Towards a mechanistic understanding of lipodystrophy and seipin functions

Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA

(2014) Junfeng Bi et al.   Cell Metabolism

Seipin differentially regulates lipogenesis and adipogenesis through a conserved core sequence and an evolutionarily acquired C-terminus

(2013) Wulin Yang et al.   BIOCHEMICAL JOURNAL

Function of seipin: New insights from Bscl2/seipin knockout mouse models

(2013) Lucile Dollet et al.   BIOCHIMIE

Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms

(2013) M. F. Michelle Sim et al.   DIABETOLOGIA

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

(2013) X. Prieur et al.   DIABETOLOGIA

BSCL2/seipin regulates adipogenesis through actin cytoskeleton remodelling

(2013) Wulin Yang et al.   HUMAN MOLECULAR GENETICS

Role of seipin in lipid droplet morphology and hepatitis C virus life cycle

(2013) S. Clement et al.   JOURNAL OF GENERAL VIROLOGY

A new seipin-associated neurodegenerative syndrome

(2013) Encarna Guillén-Navarro et al.   JOURNAL OF MEDICAL GENETICS

Motor neuropathy-associated mutation impairs Seipin functions in neurotransmission

(2013) Shunhui Wei et al.   JOURNAL OF NEUROCHEMISTRY

Suppression of Adipogenesis by Pathogenic Seipin Mutant Is Associated with Inflammatory Response

(2013) Wenjie Qiu et al.   PLoS One

Motor neuron degeneration in a mouse model of seipinopathy

(2013) J Guo et al.   Cell Death & Disease

Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy

(2012) Xin Cui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Seipin: from human disease to molecular mechanism

(2012) Bethany R. Cartwright et al.   JOURNAL OF LIPID RESEARCH

Seipin regulates excitatory synaptic transmission in cortical neurons

(2012) Shunhui Wei et al.   JOURNAL OF NEUROCHEMISTRY

Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation

(2012) W. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

(2012) Noritaka Kawasaki et al.   Scientific Reports

The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1

(2012) M.F. Michelle Sim et al.   Molecular Metabolism

Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes

(2011) Nobuhiko Takahashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A role for seipin in lipid droplet dynamics and inheritance in yeast

(2011) H. Wolinski et al.   JOURNAL OF CELL SCIENCE

Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis

(2011) Weihua Fei et al.   JOURNAL OF LIPID RESEARCH

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Seipin Is a Discrete Homooligomer

(2010) Derk Binns et al.   BIOCHEMISTRY

Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome

(2010) Antonio Torrelo et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

A Taiwanese Boy With Congenital Generalized Lipodystrophy Caused by Homozygous Ile262fs Mutation in the BSCL2 Gene

(2010) Hsiu-Hui Huang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Lipin 1 Represses NFATc4 Transcriptional Activity in Adipocytes To Inhibit Secretion of Inflammatory Factors

(2010) H. B. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Pathology of Congenital Generalized Lipodystrophy in Agpat2–/– Mice

(2010) P. Vogel et al.   VETERINARY PATHOLOGY

Fatal Cardiac Arrhythmia and Long-QT Syndrome in a New Form of Congenital Generalized Lipodystrophy with Muscle Rippling (CGL4) Due to PTRF-CAVIN Mutations

(2010) Anna Rajab et al.   PLoS Genetics

Clinical and molecular aspects of Berardinelli–Seip Congenital Lipodystrophy (BSCL)

(2009) Karina Braga Gomes et al.   CLINICA CHIMICA ACTA

Novel mutations of the BSCL2 and AGPAT2 genes in 10 families with Berardinelli-Seip congenital generalized lipodystrophy syndrome

(2009) Debora M. Miranda et al.   CLINICAL ENDOCRINOLOGY

The Human Lipodystrophy Gene Product Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Plays a Key Role in Adipocyte Differentiation

(2009) Weiqin Chen et al.   ENDOCRINOLOGY

Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy

(2009) Yukiko K. Hayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Two Japanese infants with congenital generalized lipodystrophy due toBSCL2mutations

(2009) Atsushi Nishiyama et al.   PEDIATRICS INTERNATIONAL

Inflammation and adipose tissue macrophages in lipodystrophic mice

(2009) L. Herrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

(2008) Michelle M. Hill et al.   CELL

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

(2008) V. A. Payne et al.   DIABETES

Lipin1 Is a Key Factor for the Maturation and Maintenance of Adipocytes in the Regulatory Network with CCAAT/Enhancer-binding Protein α and Peroxisome Proliferator-activated Receptor γ2

(2008) Yoo-Kyung Koh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY

Association of a Homozygous Nonsense Caveolin-1 Mutation with Berardinelli-Seip Congenital Lipodystrophy

(2008) C. A. Kim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia

(2008) Henian Cao et al.   Lipids in Health and Disease