Anti-Cancer Drug Validation: the Contribution of Tissue Engineered Models

Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening

(2015) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

3D tissue-engineered bone marrow as a novel model to study pathophysiology and drug resistance in multiple myeloma

(2015) Pilar de la Puente et al.   BIOMATERIALS

Deconstructing the role of the ECM microenvironment on drug efficacy targeting MAPK signaling in a pre-clinical platform for cutaneous melanoma

(2015) Benjamin H. Blehm et al.   BIOMATERIALS

Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed “in vivo”

(2015) Christian Hirt et al.   BIOMATERIALS

Formation of stable small cell number three-dimensional ovarian cancer spheroids using hanging drop arrays for preclinical drug sensitivity assays

(2015) Shreya Raghavan et al.   GYNECOLOGIC ONCOLOGY

3D in vitro modeling of the central nervous system

(2015) Amy M. Hopkins et al.   PROGRESS IN NEUROBIOLOGY

Evaluating Biomaterial- and Microfluidic-Based 3D Tumor Models

(2015) Mariana R. Carvalho et al.   TRENDS IN BIOTECHNOLOGY

p21-Activated Kinase 1 Coordinates Aberrant Cell Survival and Pericellular Proteolysis in a Three-Dimensional Culture Model for Premalignant Progression of Human Breast Cancer

(2015) Quanwen Li et al.   NEOPLASIA

Bioengineering 3D environments for cancer models

(2014) Mireia Alemany-Ribes et al.   ADVANCED DRUG DELIVERY REVIEWS

3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions

(2014) Carsten Wenzel et al.   EXPERIMENTAL CELL RESEARCH

Current standing and future prospects for the technologies proposed to transform toxicity testing in the 21st century

(2014) Erwin van Vliet   ALTEX-Alternatives to Animal Experimentation

A bioengineered 3D ovarian cancer model for the assessment of peptidase–mediated enhancement of spheroid growth and intraperitoneal spread

(2013) Daniela Loessner et al.   BIOMATERIALS

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

(2013) Zhiyun Xu et al.   BIOMATERIALS

A short-term colorectal cancer sphere culture as a relevant tool for human cancer biology investigation

(2013) L-B Weiswald et al.   BRITISH JOURNAL OF CANCER

Three-dimensionally engineered biomimetic tissue models forin vitrodrug evaluation: delivery, efficacy and toxicity

(2013) Yvonne Peck et al.   Expert Opinion on Drug Delivery

Considerations on the development of a model of kidney bioengineering and regeneration in rats

(2013) Andrea Peloso et al.   Expert Review of Medical Devices

Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model

(2013) Anna T. Stratmann et al.   Molecular Oncology

Regeneration and experimental orthotopic transplantation of a bioengineered kidney

(2013) Jeremy J Song et al.   NATURE MEDICINE

Development of a High-Throughput Three-Dimensional Invasion Assay for Anti-Cancer Drug Discovery

(2013) Nikki A. Evensen et al.   PLoS One

Correction: Bioengineered 3D Human Kidney Tissue, a Platform for the Determination of Nephrotoxicity

(2013) Teresa M. DesRochers et al.   PLoS One

Spheroid culture as a tool for creating 3D complex tissues

(2013) Eelco Fennema et al.   TRENDS IN BIOTECHNOLOGY

Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing

(2013) H Vörsmann et al.   Cell Death & Disease

Upcoming strategies for the treatment of metastatic melanoma

(2012) Francesco Spagnolo et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays

(2012) Anna I. Astashkina et al.   BIOMATERIALS

Synthetic 3D multicellular systems for drug development

(2012) Markus Rimann et al.   CURRENT OPINION IN BIOTECHNOLOGY

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Engineering therapies in the CNS: What works and what can be translated

(2012) Andrew J. Shoffstall et al.   NEUROSCIENCE LETTERS

3D Porous Chitosan-Alginate Scaffolds: A New Matrix for Studying Prostate Cancer Cell-Lymphocyte Interactions In Vitro

(2012) Stephen J. Florczyk et al.   Advanced Healthcare Materials

Skin tissue engineering — In vivo and in vitro applications

(2011) Florian Groeber et al.   ADVANCED DRUG DELIVERY REVIEWS

Modeling Colon Adenocarcinomas in Vitro

(2011) Helmut Dolznig et al.   AMERICAN JOURNAL OF PATHOLOGY

Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform

(2011) Badriprasad Ananthanarayanan et al.   BIOMATERIALS

3D in vitro bioengineered tumors based on collagen I hydrogels

(2011) Christopher S. Szot et al.   BIOMATERIALS

Determining tamoxifen sensitivity using primary breast cancer tissue in collagen-based three-dimensional culture

(2011) Alexander D. Leeper et al.   BIOMATERIALS

Three-dimensional cancer-bone metastasis model using ex-vivo co-cultures of live calvarial bones and cancer cells

(2011) Paul Curtin et al.   BIOMATERIALS

Co-culture of stromal and erythroleukemia cells in a perfused hollow fiber bioreactor system as an in vitro bone marrow model for myeloid leukemia

(2011) Suaidah Binte Mohamed Usuludin et al.   BIOTECHNOLOGY AND BIOENGINEERING

Drug localization in different lung cancer phenotypes by MALDI mass spectrometry imaging

(2011) György Marko-Varga et al.   Journal of Proteomics

Generation of oxygen gradients in microfluidic devices for cell culture using spatially confined chemical reactions

(2011) Yung-Ann Chen et al.   LAB ON A CHIP

High drug attrition rates—where are we going wrong?

(2011) Lisa Hutchinson et al.   Nature Reviews Clinical Oncology

Melanoma Spheroids Grown Under Neural Crest Cell Conditions Are Highly Plastic Migratory/Invasive Tumor Cells Endowed with Immunomodulator Function

(2011) Kiran Ramgolam et al.   PLoS One

Radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr

(2011) Carlos A Fedrigo et al.   Radiation Oncology

Alginate based 3D hydrogels as an in vitro co-culture model platform for the toxicity screening of new chemical entities

(2011) Shih-Feng Lan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The bone marrow microenvironment and leukemia: biology and therapeutic targeting

(2011) Edward Allan R Sison et al.   Expert Review of Hematology

3D tumour models: novel in vitro approaches to cancer studies

(2011) Agata Nyga et al.   Journal of Cell Communication and Signaling

Regenerative medicine of the kidney

(2010) Laura Perin et al.   ADVANCED DRUG DELIVERY REVIEWS

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

(2010) Yi-Chung Tung et al.   ANALYST

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

Carvedilol in glioma treatment alone and with imatinib in vitro

(2010) Erguven   INTERNATIONAL JOURNAL OF ONCOLOGY

A Review of Three-Dimensional In Vitro Tissue Models for Drug Discovery and Transport Studies

(2010) Nelita T. Elliott et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia

(2010) Todd W Ridky et al.   NATURE MEDICINE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Ectopic Human Mesenchymal Stem Cell-Coated Scaffolds in NOD/SCID Mice: An In Vivo Model of the Leukemia Niche

(2010) Sarah R. Vaiselbuh et al.   TISSUE ENGINEERING PART C-METHODS

Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells

(2009) Lisa A. Gurski et al.   BIOMATERIALS

The development of a three-dimensional scaffold for ex vivo biomimicry of human acute myeloid leukaemia

(2009) Teresa Mortera Blanco et al.   BIOMATERIALS

Newly characterised ex vivo colospheres as a three-dimensional colon cancer cell model of tumour aggressiveness

(2009) L-B Weiswald et al.   BRITISH JOURNAL OF CANCER

Three-dimensionalin vitrocell biology models of ovarian and endometrial cancer

(2009) B.  Grun et al.   CELL PROLIFERATION

Elastin-derived peptides: Matrikines critical for glioblastoma cell aggressiveness in a 3-D system

(2009) Bérénice Coquerel et al.   GLIA

Multicellular spheroids in ovarian cancer metastases: Biology and pathology

(2009) Kristy Shield et al.   GYNECOLOGIC ONCOLOGY

Three-Dimensional Overlay Culture Models of Human Breast Cancer Reveal a Critical Sensitivity to Mitogen-Activated Protein Kinase Kinase Inhibitors

(2009) Q. Li et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates

(2009) D Yamazaki et al.   ONCOGENE

Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells

(2008) Ilya Serebriiskii et al.   MATRIX BIOLOGY

3-D Tumor Model forIn VitroEvaluation of Anticancer Drugs

(2008) Jayme L. Horning et al.   MOLECULAR PHARMACEUTICS

New dimensions in tumor immunology: what does 3D culture reveal?

(2008) Chantal Feder-Mengus et al.   TRENDS IN MOLECULAR MEDICINE

Hyaluronan hydrogel: An appropriate three-dimensional model for evaluation of anticancer drug sensitivity

(2007) Laurent David et al.   Acta Biomaterialia