Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity

Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity

(2014) Catherine Chen et al.   MOLECULAR CELL

The Calcineurin Signaling Network Evolves via Conserved Kinase-Phosphatase Modules that Transcend Substrate Identity

(2014) Aaron Goldman et al.   MOLECULAR CELL

Convergent evolution of a fused sexual cycle promotes the haploid lifestyle

(2014) Racquel Kim Sherwood et al.   NATURE

Exploitation of Latent Allostery Enables the Evolution of New Modes of MAP Kinase Regulation

(2013) Scott M. Coyle et al.   CELL

Evolution and functional cross-talk of protein post-translational modifications

(2013) Pedro Beltrao et al.   Molecular Systems Biology

Following Gene Duplication, Paralog Interference Constrains Transcriptional Circuit Evolution

(2013) Christopher R. Baker et al.   SCIENCE

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

(2013) Meera Soundararajan et al.   STRUCTURE

Adaptive Mutations that Prevent Crosstalk Enable the Expansion of Paralogous Signaling Protein Families

(2012) Emily J. Capra et al.   CELL

Rapid Determination of Multiple Linear Kinase Substrate Motifs by Mass Spectrometry

(2012) Arminja N. Kettenbach et al.   CHEMISTRY & BIOLOGY

Reciprocal Phosphorylation of Yeast Glycerol-3-Phosphate Dehydrogenases in Adaptation to Distinct Types of Stress

(2012) Y. J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Evolution of increased complexity in a molecular machine

(2012) Gregory C. Finnigan et al.   NATURE

Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks

(2012) B. A. Joughin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

A Mechanism for the Evolution of Phosphorylation Sites

(2011) Samuel M. Pearlman et al.   CELL

The Ime2 protein kinase family in fungi: more duties than just meiosis

(2011) Stefan Irniger   MOLECULAR MICROBIOLOGY

Phosphorylation network rewiring by gene duplication

(2011) L. Freschi et al.   Molecular Systems Biology

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Evolution of networks and sequences in eukaryotic cell cycle control

(2011) F. R. Cross et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

(2011) J. Alexander et al.   Science Signaling

MSAProbs: multiple sequence alignment based on pair hidden Markov models and partition function posterior probabilities

(2010) Y. Liu et al.   BIOINFORMATICS

Phosphotyrosine Signaling: Evolving a New Cellular Communication System

(2010) Wendell A. Lim et al.   CELL

The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility

(2010) Lillian K. Fritz-Laylin et al.   CELL

Meiotic Regulators Ndt80 and Ime2 Have Different Roles in Saccharomyces and Neurospora

(2010) E. A. Hutchison et al.   GENETICS

Robustness of Ancestral Sequence Reconstruction to Phylogenetic Uncertainty

(2010) Victor Hanson-Smith et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evolution of Characterized Phosphorylation Sites in Budding Yeast

(2010) A. N. Nguyen Ba et al.   MOLECULAR BIOLOGY AND EVOLUTION

Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance

(2010) J. D. Bloom et al.   SCIENCE

Deciphering Protein Kinase Specificity Through Large-Scale Analysis of Yeast Phosphorylation Site Motifs

(2010) J. Mok et al.   Science Signaling

New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0

(2010) Stéphane Guindon et al.   SYSTEMATIC BIOLOGY

Moving from transcriptional to phospho-evolution: generalizing regulatory evolution?

(2010) Alan M. Moses et al.   TRENDS IN GENETICS

The protein kinase ImeB is required for light-mediated inhibition of sexual development and for mycotoxin production inAspergillus nidulans

(2009) Özgür Bayram et al.   MOLECULAR MICROBIOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Positive Selection of Tyrosine Loss in Metazoan Evolution

(2009) C. S. H. Tan et al.   SCIENCE

Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution

(2009) L. J. Holt et al.   SCIENCE

Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation

(2009) Alex N. Bullock et al.   STRUCTURE

Weak functional constraints on phosphoproteomes

(2009) Christian R. Landry et al.   TRENDS IN GENETICS

Evolution of Phosphoregulation: Comparison of Phosphorylation Patterns across Yeast Species

(2009) Pedro Beltrao et al.   PLOS BIOLOGY

Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution

(2008) Sean B. Carroll   CELL

The Ras/cAMP Pathway and the CDK-Like Kinase Ime2 Regulate the MAPK Smk1 and Spore Morphogenesis in Saccharomyces cerevisiae

(2008) C. M. McDonald et al.   GENETICS

Substrate Discrimination among Mitogen-activated Protein Kinases through Distinct Docking Sequence Motifs

(2008) Douglas L. Sheridan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Improved General Amino Acid Replacement Matrix

(2008) S. Q. Le et al.   MOLECULAR BIOLOGY AND EVOLUTION

Highly active and selective endopeptidases with programmed substrate specificities

(2008) Navin Varadarajan et al.   Nature Chemical Biology

Turning a hobby into a job: How duplicated genes find new functions

(2008) Gavin C. Conant et al.   NATURE REVIEWS GENETICS

Evolution of Eukaryotic Transcription Circuits

(2008) B. B. Tuch et al.   SCIENCE