标题
The therapeutic landscape of HIV-1 via genome editing
作者
关键词
-
出版物
AIDS Research and Therapy
Volume 14, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-07-14
DOI
10.1186/s12981-017-0157-8
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cell-penetrating peptides recruit type A scavenger receptors to the plasma membrane for cellular delivery of nucleic acids
- (2017) Carmen Juks et al. FASEB JOURNAL
- TALEN-Mediated Knockout of CCR5 Confers Protection Against Infection of Human Immunodeficiency Virus
- (2017) Bingjie Shi et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides
- (2017) Shama Dissanayake et al. JOURNAL OF CONTROLLED RELEASE
- A Lipopeptide HIV-1/2 Fusion Inhibitor with Highly Potent In Vitro , Ex Vivo , and In Vivo Antiviral Activity
- (2017) Huihui Chong et al. JOURNAL OF VIROLOGY
- In vitro and in vivo delivery of therapeutic proteins using cell penetrating peptides
- (2017) Azam Bolhassani et al. PEPTIDES
- Cell-Penetrating Peptides: From Basic Research to Clinics
- (2017) Giulia Guidotti et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy
- (2016) Harshana S. De Silva Feelixge et al. ANTIVIRAL RESEARCH
- Targeting the rhesus macaque TRIM5α gene to enhance the susceptibility of CD4+ T cells to HIV-1 infection
- (2016) Xiaoli Wang et al. ARCHIVES OF VIROLOGY
- Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA
- (2016) Takashi Yamano et al. CELL
- Cell-penetrating peptides with intracellular organelle targeting
- (2016) Carmine Pasquale Cerrato et al. Expert Opinion on Drug Delivery
- Lentivirus pre-packed with Cas9 protein for safer gene editing
- (2016) J G Choi et al. GENE THERAPY
- Genome editing and the next generation of antiviral therapy
- (2016) Daniel Stone et al. HUMAN GENETICS
- RNA interference in mosquito: understanding immune responses, double-stranded RNA delivery systems and potential applications in vector control
- (2016) A. Balakrishna Pillai et al. INSECT MOLECULAR BIOLOGY
- Advancements in nano-enabled therapeutics for neuroHIV management
- (2016) Ajeet Kaushik et al. International Journal of Nanomedicine
- Towards HIV-1 remission: potential roles for broadly neutralizing antibodies
- (2016) Ariel Halper-Stromberg et al. JOURNAL OF CLINICAL INVESTIGATION
- Molecular mechanisms of HIV latency
- (2016) Daniele C. Cary et al. JOURNAL OF CLINICAL INVESTIGATION
- Pulmonary administration of small interfering RNA: The route to go?
- (2016) M.J.R. Ruigrok et al. JOURNAL OF CONTROLLED RELEASE
- CRISPR-Cas9 Can Inhibit HIV-1 Replication but NHEJ Repair Facilitates Virus Escape
- (2016) Gang Wang et al. MOLECULAR THERAPY
- A One-Step System for Convenient and Flexible Assembly of Transcription Activator-Like Effector Nucleases (TALENs)
- (2016) Jinlong Zhao et al. MOLECULES AND CELLS
- Replications, ridicule and a recluse: the controversy over NgAgo gene-editing intensifies
- (2016) David Cyranoski NATURE
- DNA-guided genome editing using the Natronobacterium gregoryi Argonaute
- (2016) Feng Gao et al. NATURE BIOTECHNOLOGY
- International AIDS Society global scientific strategy: towards an HIV cure 2016
- (2016) Steven G Deeks et al. NATURE MEDICINE
- The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model
- (2016) Woldeab B. Haile et al. NEUROBIOLOGY OF DISEASE
- Transcriptional gene silencing in humans
- (2016) Marc S. Weinberg et al. NUCLEIC ACIDS RESEARCH
- CRISPR/Cas9: a double-edged sword when used to combat HIV infection
- (2016) Chen Liang et al. Retrovirology
- CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape
- (2016) Zhen Wang et al. Cell Reports
- Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing
- (2016) Rafal Kaminski et al. Scientific Reports
- Delivery of therapeutic oligonucleotides with cell penetrating peptides
- (2015) Prisca Boisguérin et al. ADVANCED DRUG DELIVERY REVIEWS
- Procyanidin trimer C1 derived from Theobroma cacao reactivates latent human immunodeficiency virus type 1 provirus
- (2015) Takanori Hori et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- Targeted genome editing in primate embryos
- (2015) Xiangyu Guo et al. CELL RESEARCH
- Inhibition of nonhomologous end joining to increase the specificity of CRISPR/Cas9 genome editing
- (2015) Supriya V. Vartak et al. FEBS Journal
- Preclinical Assessment of Mutant Human TRIM5α as an Anti-HIV-1 Transgene
- (2015) Ulrike Jung et al. HUMAN GENE THERAPY
- Optimization of methods for the genetic modification of human T cells
- (2015) Mahmood Y Bilal et al. IMMUNOLOGY AND CELL BIOLOGY
- Expanding the Biologist’s Toolkit with CRISPR-Cas9
- (2015) Samuel H. Sternberg et al. MOLECULAR CELL
- Nanotechnology Approaches for the Delivery of Exogenous siRNA for HIV Therapy
- (2015) Simeon K. Adesina et al. MOLECULAR PHARMACEUTICS
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities
- (2015) Benjamin P. Kleinstiver et al. NATURE
- HIV reservoirs as obstacles and opportunities for an HIV cure
- (2015) Tae-Wook Chun et al. NATURE IMMUNOLOGY
- mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5
- (2015) U. Mock et al. NUCLEIC ACIDS RESEARCH
- Damaging the Integrated HIV Proviral DNA with TALENs
- (2015) Christy L. Strong et al. PLoS One
- Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis inAedes aegypti
- (2015) Sanjay Basu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Application of gene-editing technologies to HIV-1
- (2015) Mary Jane Drake et al. Current Opinion in HIV and AIDS
- Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing
- (2015) Francis Robert et al. Genome Medicine
- RNA interference approaches for treatment of HIV-1 infection
- (2015) Maggie L Bobbin et al. Genome Medicine
- An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression
- (2015) Gilles Darcis et al. PLoS Pathogens
- The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo
- (2015) Ole S. Søgaard et al. PLoS Pathogens
- Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study
- (2015) Julian H Elliott et al. Lancet HIV
- Efficient genome editing in hematopoietic stem cells with helper-dependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation
- (2015) Kamola Saydaminova et al. Molecular Therapy-Methods & Clinical Development
- A Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb’s Release from 7SK snRNP
- (2015) Cong Wang et al. PLoS One
- Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ–NF-κB signaling
- (2014) Guochun Jiang et al. AIDS
- Ruxolitinib and Tofacitinib Are Potent and Selective Inhibitors of HIV-1 Replication and Virus ReactivationIn Vitro
- (2014) Christina Gavegnano et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Recognition of the HIV Capsid by the TRIM5α Restriction Factor Is Mediated by a Subset of Pre-Existing Conformations of the TRIM5α SPRY Domain
- (2014) Dmytro B. Kovalskyy et al. BIOCHEMISTRY
- Optimizing nanomedicine pharmacokinetics using physiologically based pharmacokinetics modelling
- (2014) Darren Michael Moss et al. BRITISH JOURNAL OF PHARMACOLOGY
- Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
- (2014) Yuyu Niu et al. CELL
- TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys
- (2014) Hailiang Liu et al. Cell Stem Cell
- Development of HIV Reservoir Targeted Long Acting Nanoformulated Antiretroviral Therapies
- (2014) Benson Edagwa et al. CURRENT MEDICINAL CHEMISTRY
- TALEN Knockout of the PSIP1 Gene in Human Cells: Analyses of HIV-1 Replication and Allosteric Integrase Inhibitor Mechanism
- (2014) H. J. Fadel et al. JOURNAL OF VIROLOGY
- HIV infection: epidemiology, pathogenesis, treatment, and prevention
- (2014) Gary Maartens et al. LANCET
- Stabilized Human TRIM5α Protects Human T Cells From HIV-1 Infection
- (2014) Max W Richardson et al. MOLECULAR THERAPY
- Computer-Guided Design, Synthesis, and Protein Kinase C Affinity of a New Salicylate-Based Class of Bryostatin Analogs
- (2014) Paul A. Wender et al. ORGANIC LETTERS
- Dual Role of Novel Ingenol Derivatives from Euphorbia tirucalli in HIV Replication: Inhibition of De Novo Infection and Activation of Viral LTR
- (2014) Celina M. Abreu et al. PLoS One
- CCR5 Gene Disruption via Lentiviral Vectors Expressing Cas9 and Single Guided RNA Renders Cells Resistant to HIV-1 Infection
- (2014) Weiming Wang et al. PLoS One
- Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir
- (2014) T.-W. Chun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The new frontier of genome engineering with CRISPR-Cas9
- (2014) J. A. Doudna et al. SCIENCE
- Reactivation of latent HIV-1 by new semi-synthetic ingenol esters
- (2014) Diego Pandeló José et al. VIROLOGY
- Novel lentiviral vectors with mutated reverse transcriptase for mRNA delivery of TALE nucleases
- (2014) Ulrike Mock et al. Scientific Reports
- A Conserved Target Site in HIV-1 Gag RNA is Accessible to Inhibition by Both an HDV Ribozyme and a Short Hairpin RNA
- (2014) Robert J Scarborough et al. Molecular Therapy-Nucleic Acids
- Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial
- (2014) Thomas A Rasmussen et al. Lancet HIV
- Chemotherapeutic Compounds Targeting the DNA Double-Strand Break Repair Pathways: The Good, the Bad, and the Promising
- (2014) Christian Jekimovs et al. Frontiers in Oncology
- Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure
- (2013) Ya-Chi Ho et al. CELL
- BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism
- (2013) Daniela Boehm et al. CELL CYCLE
- Reduction in Early Mortality on Antiretroviral Therapy for Adults in Rural South Africa Since Change in CD4+ Cell Count Eligibility Criteria
- (2013) Richard J. Lessells et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA
- (2013) A. Singh et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Capsid-binding retrovirus restriction factors: discovery, restriction specificity and implications for the development of novel therapeutics
- (2013) M. Sanz-Ramos et al. JOURNAL OF GENERAL VIROLOGY
- The end of AIDS: HIV infection as a chronic disease
- (2013) Steven G Deeks et al. LANCET
- Genomic Editing of the HIV-1 Coreceptor CCR5 in Adult Hematopoietic Stem and Progenitor Cells Using Zinc Finger Nucleases
- (2013) Lijing Li et al. MOLECULAR THERAPY
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Development of Hematopoietic Stem Cell Based Gene Therapy for HIV-1 Infection: Considerations for Proof of Concept Studies and Translation to Standard Medical Practice
- (2013) David DiGiusto et al. Viruses-Basel
- Newer Gene Editing Technologies toward HIV Gene Therapy
- (2013) N. Manjunath et al. Viruses-Basel
- An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients
- (2013) Celsa A. Spina et al. PLoS Pathogens
- RNA-programmed genome editing in human cells
- (2013) Martin Jinek et al. eLife
- Developing microRNA screening as a functional genomics tool for disease research
- (2013) Derek Lemons et al. Frontiers in Physiology
- RNA Interference for Viral Infections
- (2012) Stephen J. Blake et al. CURRENT DRUG TARGETS
- Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation
- (2012) Liang Shan et al. IMMUNITY
- Bromodomain and Extra-terminal (BET) Bromodomain Inhibition Activate Transcription via Transient Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein
- (2012) Koen Bartholomeeusen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of Histone Deacetylase Inhibitors on HIV Production in Latently Infected, Resting CD4+ T Cells From Infected Individuals Receiving Effective Antiretroviral Therapy
- (2012) J. Blazkova et al. JOURNAL OF INFECTIOUS DISEASES
- Generation of an HIV-1-Resistant Immune System with CD34+ Hematopoietic Stem Cells Transduced with a Triple-Combination Anti-HIV Lentiviral Vector
- (2012) J. E. Walker et al. JOURNAL OF VIROLOGY
- Functional In Vivo Delivery of Multiplexed Anti-HIV-1 siRNAs via a Chemically Synthesized Aptamer With a Sticky Bridge
- (2012) Jiehua Zhou et al. MOLECULAR THERAPY
- Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
- (2012) N. M. Archin et al. NATURE
- Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro
- (2012) Brian A. DeChristopher et al. Nature Chemistry
- Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
- (2012) Thomas Gaj et al. NATURE METHODS
- TALENs: a widely applicable technology for targeted genome editing
- (2012) J. Keith Joung et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells
- (2012) Maarten Holkers et al. NUCLEIC ACIDS RESEARCH
- The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
- (2012) Frauke Christ et al. VIROLOGY
- Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells
- (2012) Victoria A Green et al. Virology Journal
- Localized, Targeted, and Sustained siRNA Delivery
- (2011) Melissa D. Krebs et al. CHEMISTRY-A EUROPEAN JOURNAL
- Current progress in the development of RNAi-based therapeutics for HIV-1
- (2011) J Zhou et al. GENE THERAPY
- Systemic Administration of Combinatorial dsiRNAs via Nanoparticles Efficiently Suppresses HIV-1 Infection in Humanized Mice
- (2011) Jiehua Zhou et al. MOLECULAR THERAPY
- Genetic engineering of human pluripotent cells using TALE nucleases
- (2011) Dirk Hockemeyer et al. NATURE BIOTECHNOLOGY
- Gene silencing by microRNAs: contributions of translational repression and mRNA decay
- (2011) Eric Huntzinger et al. NATURE REVIEWS GENETICS
- Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting
- (2011) Tomas Cermak et al. NUCLEIC ACIDS RESEARCH
- Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific
- (2011) Kazuo Suzuki et al. RNA Biology
- The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation
- (2010) Aaron Klug Annual Review of Biochemistry
- Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors
- (2010) Julia J.M. Eekels et al. ANTIVIRAL RESEARCH
- Bryostatin-1 Synergizes with Histone Deacetylase Inhibitors to Reactivate HIV-1 from Latency
- (2010) Moises Perez et al. CURRENT HIV RESEARCH
- TAL effectors: finding plant genes for disease and defense
- (2010) Adam J Bogdanove et al. CURRENT OPINION IN PLANT BIOLOGY
- RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?
- (2010) Sandesh Subramanya et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Antiretroviral therapy and management of HIV infection
- (2010) Paul A Volberding et al. LANCET
- Enhanced Induction of HIV-specific Cytotoxic T Lymphocytes by Dendritic Cell-targeted Delivery of SOCS-1 siRNA
- (2010) Sandesh Subramanya et al. MOLECULAR THERAPY
- A TALE nuclease architecture for efficient genome editing
- (2010) Jeffrey C Miller et al. NATURE BIOTECHNOLOGY
- Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging
- (2010) Sonu Bhaskar et al. Particle and Fibre Toxicology
- Posttranscriptional gene silencing in nuclei
- (2010) P. Hoffer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms of HIV Latency: an Emerging Picture of Complexity
- (2010) David M. Margolis Current HIV/AIDS Reports
- Non-AIDS-defining deaths and immunodeficiency in the era of combination antiretroviral therapy
- (2009) Benoît Marin et al. AIDS
- Epigenetics: heterochromatin meets RNAi
- (2009) Ingela Djupedal et al. CELL RESEARCH
- Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components
- (2009) Martha R. Neagu et al. JOURNAL OF CLINICAL INVESTIGATION
- HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome
- (2009) Lyubov Zaitseva et al. Retrovirology
- Tightly regulated gene expression in human hematopoietic stem cells after transduction with helper-dependent Ad5/35 vectors
- (2008) Hongje Wang et al. EXPERIMENTAL HEMATOLOGY
- Knockdown of Cellular RNA Helicase DDX3 by Short Hairpin RNAs Suppresses HIV-1 Viral Replication Without Inducing Apoptosis
- (2008) Musarat Ishaq et al. MOLECULAR BIOTECHNOLOGY
- Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
- (2008) Elena E Perez et al. NATURE BIOTECHNOLOGY
- Cyclin T1-Dependent Genes in Activated CD4+ T and Macrophage Cell Lines Appear Enriched in HIV-1 Co-Factors
- (2008) Wendong Yu et al. PLoS One
- CRISPR — a widespread system that provides acquired resistance against phages in bacteria and archaea
- (2007) Rotem Sorek et al. NATURE REVIEWS MICROBIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started