly disease for dairy cattle breeders worldwide. This study aimed to detect and characterize the fibronectin binding protein A (FnBPA) of Staphylococcus aureus (SA) in milk samples from cows with mastitis. Bioinformatic analysis identified FnBPA as a potential biomarker for bovine SA. Immunoblotting confirmed the presence and immunoreactivity of FnBPA, suggesting it could be a valuable biomarker for mastitis immunodiagnostics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Agnieszka Mazur-Bialy, Sabina Tim, Daria Kolomanska-Bogucka, Bartlomiej Burzynski, Tomasz Jurys, Natalia Plawiak
Summary: Urinary incontinence is a serious health issue that affects both men and women. Physiotherapeutic methods, such as pelvic floor muscle training, biofeedback, and electrostimulation, are effective in treating male urinary incontinence. However, the effectiveness of these methods varies across studies, making it difficult to draw definitive conclusions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biology
Agnieszka Wnuk-Scardaccione, Klaudia Zawojska, Marta Barlowska-Trybulec, Agnieszka Irena Mazur-Bialy
Summary: Low back pain is a common and long-lasting problem in prostheses users after lower limb amputation. This systematic review found that exercise therapy has the potential to be a treatment strategy for low back pain among amputees. However, the study's major limitation is the heterogeneity of the subject group. More high-quality research is needed to establish a consensus on exercise intervention.
Article
Biochemistry & Molecular Biology
Urszula Glowacka, Marcin Magierowski, Zbigniew Sliwowski, Jakub Cieszkowski, Malgorzata Szetela, Dagmara Wojcik-Grzybek, Anna Chmura, Tomasz Brzozowski, John L. Wallace, Katarzyna Magierowska
Summary: ATB-344, a novel H2S-releasing indomethacin derivative, has been found to effectively protect gastric mucosa and enhance the barrier capacity against acute oxidative injury. Compared to classic indomethacin, ATB-344 reduces gastric mucosal damage and maintains cytoprotective functions, making it a potential therapeutic option for gastritis and inflammation-related conditions like osteoarthritis.
Review
Obstetrics & Gynecology
Weronika Milka, Weronika Paradowska, Daria Kolomanska-Bogucka, Agnieszka I. Mazur-Bialy
Summary: This review assessed the impact of antenatal perineal massage (APM) on perinatal perineal injuries and the development of pelvic pain and other complications in postpartum women. The findings showed that APM can reduce the risk of perineal injuries and pain during childbirth, as well as decrease the risk of fecal and gas incontinence in the postpartum period.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2023)
Review
Biochemistry & Molecular Biology
Jan Bilski, Agata Schramm-Luc, Marian Szczepanik, Agnieszka Irena Mazur-Bialy, Joanna Bonior, Kevin Luc, Klaudia Zawojska, Joanna Szklarczyk
Summary: This article summarizes the roles of adipokines in rheumatoid arthritis (RA), explores the crosstalk between adipose tissue and skeletal muscle, and discusses the emerging role of adipomyokines in the pathogenesis of RA and their therapeutic potential.
Meeting Abstract
Gastroenterology & Hepatology
Dagmara Wojcik-Grzybek, Marcin Surmiak, Slawomir Kwiecien, Zbigniew Sliwowski, Marcin Magierowski, Jan Bilski, Agnieszka I. Mazur-Bialy, Aneta Targosz, Katarzyna Magierowska, Agata Ptak-Belowska, Tomasz Brzozowski
Article
Medicine, General & Internal
Michal Wegiel, Joanna Wojtasik-Bakalarz, Krzysztof Malinowski, Marcin Surmiak, Artur Dziewierz, Danuta Sorysz, Tomasz Tokarek, Dariusz Dudek, Stanislaw Bartus, Andrzej Surdacki, Tomasz Rakowski
Summary: This study assessed the relationship between circulating biomarkers and left ventricular function after myocardial infarction (MI). The results indicate that LDH and MR-pro ADM may be promising biomarkers of adverse remodeling, and higher levels of these biomarkers are associated with a reduced chance of favorable reverse remodeling occurrence in MI patients.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2022)