Metreleptin: First Global Approval

W(h)ither Metreleptin for Lipodystrophy and the Metabolic Syndrome?

(2013) Christos S. Mantzoros   Endocrine Practice

Selective capacity of metreleptin administration to reconstitute CD4+T-cell number in females with acquired hypoleptinemia

(2013) Giuseppe Matarese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin replacement therapy does not improve the abnormal lipid kinetics of hypoleptinemic patients with HIV-associated lipodystrophy syndrome

(2012) Rajagopal V. Sekhar et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Leptin treatment reduces body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women

(2011) Mary Brinkoetter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance

(2011) H.-S. Moon et al.   DIABETES

Clinical Effects of Long-Term Metreleptin Treatment in Patients with Lipodystrophy

(2011) Jean Chan et al.   Endocrine Practice

Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet

(2011) Greeshma K Shetty et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Lipodystrophies: Genetic and Acquired Body Fat Disorders

(2011) Abhimanyu Garg   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Comparison of Efficacy and Safety of Leptin Replacement Therapy in Moderately and Severely Hypoleptinemic Patients with Familial Partial Lipodystrophy of the Dunnigan Variety

(2011) Vinaya Simha et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women

(2011) Elizabeth Sienkiewicz et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Leptin is an effective treatment for hypothalamic amenorrhea

(2011) S. H. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rationale for Leptin-Replacement Therapy for Severe Lipodystrophy

(2010) Elif Oral et al.   Endocrine Practice

Clinical Classification and Treatment of Congenital and Acquired Lipodystrophy

(2010) Jean Chan et al.   Endocrine Practice

Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus–infected lipoatrophic men treated with pioglitazone: a pilot study

(2010) Faidon Magkos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Lipodystrophy: pathophysiology and advances in treatment

(2010) Christina G. Fiorenza et al.   Nature Reviews Endocrinology

Efficacy of leptin therapy in the different forms of human lipodystrophy

(2009) A. Y. Chong et al.   DIABETOLOGIA

Enhanced Weight Loss With Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy

(2009) Eric Ravussin et al.   Obesity

Pharmacokinetics of Subcutaneous Recombinant Methionyl Human Leptin Administration in Healthy Subjects in the Fed and Fasting States

(2008) Jean L Chan et al.   CLINICAL PHARMACOKINETICS