Capsid-binding retrovirus restriction factors: discovery, restriction specificity and implications for the development of novel therapeutics

Antiviral strategies combining antiretroviral drugs with RNAi-mediated attack on HIV-1 and cellular co-factors

(2013) Fatima Boutimah et al.   ANTIVIRAL RESEARCH

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors

(2013) Gijs A. Versteeg et al.   IMMUNITY

Virus-Specific Effects of TRIM5 rh RING Domain Functions on Restriction of Retroviruses

(2013) X. Li et al.   JOURNAL OF VIROLOGY

A Comparison of Murine Leukemia Viruses That Escape from Human and Rhesus Macaque TRIM5 s

(2013) S. Ohkura et al.   JOURNAL OF VIROLOGY

Generation of an HIV Resistant T-cell Line by Targeted “Stacking” of Restriction Factors

(2013) Richard A Voit et al.   MOLECULAR THERAPY

Genomic Editing of the HIV-1 Coreceptor CCR5 in Adult Hematopoietic Stem and Progenitor Cells Using Zinc Finger Nucleases

(2013) Lijing Li et al.   MOLECULAR THERAPY

Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics

(2013) Gongpu Zhao et al.   NATURE

Birth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomes

(2013) R. Malfavon-Borja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV Restriction Factors and Mechanisms of Evasion

(2013) M. H. Malim et al.   Cold Spring Harbor Perspectives in Medicine

Extreme Genetic Fragility of the HIV-1 Capsid

(2013) Suzannah J. Rihn et al.   PLoS Pathogens

Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection

(2013) Sebla B. Kutluay et al.   PLoS Pathogens

Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α Specificity

(2013) Kevin R. McCarthy et al.   PLoS Pathogens

A Unique Spumavirus Gag N-terminal Domain with Functional Properties of Orthoretroviral Matrix and Capsid

(2013) David C. Goldstone et al.   PLoS Pathogens

Unraveling the divergent results of pre-exposure prophylaxis trials for HIV prevention

(2012) Ariane van der Straten et al.   AIDS

Lentiviral Gene Therapy Against Human Immunodeficiency Virus Type 1, Using a Novel Human TRIM21-Cyclophilin A Restriction Factor

(2012) Emma Chan et al.   HUMAN GENE THERAPY

The Restriction Factors of Human Immunodeficiency Virus

(2012) Reuben S. Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse HIV viruses are targeted by a conformationally dynamic antiviral

(2012) Matthew E C Caines et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Preexposure Prophylaxis for HIV — Where Do We Go from Here?

(2012) Myron S. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural insight into HIV-1 capsid recognition by rhesus TRIM5 

(2012) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the rhesus monkey TRIM5  PRYSPRY domain, the HIV capsid recognition module

(2012) N. Biris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions

(2012) Zana Lukic et al.   Retrovirology

Multiple roles of the capsid protein in the early steps of HIV-1 infection

(2012) Ariberto Fassati   VIRUS RESEARCH

Unique Spectrum of Activity of Prosimian TRIM5  against Exogenous and Endogenous Retroviruses

(2011) N. Rahm et al.   JOURNAL OF VIROLOGY

The TRIM5  Genotype of Rhesus Macaques Affects Acquisition of Simian Immunodeficiency Virus SIVsmE660 Infection after Repeated Limiting-Dose Intrarectal Challenge

(2011) M. R. Reynolds et al.   JOURNAL OF VIROLOGY

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

New Insights into HIV Assembly and Trafficking

(2011) Muthukumar Balasubramaniam et al.   PHYSIOLOGY

Origin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish

(2011) Pierre Boudinot et al.   PLoS One

Ordered assembly of murine leukemia virus capsid protein on lipid nanotubes directs specific binding by the restriction factor, Fv1

(2011) L. Hilditch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-stepping through time: mammals and viruses

(2011) Nicholas R. Meyerson et al.   TRENDS IN MICROBIOLOGY

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

(2011) Torsten Schaller et al.   PLoS Pathogens

Rhesus TRIM5α Disrupts the HIV-1 Capsid at the Inter­Hexamer Interfaces

(2011) Gongpu Zhao et al.   PLoS Pathogens

Novel Escape Mutants Suggest an Extensive TRIM5α Binding Site Spanning the Entire Outer Surface of the Murine Leukemia Virus Capsid Protein

(2011) Sadayuki Ohkura et al.   PLoS Pathogens

Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation

(2010) K. Allers et al.   BLOOD

Flexible Use of Nuclear Import Pathways by HIV-1

(2010) KyeongEun Lee et al.   Cell Host & Microbe

Structural and Functional Analysis of Prehistoric Lentiviruses Uncovers an Ancient Molecular Interface

(2010) David C. Goldstone et al.   Cell Host & Microbe

TRIM5  Disrupts the Structure of Assembled HIV-1 Capsid Complexes In Vitro

(2010) L. R. Black et al.   JOURNAL OF VIROLOGY

Hexagonal assembly of a restricting TRIM5  protein

(2010) B. K. Ganser-Pornillos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single amino acid substitution of the human immunodeficiency virus type 1 capsid protein affects viral sensitivity to TRIM5α

(2010) Ayumu Kuroishi et al.   Retrovirology

Multiple sites in the N-terminal half of simian immunodeficiency virus capsid protein contribute to evasion from rhesus monkey TRIM5α-mediated restriction

(2010) Ken Kono et al.   Retrovirology

Identification of residues within the L2 region of rhesus TRIM5α that are required for retroviral restriction and cytoplasmic body localization

(2010) Jaya Sastri et al.   VIROLOGY

TRIM5 Suppresses Cross-Species Transmission of a Primate Immunodeficiency Virus and Selects for Emergence of Resistant Variants in the New Species

(2010) Andrea Kirmaier et al.   PLOS BIOLOGY

Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity

(2010) Laura M. J. Ylinen et al.   PLoS Pathogens

TRIM5α Modulates Immunodeficiency Virus Control in Rhesus Monkeys

(2010) So-Yon Lim et al.   PLoS Pathogens

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

(2010) Wade S. Blair et al.   PLoS Pathogens

Molecular evolution of the antiretroviral TRIM5 gene

(2009) Welkin E. Johnson et al.   IMMUNOGENETICS

Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components

(2009) Martha R. Neagu et al.   JOURNAL OF CLINICAL INVESTIGATION

Human TRIM5α Expression Levels and Reduced Susceptibility to HIV‐1 Infection

(2009) Shamman Sewram et al.   JOURNAL OF INFECTIOUS DISEASES

A B-Box 2 Surface Patch Important for TRIM5  Self-Association, Capsid Binding Avidity, and Retrovirus Restriction

(2009) F. Diaz-Griffero et al.   JOURNAL OF VIROLOGY

Visualization of a proteasome-independent intermediate during restriction of HIV-1 by rhesus TRIM5α

(2008) Edward M. Campbell et al.   JOURNAL OF CELL BIOLOGY

Structure of B-MLV Capsid Amino-terminal Domain Reveals Key Features of Viral Tropism, Gag Assembly and Core Formation

(2008) Gulnahar B. Mortuza et al.   JOURNAL OF MOLECULAR BIOLOGY

The TRIM5  B-Box 2 Domain Promotes Cooperative Binding to the Retroviral Capsid by Mediating Higher-Order Self-Association

(2008) X. Li et al.   JOURNAL OF VIROLOGY

Restriction of Foamy Viruses by Primate Trim5 

(2008) M. W. Yap et al.   JOURNAL OF VIROLOGY

Rhesus Macaque TRIM5 Alleles Have Divergent Antiretroviral Specificities

(2008) S. J. Wilson et al.   JOURNAL OF VIROLOGY

Biochemical Characterization of a Recombinant TRIM5  Protein That Restricts Human Immunodeficiency Virus Type 1 Replication

(2008) C. R. Langelier et al.   JOURNAL OF VIROLOGY

The Effect of Trim5 Polymorphisms on the Clinical Course of HIV-1 Infection

(2008) Daniëlle van Manen et al.   PLoS Pathogens

TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis

(2008) G. Brennan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species

(2008) C. A. Virgen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Independent evolution of an antiviral TRIMCyp in rhesus macaques

(2008) S. J. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for Restriction of Ancient Primate Gammaretroviruses by APOBEC3 but Not TRIM5α Proteins

(2008) David Perez-Caballero et al.   PLoS Pathogens

Proteasomal Degradation of TRIM5α during Retrovirus Restriction

(2008) Christopher James Rold et al.   PLoS Pathogens

Evolution of a TRIM5-CypA Splice Isoform in Old World Monkeys

(2008) Ruchi M. Newman et al.   PLoS Pathogens