Lipodystrophy: pathophysiology and advances in treatment

Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications

(2013) Theodore Kelesidis   ANNALS OF INTERNAL MEDICINE

Prolonged thiazolidinedione therapy does not reverse fat loss in patients with familial partial lipodystrophy, Dunnigan variety

(2010) V. Simha et al.   DIABETES OBESITY & METABOLISM

Rationale for Leptin-Replacement Therapy for Severe Lipodystrophy

(2010) Elif Oral et al.   Endocrine Practice

Resistance to leptin-replacement therapy in Berardinelli–Seip congenital lipodystrophy: an immunological origin

(2010) Jacques Beltrand et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells

(2010) Ana Blas-García et al.   HEPATOLOGY

A Meta-Analysis of Six Placebo-Controlled Trials of Thiazolidinedione Therapy for HIV Lipoatrophy

(2010) Janet M. Raboud et al.   HIV CLINICAL TRIALS

Effects of Tesamorelin, a Growth Hormone-Releasing Factor, in HIV-Infected Patients With Abdominal Fat Accumulation: A Randomized Placebo-Controlled Trial With a Safety Extension

(2010) Julian Falutz et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Higher Adiponectin Levels in Patients with Berardinelli-Seip Congenital Lipodystrophy due to Seipin as compared with 1-Acylglycerol-3-Phosphate-O-Acyltransferase-2 Deficiency

(2010) Barbara Antuna-Puente et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic analysis implicates resistin in HIV lipodystrophy

(2009) Koustubh Ranade et al.   AIDS

Zidovudine/lamivudine contributes to insulin resistance within 3 months of starting combination antiretroviral therapy

(2009) Regje ME Blümer et al.   AIDS

Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment

(2009) Richard H Haubrich et al.   AIDS

Assessment of Ultrasound for Use in Detecting Lipoatrophy in HIV-Infected Patients Taking Combination Antiretroviral Therapy

(2009) Klaudija Viskovic et al.   AIDS PATIENT CARE AND STDS

Lipodystrophies: Disorders of adipose tissue biology

(2009) Abhimanyu Garg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Drug-induced lipotoxicity: Lipodystrophy associated with HIV-1 infection and antiretroviral treatment

(2009) Francesc Villarroya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Seipin deficiency alters fatty acid Δ9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy

(2009) Emilie Boutet et al.   BIOCHIMIE

Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

(2009) Víctor A. Cortés et al.   Cell Metabolism

Long-term improvement of metabolic control with pioglitazone in a woman with diabetes mellitus related to Dunnigan syndrome: A case report

(2009) C. Collet-Gaudillat et al.   DIABETES & METABOLISM

Leptin therapy in lipodystrophy

(2009) D. B. Savage et al.   DIABETOLOGIA

Efficacy of leptin therapy in the different forms of human lipodystrophy

(2009) A. Y. Chong et al.   DIABETOLOGIA

Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation inCIDEC

(2009) Oscar Rubio-Cabezas et al.   EMBO Molecular Medicine

Rhabdomyolysis associated with fibrate therapy: review of 76 published cases and a new case report

(2009) Jianyong Wu et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Adherence to the Mediterranean diet is associated with a lower risk of body-shape changes in Croatian patients treated with combination antiretroviral therapy

(2009) Drago Turčinov et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

HIV-1 Protease Inhibitor Induced Oxidative Stress Suppresses Glucose Stimulated Insulin Release: Protection with Thymoquinone

(2009) Surabhi Chandra et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The Effect of Rosiglitazone on Insulin Sensitivity, Beta Cell Function, Bone Mineral Density, and Body Composition in HIV-positive Patients on Highly-active Antiretroviral Therapy (HAART)

(2009) K. Schindler et al.   HORMONE AND METABOLIC RESEARCH

The Effect of Individual Antiretroviral Drugs on Body Composition in HIV-Infected Persons Initiating Highly Active Antiretroviral Therapy

(2009) Judith C Shlay et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Whither Recombinant Human Leptin Treatment for HIV-Associated Lipoatrophy and the Metabolic Syndrome?

(2009) Christos S. Mantzoros   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Effects of Recombinant Human Leptin on Visceral Fat, Dyslipidemia, and Insulin Resistance in Patients with Human Immunodeficiency Virus-Associated Lipoatrophy and Hypoleptinemia

(2009) Kathleen Mulligan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy

(2009) Yukiko K. Hayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Gene Expression and Immunohistochemistry in Adipose Tissue of HIV Type 1–Infected Patients with Nucleoside Analogue Reverse‐Transcriptase Inhibitor–Associated Lipoatrophy

(2009) M. Sievers et al.   JOURNAL OF INFECTIOUS DISEASES

Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders

(2009) Isabelle Mercier et al.   LABORATORY INVESTIGATION

Hepatitis C, human immunodeficiency virus and metabolic syndrome: interactions

(2009) Donald P. Kotler   LIVER INTERNATIONAL

Clinical characteristics and efficacy of pioglitazone in a Japanese diabetic patient with an unusual type of familial partial lipodystrophy

(2009) Masanori Iwanishi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adherence to Mediterranean diet is favorably associated with metabolic parameters in HIV-positive patients with the highly active antiretroviral therapy–induced metabolic syndrome and lipodystrophy

(2009) Sotiris Tsiodras et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Long term adverse effects related to nucleoside reverse transcriptase inhibitors: Clinical impact of mitochondrial toxicity

(2009) Anne Maagaard et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Metformin Increases HDL3–Cholesterol and Decreases Subcutaneous Truncal Fat in Nondiabetic Patients with HIV-Associated Lipodystrophy

(2008) Leandro A. Diehl et al.   AIDS PATIENT CARE AND STDS

Novel subtype of congenital generalized lipodystrophy associated with muscular weakness and cervical spine instability

(2008) Vinaya Simha et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy

(2008) Ksenia Sevastianova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pharmacokinetics of Subcutaneous Recombinant Methionyl Human Leptin Administration in Healthy Subjects in the Fed and Fasting States

(2008) Jean L Chan et al.   CLINICAL PHARMACOKINETICS

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

(2008) V. A. Payne et al.   DIABETES

Monogenic polycystic ovary syndrome due to a mutation in the lamin A/C gene is sensitive to thiazolidinediones but not to metformin

(2008) A Gambineri et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: observational and interventional studies in humans

(2008) Aoife M Brennan et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus

(2008) Andressa Coope et al.   FEBS LETTERS

Treatment of Altered Body Composition in HIV-Associated Lipodystrophy: Comparison of Rosiglitazone, Pravastatin, and Recombinant Human Growth Hormone

(2008) Derek C. Macallan et al.   HIV CLINICAL TRIALS

European AIDS Clinical Society (EACS) guidelines on the prevention and management of metabolic diseases in HIV

(2008) JD Lundgren et al.   HIV MEDICINE

Low prevalence of insulin resistance among HIV-infected children receiving nonnucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy in Thailand

(2008) B Lee et al.   HIV MEDICINE

Low-Dose Physiological Growth Hormone in Patients With HIV and Abdominal Fat Accumulation

(2008) Janet Lo   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options

(2008) J. E. Mallewa et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Approach to the Human Immunodeficiency Virus-Infected Patient with Lipodystrophy

(2008) Todd T. Brown   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Effect of Strength and Endurance Training on Insulin Sensitivity and Fat Distribution in Human Immunodeficiency Virus-Infected Patients with Lipodystrophy

(2008) B. Lindegaard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fertility and Obstetrical Complications in Women withLMNA-Related Familial Partial Lipodystrophy

(2008) M. C. Vantyghem et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association of a Homozygous Nonsense Caveolin-1 Mutation with Berardinelli-Seip Congenital Lipodystrophy

(2008) C. A. Kim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies

(2008)   LANCET

Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia

(2008) Henian Cao et al.   Lipids in Health and Disease

Acquired partial lipodystrophy in an 11-year-old girl

(2008) Joanna Oswiecimska et al.   PEDIATRICS INTERNATIONAL

GH/GHRH axis in HIV lipodystrophy

(2008) Takara L. Stanley et al.   Pituitary

Leptin therapy for partial lipodystrophy linked to a PPAR-γ mutation

(2007) Jean-Marc Guettier et al.   CLINICAL ENDOCRINOLOGY

Human Immunodeficiency Virus (HIV)-1 Viral Protein R Suppresses Transcriptional Activity of Peroxisome Proliferator-Activated Receptor γ and Inhibits Adipocyte Differentiation: Implications for HIV-Associated Lipodystrophy

(2007) Shashi Shrivastav et al.   MOLECULAR ENDOCRINOLOGY