High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

Chemogenomics and orthology‐based design of antibiotic combination therapies

(2016) Sriram Chandrasekaran et al.   Molecular Systems Biology

Similarly Lethal Strains of Extraintestinal Pathogenic Escherichia coli Trigger Markedly Diverse Host Responses in a Zebrafish Model of Sepsis

(2016) Amelia E. Barber et al.   mSphere

Using combination therapy to thwart drug resistance

(2015) Jessica A Hill et al.   Future Microbiology

Bacterial protein networks: properties and functions

(2015) Athanasios Typas et al.   NATURE REVIEWS MICROBIOLOGY

Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion

(2015) Jennifer L. Tenor et al.   mBio

Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery

(2015) Anupam Pradhan et al.   Scientific Reports

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens

(2015) Nicole Robbins et al.   Cell Reports

Using a Sequential Regimen to Eliminate Bacteria at Sublethal Antibiotic Dosages

(2015) Ayari Fuentes-Hernandez et al.   PLOS BIOLOGY

The Extraintestinal Pathogenic Escherichia coli Factor RqlI Constrains the Genotoxic Effects of the RecQ-Like Helicase RqlH

(2015) Colin W. Russell et al.   PLoS Pathogens

Drug repurposing as an alternative for the treatment of recalcitrant bacterial infections

(2015) Adrián Rangel-Vega et al.   Frontiers in Microbiology

What is synergy? The Saariselkä agreement revisited

(2015) Jing Tang et al.   Frontiers in Pharmacology

Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning

(2015) Jan Wildenhain et al.   Cell Systems

The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish

(2015) Eric M. Walton et al.   PLoS One

Practical guidance for nonoccupational postexposure prophylaxis to prevent HIV infection

(2014) Sachin Jain et al.   AIDS

Unraveling the Biology of a Fungal Meningitis Pathogen Using Chemical Genetics

(2014) Jessica C.S. Brown et al.   CELL

In vivozebrafish assays for analyzing drug toxicity

(2014) Demetrio Raldúa et al.   Expert Opinion on Drug Metabolism & Toxicology

Escherichia coli Genes and Pathways Involved in Surviving Extreme Exposure to Ionizing Radiation

(2014) R. T. Byrne et al.   JOURNAL OF BACTERIOLOGY

Bacterial methionine biosynthesis

(2014) M. P. Ferla et al.   MICROBIOLOGY-SGM

Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

(2014) A. Y. Lee et al.   SCIENCE

Combination antibiotic therapy for multidrug-resistant Gram-negative bacteria

(2014) Thomas Tängdén   UPSALA JOURNAL OF MEDICAL SCIENCES

Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches

(2014) T. Roemer et al.   Cold Spring Harbor Perspectives in Medicine

Systematic Phenotyping of a Large-Scale Candida glabrata Deletion Collection Reveals Novel Antifungal Tolerance Genes

(2014) Tobias Schwarzmüller et al.   PLoS Pathogens

Genetic Basis for Vancomycin-Enhanced Cephalosporin Susceptibility in Vancomycin-Resistant Enterococci Revealed Using Counterselection with Dominant-Negative Thymidylate Synthase

(2013) Christopher J. Kristich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Surviving Sepsis Campaign

(2013) R. Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Combination therapy with iron chelation and vancomycin in treating murine staphylococcemia

(2013) G. Luo et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Systems-level antimicrobial drug and drug synergy discovery

(2013) Terry Roemer et al.   Nature Chemical Biology

Drug Repurposing: Far Beyond New Targets for Old Drugs

(2012) T. I. Oprea et al.   AAPS Journal

Combination Therapy for Treatment of Infections with Gram-Negative Bacteria

(2012) P. D. Tamma et al.   CLINICAL MICROBIOLOGY REVIEWS

Mutational consequences of dNTP pool imbalances in E. coli

(2012) Roel M. Schaaper et al.   DNA REPAIR

Inducible SOS Response System of DNA Repair and Mutagenesis in Escherichia coli

(2012) Celina Janion   International Journal of Biological Sciences

Azidothymidine and other chain terminators are mutagenic for template-switch-generated genetic mutations

(2012) T. Seier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zebrafish: A See-Through Host and a Fluorescent Toolbox to Probe Host–Pathogen Interaction

(2012) David M. Tobin et al.   PLoS Pathogens

Antifungal Drug Discovery: Something Old and Something New

(2012) Arielle Butts et al.   PLoS Pathogens

Protein Binding: Do We Ever Learn?

(2011) Markus A. Zeitlinger et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Live Imaging of Disseminated Candidiasis in Zebrafish Reveals Role of Phagocyte Oxidase in Limiting Filamentous Growth

(2011) Kimberly M. Brothers et al.   EUKARYOTIC CELL

Systematic exploration of synergistic drug pairs

(2011) M. Cokol et al.   Molecular Systems Biology

Synergistic Antibacterial and Antibiotic Effects of Bisbenzylisoquinoline Alkaloids on Clinical Isolates of Methicillin-Resistant Staphylococcus Aureus (MRSA)

(2011) Guo-Ying Zuo et al.   MOLECULES

Phenotypic Landscape of a Bacterial Cell

(2010) Robert J. Nichols et al.   CELL

Toxicity and tolerance mechanisms for azidothymidine, a replication gap-promoting agent, in Escherichia coli

(2010) Deani L. Cooper et al.   DNA REPAIR

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

(2010) Kevin Pethe et al.   Nature Communications

Optimal Drug Synergy in Antimicrobial Treatments

(2010) Joseph Peter Torella et al.   PLoS Computational Biology

Defining Fractional Inhibitory Concentration Index Cutoffs for Additive Interactions Based on Self-Drug Additive Combinations, Monte Carlo Simulation Analysis, and In Vitro-In Vivo Correlation Data for Antifungal Drug Combinations against Aspergillus fumigatus

(2009) J. Meletiadis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fluctuation AnaLysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis

(2009) B. M. Hall et al.   BIOINFORMATICS

The use ofin vivozebrafish assays in drug toxicity screening

(2009) Peter M Eimon et al.   Expert Opinion on Drug Metabolism & Toxicology

Combination Antimicrobial Treatment Versus Monotherapy: The Contribution of Meta-analyses

(2009) Mical Paul et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Chemical Genetic Profiling and Characterization of Small-molecule Compounds That Affect the Biosynthesis of Unsaturated Fatty Acids inCandida albicans

(2009) Deming Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in Escherichia coli

(2009) Bryan W. Davies et al.   MOLECULAR CELL

Mechanisms of drug combinations: interaction and network perspectives

(2009) Jia Jia et al.   NATURE REVIEWS DRUG DISCOVERY

Drug interactions and the evolution of antibiotic resistance

(2009) Pamela J. Yeh et al.   NATURE REVIEWS MICROBIOLOGY

Use of Zebrafish to Probe the Divergent Virulence Potentials and Toxin Requirements of Extraintestinal Pathogenic Escherichia coli

(2009) Travis J. Wiles et al.   PLoS Pathogens

Accelerated evolution of resistance in multidrug environments

(2008) M. Hegreness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA