Regulating the human HECT E3 ligases

Structural mechanisms of HECT-type ubiquitin ligases

(2018) Sonja Lorenz   BIOLOGICAL CHEMISTRY

The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome

(2017) Jason J. Yi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Tunable Brake for HECT Ubiquitin Ligases

(2017) Zan Chen et al.   MOLECULAR CELL

The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness

(2017) Amrita Singh Chandhoke et al.   Oncotarget

A conformational switch regulates the ubiquitin ligase HUWE1

(2017) Bodo Sander et al.   eLife

The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function

(2017) Shan He et al.   Scientific Reports

Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation

(2016) Jingyi Shu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

E2 enzymes: more than just middle men

(2016) Mikaela D Stewart et al.   CELL RESEARCH

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

Functional and pathological relevance of HERC family proteins: a decade later

(2016) Susana Sánchez-Tena et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Itch promotes the neddylation of JunB and regulates JunB-dependent transcription

(2016) Haiwen Li et al.   CELLULAR SIGNALLING

Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response

(2016) Xiaoliang Liu et al.   FEBS LETTERS

ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding

(2016) Ziying Han et al.   JOURNAL OF VIROLOGY

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

(2016) Wei Zhang et al.   MOLECULAR CELL

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

(2016) Denise Martinez-Zapien et al.   NATURE

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity

(2016) Nicolas Huguenin-Dezot et al.   Cell Reports

Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin

(2016) Eunju Im et al.   Open Biology

Analysis of Multiple HPV E6 PDZ Interactions Defines Type-Specific PDZ Fingerprints That Predict Oncogenic Potential

(2016) Miranda Thomas et al.   PLoS Pathogens

An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A

(2015) Jason J. Yi et al.   CELL

The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial–mesenchymal transition in a sumoylation-regulated manner

(2015) A S Chandhoke et al.   CELL DEATH AND DIFFERENTIATION

Expanding the ubiquitin code through post-translational modification

(2015) L. Herhaus et al.   EMBO REPORTS

Ubiquitin-specific protease 7 accelerates p14ARFdegradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression

(2015) Jia-Bin Cai et al.   HEPATOLOGY

Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation

(2015) Christopher Riling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism

(2015) Stefan G. Kathman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein neddylation: beyond cullin–RING ligases

(2015) Radoslav I. Enchev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death

(2015) C K Lee et al.   ONCOGENE

Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination

(2015) Franziska Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy

(2015) Ketaki Ganti et al.   Viruses-Basel

Identification and Characterization of Small Molecule Human Papillomavirus E6 Inhibitors

(2014) Kimberly A. Malecka et al.   ACS Chemical Biology

Neutron-Encoded Mass Signatures for Quantitative Top-Down Proteomics

(2014) Timothy W. Rhoads et al.   ANALYTICAL CHEMISTRY

Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8

(2014) Daniel C. Scott et al.   CELL

Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses

(2014) Z. Han et al.   JOURNAL OF VIROLOGY

Autoregulation of the 26S proteasome by in situ ubiquitination

(2014) Andrew D. Jacobson et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity

(2014) A. Persaud et al.   Science Signaling

Structural Basis of the Activation and Degradation Mechanisms of the E3 Ubiquitin Ligase Nedd4L

(2014) Albert Escobedo et al.   STRUCTURE

The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis

(2014) Ping Xie et al.   Nature Communications

c-Abl Phosphorylates E6AP and Regulates Its E3 Ubiquitin Ligase Activity

(2013) Ai-Leen Chan et al.   BIOCHEMISTRY

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

(2013) Meredith B. Metzger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mammalian HECT ubiquitin-protein ligases: Biological and pathophysiological aspects

(2013) Martin Scheffner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Building and remodelling Cullin-RING E3 ubiquitin ligases

(2013) John R Lydeard et al.   EMBO REPORTS

Development of inhibitors in the ubiquitination cascade

(2013) Wei Zhang et al.   FEBS LETTERS

The Active Form of E6-associated protein (E6AP)/UBE3A Ubiquitin Ligase Is an Oligomer

(2013) Virginia P. Ronchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins

(2013) K. Zanier et al.   SCIENCE

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

(2013) Hari B Kamadurai et al.   eLife

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

(2012) Jason Howitt et al.   JOURNAL OF CELL BIOLOGY

Conserved Region 3 of Human Papillomavirus 16 E7 Contributes to Deregulation of the Retinoblastoma Tumor Suppressor

(2012) B. Todorovic et al.   JOURNAL OF VIROLOGY

HERC6 Is the Main E3 Ligase for Global ISG15 Conjugation in Mouse Cells

(2012) Diede Oudshoorn et al.   PLoS One

Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions

(2012) D. Y.-w. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-β Pathways

(2012) Eric Aragón et al.   STRUCTURE

ESpritz: accurate and fast prediction of protein disorder

(2011) Ian Walsh et al.   BIOINFORMATICS

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

(2011) P de Bie et al.   CELL DEATH AND DIFFERENTIATION

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

(2011) Elena Maspero et al.   EMBO REPORTS

Structure and function of a HECT domain ubiquitin-binding site

(2011) Hyung Cheol Kim et al.   EMBO REPORTS

Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity

(2011) Maoyuan Tian et al.   FEBS LETTERS

Physical and Functional Interaction of the HECT Ubiquitin-protein Ligases E6AP and HERC2

(2011) Simone Kühnle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A

(2011) Alexander Lemak et al.   JOURNAL OF BIOMOLECULAR NMR

Regulation of the Human Papillomavirus Type 18 E6/E6AP Ubiquitin Ligase Complex by the HECT Domain-Containing Protein EDD

(2011) V. Tomaic et al.   JOURNAL OF VIROLOGY

Cdh1 Is a HECT of an Activator

(2011) Luying Jia et al.   MOLECULAR CELL

Cdh1 Regulates Osteoblast Function through an APC/C-Independent Modulation of Smurf1

(2011) Lixin Wan et al.   MOLECULAR CELL

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Interferon-Stimulated Gene 15 and the Protein ISGylation System

(2010) Dongxian Zhang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

(2010) Delin Chen et al.   NATURE

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

(2010) Cheol-Sang Hwang et al.   NATURE CELL BIOLOGY

Regulation of the RSP5 Ubiquitin Ligase by an Intrinsic Ubiquitin-binding Site

(2009) Michael E. French et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ubiquitin Binding Region of the Smurf HECT Domain Facilitates Polyubiquitylation and Binding of Ubiquitylated Substrates

(2009) Abiodun A. Ogunjimi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyubiquitination by HECT E3s and the Determinants of Chain Type Specificity

(2009) H. C. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex

(2009) Hari B. Kamadurai et al.   MOLECULAR CELL

Itch self-polyubiquitylation occurs through lysine-63 linkages

(2008) Flavia Scialpi et al.   BIOCHEMICAL PHARMACOLOGY

HPV E6, E6AP and cervical cancer

(2008) Sylvie Beaudenon et al.   BMC BIOCHEMISTRY

The ubiquitin system, disease, and drug discovery

(2008) Matthew D Petroski   BMC BIOCHEMISTRY

Tenets of PTEN Tumor Suppression

(2008) Leonardo Salmena et al.   CELL

ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response

(2008) Oxana A. Malakhova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity

(2008) A. Okumura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA