Multivalent glycoconjugates as anti-pathogenic agents

Sequence-Defined Glycopolymer Segments Presenting Mannose: Synthesis and Lectin Binding Affinity

(2012) Daniela Ponader et al.   BIOMACROMOLECULES

Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology

(2012) Martin J. Weissenborn et al.   CHEMICAL COMMUNICATIONS

Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA

(2012) Francesca Pertici et al.   CHEMICAL COMMUNICATIONS

A Bacterial Lipooligosaccharide that Naturally Mimics the Epitope of the HIV-Neutralizing Antibody 2G12 as a Template for Vaccine Design

(2012) Brenda E. Clark et al.   CHEMISTRY & BIOLOGY

Multivalent Gold Glycoclusters: High Affinity Molecular Recognition by Bacterial Lectin PA-IL

(2012) Michael Reynolds et al.   CHEMISTRY-A EUROPEAN JOURNAL

Saccharide-Modified Nanodiamond Conjugates for the Efficient Detection and Removal of Pathogenic Bacteria

(2012) Mirja Hartmann et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rational Design and Synthesis of Optimized Glycoclusters for Multivalent Lectin-Carbohydrate Interactions: Influence of the Linker Arm

(2012) Samy Cecioni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inhalation with Fucose and Galactose for Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients

(2012) Hans-Peter Hauber et al.   International Journal of Medical Sciences

Gold nanoparticles as carriers for a syntheticStreptococcus pneumoniaetype 14 conjugate vaccine

(2012) Dodi Safari et al.   Nanomedicine

Bi- to tetravalent glycoclusters: synthesis, structure–activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity

(2012) Guan-Nan Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A glycomimetic compound inhibits DC-SIGN-mediated HIV infection in cellular and cervical explant models

(2011) Angela Berzi et al.   AIDS

A Glycopeptide Dendrimer Inhibitor of the Galactose-Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms

(2011) Rameshwar U. Kadam et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glycan Microarrays for Decoding the Glycome

(2011) Cory D. Rillahan et al.   Annual Review of Biochemistry

Pseudosaccharide Functionalized Dendrimers as Potent Inhibitors of DC-SIGN Dependent Ebola Pseudotyped Viral Infection

(2011) Joanna Luczkowiak et al.   BIOCONJUGATE CHEMISTRY

Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons

(2011) Sabine André et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists

(2011) Francesco Peri et al.   BIOTECHNOLOGY ADVANCES

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes

(2011) Sabine André et al.   CHEMICAL COMMUNICATIONS

Multivalent glyconanoparticles with enhanced affinity to the anti-viral lectin Cyanovirin-N

(2011) Xin Wang et al.   CHEMICAL COMMUNICATIONS

AFM investigation of Pseudomonas aeruginosa lectin LecA (PA-IL) filaments induced by multivalent glycoclusters

(2011) Delphine Sicard et al.   CHEMICAL COMMUNICATIONS

A Solution NMR Study of the Interactions of Oligomannosides and the Anti-HIV-1 2G12 Antibody Reveals Distinct Binding Modes for Branched Ligands*

(2011) Pedro M. Enríquez-Navas et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Inhibition of Liposaccharide Heptosyltransferase WaaC with Multivalent Glycosylated Fullerenes: A New Mode of Glycosyltransferase Inhibition

(2011) Maxime Durka et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Dodecavalent Fullerene-Based Glycoclusters and Evaluation of Their Binding Properties towards a Bacterial Lectin

(2011) Samy Cecioni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Combining Glycomimetic and Multivalent Strategies toward Designing Potent Bacterial Lectin Inhibitors

(2011) Yoann M. Chabre et al.   CHEMISTRY-A EUROPEAN JOURNAL

Clustering of Escherichia coli Type-1 Fimbrial Adhesins by Using Multimeric Heptyl α-D-Mannoside Probes with a Carbohydrate Core

(2011) Mehdi Almant et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selectivity among Two Lectins: Probing the Effect of Topology, Multivalency and Flexibility of “Clicked” Multivalent Glycoclusters

(2011) Samy Cecioni et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Synthetic Lipid A Mimetic Modulates Human TLR4 Activity

(2011) Matteo Piazza et al.   ChemMedChem

Inhibition of the bacterial lectins of Pseudomonas aeruginosa with monosaccharides and peptides

(2011) H. Gustke et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

The Bacterial Lectin FimH, a Target for Drug Discovery - Carbohydrate Inhibitors of Type 1 Fimbriae-Mediated Bacterial Adhesion

(2011) Mirja Hartmann et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Recombinant protein meningococcal serogroup B vaccine combined with outer membrane vesicles

(2011) Xilian Bai et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Detection of antibodies in neuropathy patients by synthetic GM1 mimics

(2011) A. V. Pukin et al.   GLYCOBIOLOGY

Glycosylation Is Required for Outer Membrane Localization of the Lectin LecB in Pseudomonas aeruginosa

(2011) K.-M. Bartels et al.   JOURNAL OF BACTERIOLOGY

Identification of a Novel Streptococcal Adhesin P (SadP) Protein Recognizing Galactosyl-α1–4-galactose-containing Glycoconjugates

(2011) Annika Kouki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gold Nanoparticles Coated with Oligomannosides of HIV-1 Glycoprotein gp120 Mimic the Carbohydrate Epitope of Antibody 2G12

(2011) Marco Marradi et al.   JOURNAL OF MOLECULAR BIOLOGY

Probing Carbohydrate-Lectin Recognition in Heterogeneous Environments with Monodisperse Cyclodextrin-Based Glycoclusters

(2011) Marta Gómez-García et al.   JOURNAL OF ORGANIC CHEMISTRY

Exploiting Dendrimer Multivalency To Combat Emerging and Re-Emerging Infectious Diseases

(2011) Meredith A. Mintzer et al.   MOLECULAR PHARMACEUTICS

CuAAC synthesis of resorcin[4]arene-based glycoclusters as multivalent ligands of lectins

(2011) Zahid H. Soomro et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Peptide and glycopeptide dendrimer apple trees as enzyme models and for biomedical applications

(2011) Jean-Louis Reymond et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

(2011) R. Pejchal et al.   SCIENCE

Multivalent calixarene-based C-fucosyl derivative: a new Pseudomonas aeruginosa biofilm inhibitor

(2011) Grazia M.L. Consoli et al.   TETRAHEDRON LETTERS

From lectin structure to functional glycomics: principles of the sugar code

(2011) Hans-Joachim Gabius et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids

(2011) Emma M. V. Johansson et al.   MedChemComm

Inhibition of DC-SIGN-Mediated HIV Infection by a Linear Trimannoside Mimic in a Tetravalent Presentation

(2010) Sara Sattin et al.   ACS Chemical Biology

Uniform Lipopolysaccharide (LPS)-Loaded Magnetic Nanoparticles for the Investigation of LPS-TLR4 Signaling

(2010) Matteo Piazza et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Carbohydrate-Functionalized Quantum Dots in Microreactors

(2010) Raghavendra Kikkeri et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploring the LPS/TLR4 signal pathway with small molecules

(2010) Francesco Peri et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Characterization of multivalent lactose quantum dots and its application in carbohydrate–protein interactions study and cell imaging

(2010) Yang Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Monovalent and bivalent N-fucosyl amides as high affinity ligands for Pseudomonas aeruginosa PA-IIL lectin

(2010) Manuel Andreini et al.   CARBOHYDRATE RESEARCH

Cell surface display of chimeric glycoproteins via the S-layer of Paenibacillus alvei

(2010) Kristof Zarschler et al.   CARBOHYDRATE RESEARCH

Enhancement of Plant and Bacterial Lectin Binding Affinities by Three-Dimensional Organized Cluster Glycosides Constructed on Helical Poly(phenylacetylene) Backbones

(2010) Issei Otsuka  et al.   CHEMBIOCHEM

Fullerene sugar balls

(2010) Jean-François Nierengarten et al.   CHEMICAL COMMUNICATIONS

The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH—towards novel bacterial antiadhesives

(2010) Maxime Durka et al.   CHEMICAL COMMUNICATIONS

Calixarene and Calixresorcarene Glycosides: Their Synthesis and Biological Applications

(2010) Alessandro Dondoni et al.   CHEMICAL REVIEWS

Defining Criteria for Oligomannose Immunogens for HIV Using Icosahedral Virus Capsid Scaffolds

(2010) Rena D. Astronomo et al.   CHEMISTRY & BIOLOGY

[60]Fullerene as Multivalent Scaffold: Efficient Molecular Recognition of Globular Glycofullerenes by Concanavalin A

(2010) Macarena Sánchez-Navarro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Thermodynamics and chemical characterization of protein–carbohydrate interactions: The multivalency issue

(2010) Michael Reynolds et al.   COMPTES RENDUS CHIMIE

Targeting DC-SIGN with carbohydrate multivalent systems

(2010) M. Sanchez-Navarro et al.   DRUG NEWS & PERSPECTIVES

Analogies and homologies in lipopolysaccharide and glycoprotein biosynthesis in bacteria

(2010) I. Hug et al.   GLYCOBIOLOGY

Preparation, characterization and immunogenicity of HIV-1 related high-mannose oligosaccharides-CRM197 glycoconjugates

(2010) Anna Kabanova et al.   GLYCOCONJUGATE JOURNAL

Hepatocyte Targeting and Intracellular Copper Chelation by a Thiol-Containing Glycocyclopeptide

(2010) Anaïs M. Pujol et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

Detection of pathogenic Streptococcus suis bacteria using magnetic glycoparticles

(2010) Núria Parera Pera et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands

(2010) David Deniaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Characterization of liposomes formed by lipopolysaccharides from Burkholderia cenocepacia, Burkholderia multivorans and Agrobacterium tumefaciens: from the molecular structure to the aggregate architecture

(2010) Gerardino D'Errico et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Thermodynamics of Multivalent Carbohydrate−Lectin Cross-Linking Interactions: Importance of Entropy in the Bind and Jump Mechanism

(2009) Tarun K. Dam et al.   BIOCHEMISTRY

Evidence of a Specific Interaction between New Synthetic Antisepsis Agents and CD14

(2009) Matteo Piazza et al.   BIOCHEMISTRY

Polyester Nanoparticles Presenting Mannose Residues: Toward the Development of New Vaccine Delivery Systems Combining Biodegradability and Targeting Properties

(2009) Jutta Rieger et al.   BIOMACROMOLECULES

Multivalent Manno-Glyconanoparticles Inhibit DC-SIGN-Mediated HIV-1 Trans-Infection of Human T Cells

(2009) Olga Martínez-Ávila et al.   CHEMBIOCHEM

Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins

(2009) Richard J. Payne et al.   CHEMICAL COMMUNICATIONS

A kit for the investigation of live Escherichia colicell adhesion to glycosylated surfaces

(2009) Mirja Hartmann et al.   CHEMICAL COMMUNICATIONS

GoldManno-Glyconanoparticles: Multivalent Systems to Block HIV-1 gp120 Binding to the Lectin DC-SIGN

(2009) Olga Martínez-Ávila et al.   CHEMISTRY-A EUROPEAN JOURNAL

Achieving High Affinity towards a Bacterial Lectin through Multivalent Topological Isomers of Calix[4]arene Glycoconjugates

(2009) Samy Cecioni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Glycopeptide Dendrimers with High Affinity for the Fucose-Binding Lectin LecB fromPseudomonas aeruginosa

(2009) Elena Kolomiets et al.   ChemMedChem

Carbohydrate arrays: recent developments in fabrication and detection methods with applications

(2009) Eun-Ho Song et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Glycan arrays: recent advances and future challenges

(2009) Oyindasola Oyelaran et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin

(2009) Emilie Lameignere et al.   GLYCOBIOLOGY

Role of LecA and LecB Lectins in Pseudomonas aeruginosa-Induced Lung Injury and Effect of Carbohydrate Ligands

(2009) C. Chemani et al.   INFECTION AND IMMUNITY

Glycolipids and Benzylammonium Lipids as Novel Antisepsis Agents: Synthesis and Biological Characterization

(2009) Matteo Piazza et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Bivalent Lactosides Based on Terephthalamide,N,N′-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins

(2009) Rosaria Leyden et al.   JOURNAL OF ORGANIC CHEMISTRY

Combinatorial libraries of peptide dendrimers: design, synthesis, on-bead high-throughput screening, bead decoding and characterization

(2009) Noélie Maillard et al.   Nature Protocols

Roles of galectins in infection

(2009) Gerardo R. Vasta   NATURE REVIEWS MICROBIOLOGY

Maximising multivalency effects in protein–carbohydrate interactions

(2009) Roland J. Pieters   ORGANIC & BIOMOLECULAR CHEMISTRY

Mesoscopic and microstructural characterization of liposomes formed by the lipooligosaccharide from Salmonella minnesota strain 595 (Re mutant)

(2009) Gerardino D’Errico et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Screening of binding activity of Streptococcus pneumoniae, Streptococcus agalactiae and Streptococcus suis to berries and juices

(2009) Marko Toivanen et al.   PHYTOTHERAPY RESEARCH

Structural basis for mannose recognition by a lectin from opportunistic bacteriaBurkholderia cenocepacia

(2008) Emilie Lameignere et al.   BIOCHEMICAL JOURNAL

GM3, GM2 and GM1 mimics designed for biosensing: chemoenzymatic synthesis, target affinities and 900MHz NMR analysis

(2008) Aliaksei V. Pukin et al.   CARBOHYDRATE RESEARCH

The Influence of Ligand Valency on Aggregation Mechanisms for Inhibiting Bacterial Toxins

(2008) Cristina Sisu et al.   CHEMBIOCHEM

Carbohydrate arrays as tools for research and diagnostics

(2008) Tim Horlacher et al.   CHEMICAL SOCIETY REVIEWS

Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB

(2008) Emma M.V. Johansson et al.   CHEMISTRY & BIOLOGY

Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins

(2008) Anne Imberty et al.   CHEMISTRY-A EUROPEAN JOURNAL

Interfering with the Sugar Code: Design and Synthesis of Oligosaccharide Mimics

(2008) Anna Bernardi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Microbial recognition of human cell surface glycoconjugates

(2008) Anne Imberty et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Glycopeptide Dendrimers for Biomedical Applications

(2008) Tamis Darbre et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A Glycoconjugate Antigen Based on the Recognition Motif of a Broadly Neutralizing Human Immunodeficiency Virus Antibody, 2G12, Is Immunogenic but Elicits Antibodies Unable To Bind to the Self Glycans of gp120

(2008) R. D. Astronomo et al.   JOURNAL OF VIROLOGY

Synthesis of multivalent Streptococcus suis adhesion inhibitors by enzymatic cleavage of polygalacturonic acid and ‘click’ conjugation

(2008) Hilbert M. Branderhorst et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions

(2008) J. G. Joyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant Glycans on an S-Layer Self-Assembly Protein: A New Dimension for Nanopatterned Biomaterials

(2008) Kerstin Steiner et al.   Small