Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response

USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168*

(2015) Qianzheng Zhu et al.   CELL CYCLE

Polo-like kinase 1 inhibits DNA damage response during mitosis

(2015) Jan Benada et al.   CELL CYCLE

Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells

(2015) Xiufang Song et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling

(2015) Zizhang Zhou et al.   DEVELOPMENTAL CELL

Deubiquitinases and the new therapeutic opportunities offered to cancer

(2015) R. Pfoh et al.   ENDOCRINE-RELATED CANCER

Ubiquitin-specific protease 7 accelerates p14ARFdegradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression

(2015) Jia-Bin Cai et al.   HEPATOLOGY

Annexin-1 regulated by HAUSP is essential for UV-induced damage response

(2015) J-J Park et al.   Cell Death & Disease

The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death

(2015) Florian J. Bock et al.   Scientific Reports

USP7 controls Chk1 protein stability by direct deubiquitination

(2014) Ignacio Alonso-de Vega et al.   CELL CYCLE

Controlling ARF stability

(2014) Omid Tavana et al.   CELL CYCLE

The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of  -Catenin

(2014) P. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF

(2014) D Lo et al.   ONCOGENE

Regulation of 53BP1 Protein Stability by RNF8 and RNF168 Is Important for Efficient DNA Double-Strand Break Repair

(2014) Yiheng Hu et al.   PLoS One

UbcH7 regulates 53BP1 stability and DSB repair

(2014) Xiangzi Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

(2013) Elsa Callen et al.   CELL

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

(2013) James A Nathan et al.   EMBO JOURNAL

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

(2013) Georgia Velimezi et al.   NATURE CELL BIOLOGY

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks

(2013) M. Bohgaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells

(2013) Chung-Il An et al.   Skeletal Muscle

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

(2012) Thorkell Gudjonsson et al.   CELL

ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage

(2012) Svetlana V. Khoronenkova et al.   MOLECULAR CELL

The Multifaceted Roles of USP7: New Therapeutic Opportunities

(2011) Benjamin Nicholson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

(2011) Allan M. Weissman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The TRIP from ULF to ARF

(2010) Manuel Collado et al.   CANCER CELL

Reactivating the ARF-p53 axis in AML cells by targeting ULF

(2010) Delin Chen et al.   CELL CYCLE

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

(2010) Delin Chen et al.   NATURE

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY