CRISPR/Cas9: a double-edged sword when used to combat HIV infection

Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS

(2016) Chaoran Yin et al.   AIDS

Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy

(2016) Harshana S. De Silva Feelixge et al.   ANTIVIRAL RESEARCH

Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA

(2016) Takashi Yamano et al.   CELL

Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9

(2016) Carolin Anders et al.   MOLECULAR CELL

Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9

(2016) Seiichi Hirano et al.   MOLECULAR CELL

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis

(2016) Bo Wang et al.   MOLECULAR THERAPY

Potent and Targeted Activation of Latent HIV-1 Using the CRISPR/dCas9 Activator Complex

(2016) Sheena M Saayman et al.   MOLECULAR THERAPY

CRISPR-mediated Activation of Latent HIV-1 Expression

(2016) Prajit Limsirichai et al.   MOLECULAR THERAPY

Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity

(2016) Janet Karpinski et al.   NATURE BIOTECHNOLOGY

Harnessing the Prokaryotic Adaptive Immune System as a Eukaryotic Antiviral Defense

(2016) Aryn A. Price et al.   TRENDS IN MICROBIOLOGY

Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing

(2016) Rafal Kaminski et al.   Scientific Reports

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

mTORC2 is a tyrosine kinase

(2015) Xuemin Wang et al.   CELL RESEARCH

Inhibition of nonhomologous end joining to increase the specificity of CRISPR/Cas9 genome editing

(2015) Supriya V. Vartak et al.   FEBS Journal

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

(2015) Benjamin P Kleinstiver et al.   NATURE BIOTECHNOLOGY

The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA

(2015) Weijun Zhu et al.   Retrovirology

Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells

(2015) Hsin-Kai Liao et al.   Nature Communications

Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection

(2015) Panpan Hou et al.   Scientific Reports

CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs

(2015) Yonggang Zhang et al.   Scientific Reports

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

(2014) Lin Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

(2013) Hirotaka Ebina et al.   Scientific Reports

Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections

(2012) J. T. Schiffer et al.   JOURNAL OF VIROLOGY