Metreleptin and generalized lipodystrophy and evolving therapeutic perspectives

Leptin treatment: Facts and expectations

(2015) Gilberto Paz-Filho et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Biologically Inactive Leptin and Early-Onset Extreme Obesity

(2015) Martin Wabitsch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

(2015) Md. Mesbah Uddin Talukder et al.   Molecular Metabolism

Leptin replacement therapy for the treatment of non-HAART associated lipodystrophy syndromes: a meta-analysis into the effects of leptin on metabolic and hepatic endpoints

(2014) Alexander J. Rodríguez et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Towards a mechanistic understanding of lipodystrophy and seipin functions

(2014) Kenneth Wee et al.   BIOSCIENCE REPORTS

Effects of Leptin Replacement Therapy on Pancreatic β-Cell Function in Patients With Lipodystrophy

(2014) Ranganath Muniyappa et al.   DIABETES CARE

The neuroanatomical function of leptin in the hypothalamus

(2014) M.M.H. van Swieten et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Bone Mineral Content in Patients With Congenital Generalized Lipodystrophy Is Unaffected by Metreleptin Replacement Therapy

(2014) John D. Christensen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Direct and indirect effects of leptin on adipocyte metabolism

(2013) Ruth B.S. Harris   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metreleptin: First Global Approval

(2013) Ken Chou et al.   DRUGS

Teasaponin Reduces Inflammation and Central Leptin Resistance in Diet-Induced Obese Male Mice

(2013) Yinghua Yu et al.   ENDOCRINOLOGY

Acquired generalized lipodystrophy associated with peripheral T cell lymphoma with cutaneous infiltration

(2013) Arif Aslam et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

The liver diseases of lipodystrophy: The long-term effect of leptin treatment

(2013) Elika Safar Zadeh et al.   JOURNAL OF HEPATOLOGY

Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies

(2013) Tom Nolis   JOURNAL OF HUMAN GENETICS

Randomized double-blind placebo-controlled study of leptin administration after gastric bypass

(2013) Judith Korner et al.   Obesity

Leptin signaling and leptin resistance

(2013) Yingjiang Zhou et al.   Frontiers of Medicine

Lysophospholipid acyltransferases

(2012) Anil K. Agarwal   CURRENT OPINION IN LIPIDOLOGY

Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21

(2012) Timo D. Müller et al.   JOURNAL OF PEPTIDE SCIENCE

Leptin replacement therapy does not improve the abnormal lipid kinetics of hypoleptinemic patients with HIV-associated lipodystrophy syndrome

(2012) Rajagopal V. Sekhar et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The role of leptin in glucose homeostasis

(2012) Heather C Denroche et al.   Journal of Diabetes Investigation

The role of leptin in human lipid and glucose metabolism: the effects of acute recombinant human leptin infusion in young healthy males

(2011) Emil Wolsk et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Leptin in human physiology and pathophysiology

(2011) Christos S. Mantzoros et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance

(2011) H.-S. Moon et al.   DIABETES

Clinical Effects of Long-Term Metreleptin Treatment in Patients with Lipodystrophy

(2011) Jean Chan et al.   Endocrine Practice

Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet

(2011) Greeshma K Shetty et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Lipodystrophies: Genetic and Acquired Body Fat Disorders

(2011) Abhimanyu Garg   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Comparison of Efficacy and Safety of Leptin Replacement Therapy in Moderately and Severely Hypoleptinemic Patients with Familial Partial Lipodystrophy of the Dunnigan Variety

(2011) Vinaya Simha et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of leptin and adiponectin on pancreatic β-cell function

(2011) Yong-ho Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Ten years of leptin replacement therapy

(2011) G. Paz-Filho et al.   Obesity Reviews

Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase

(2010) Youcai Tang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Roles of FoxO1 and Sirt1 in the central regulation of food intake

(2010) Tsutomu Sasaki et al.   ENDOCRINE JOURNAL

Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia

(2010) Jonathan P. German et al.   ENDOCRINOLOGY

Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus–infected lipoatrophic men treated with pioglitazone: a pilot study

(2010) Faidon Magkos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Lipodystrophy: pathophysiology and advances in treatment

(2010) Christina G. Fiorenza et al.   Nature Reviews Endocrinology

Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding

(2009) Gina M. Leinninger et al.   Cell Metabolism

Efficacy of leptin therapy in the different forms of human lipodystrophy

(2009) A. Y. Chong et al.   DIABETOLOGIA

The Effects of Recombinant Human Leptin on Visceral Fat, Dyslipidemia, and Insulin Resistance in Patients with Human Immunodeficiency Virus-Associated Lipoatrophy and Hypoleptinemia

(2009) Kathleen Mulligan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Enhanced Weight Loss With Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy

(2009) Eric Ravussin et al.   Obesity

Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients

(2008) Gilberto Paz-Filho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pharmacokinetics of Subcutaneous Recombinant Methionyl Human Leptin Administration in Healthy Subjects in the Fed and Fasting States

(2008) Jean L Chan et al.   CLINICAL PHARMACOKINETICS

Caveolin-1: A New Locus for Human Lipodystrophy

(2008) Abhimanyu Garg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM