WWP2 is an E3 ubiquitin ligase for PTEN

Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53

(2010) Xin He et al.   HUMAN MOLECULAR GENETICS

Rak Functions as a Tumor Suppressor by Regulating PTEN Protein Stability and Function

(2009) Eun-Kyoung Yim et al.   CANCER CELL

PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers

(2009) Guang Jin et al.   LUNG CANCER

The HECT-Type E3 Ubiquitin Ligase AIP2 Inhibits Activation-Induced T-Cell Death by Catalyzing EGR2 Ubiquitination

(2009) A. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase

(2009) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications

(2008) Amancio Carnero et al.   CURRENT CANCER DRUG TARGETS

PTEN hamartoma tumor syndromes

(2008) Gideon M Blumenthal et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Post-translational regulation of PTEN

(2008) X Wang et al.   ONCOGENE

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

(2008) F. Fouladkou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool

(2008) P. Reddy et al.   SCIENCE