Article
Biochemistry & Molecular Biology
Mariana Pereira, Nuno Vale
Summary: The study found that saquinavir (SAQ) in combination with 5-fluorouracil (5-FU) had a better synergistic effect in treating prostate cancer cells (PC-3) than in treating lung cancer cells (A549).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hyejin Cho, Kwang-Sun Kim
Summary: This study suggests that ciclopirox (CPX) may be used as an alternative or supplement to AZT-based medications for treating opportunistic multidrug-resistant (MDR) Gram-negative bacterial infections. CPX showed higher activity against beta-lactamase-producing Escherichia coli strains and resistance against CPX was not observed.
Article
Infectious Diseases
Wei Zhang, Jinxin Ran, Lu Shang, Lifang Zhang, Mi Wang, Chenzhong Fei, Chan Chen, Feng Gu, Yingchun Liu
Summary: This study evaluated the efficacy of Niclosamide against resistant Gram-positive bacteria and explored its antibacterial mechanism. The results showed that Niclosamide exhibited significant antibacterial activity against Gram-positive bacteria and exerted its antibacterial effect by inhibiting bacterial metabolism and toxin expression.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Vitaly G. Grigorenko, Maria G. Khrenova, Irina P. Andreeva, Maya Yu. Rubtsova, Anastasia I. Lev, Tatiana S. Novikova, Elena V. Detusheva, Nadezhda K. Fursova, Ivan A. Dyatlov, Alexey M. Egorov
Summary: Antibiotic resistance is a global problem and the production and spread of antibiotic-inactivating enzymes pose challenges for clinical treatment and drug design. Drug repurposing is a method to find new targets. It has been found that unithiol is a potential inhibitor of metallo-beta-lactamases and can be used in combination with beta-lactam antibiotics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Hyunjung Lee, Jaehoan Lee, Juchan Hwang, Sinyoung Park, Namyoul Kim, Kideok Kim, Honggun Lee, David Shum, Soojin Jang
Summary: The study screened 182 FDA-approved drugs and identified three potential antibiotic candidates against Staphylococcus aureus. Among them, eltrombopag showed the highest antibacterial activity, with significant potency against not only a drug-sensitive S. aureus strain but also 55 clinical isolates including 35 methicillin-resistant S. aureus.
Article
Chemistry, Medicinal
Ginevra Passeri, Ruby A. Vincent, Zhiyin Xiao, Joshua Northcote-Smith, Kogularamanan Suntharalingam
Summary: We report the encapsulation of an osteosarcoma stem cell potent gallium(III)-diflunisal complex 1 into polymeric nanoparticles, which showed significantly enhanced potency towards osteosarcoma cells. The nanoparticle formulation demonstrated a mechanism of action similar to the payload, inducing DNA damage, downregulation of cyclooxygenase-2, and caspase-dependent apoptosis. This study is the first to demonstrate the effective delivery of an OSC-active metal complex into osteosarcoma cells using polymeric nanoparticles.
Review
Chemistry, Applied
Somaye Rashki, Kasra Asgarpour, Hossein Tarrahimofrad, Maryam Hashemipour, Mohammad Saeid Ebrahimi, Hadis Fathizadeh, Ahmad Khorshidi, Haroon Khan, Zeynab Marzhoseyni, Masoud Salavati-Niasari, Hamed Mirzaei
Summary: Chitosan nanomaterials have gained attention in biomedicine for their high levels of biodegradability and biocompatibility, along with antimicrobial effects. Functional modification with other natural compounds, metallic antimicrobial particles, and antibiotics can enhance the efficiency of chitosan in wound dressing with antimicrobial activity. The antibacterial effect of chitosan is mainly associated with the leakage of intracellular content due to malfunction and altered permeability of the negatively charged cell membrane, on which chitosan is adsorbed. Additionally, chitosan nanoparticles possess favorable features of nanoparticles and their chitosan base, thereby exhibiting strengthened antibacterial potential. Polycations in chitosan nanoparticles target negatively charged bacterial membranes, resulting in a stronger effect on bacterial cells compared to pure chitosan.
CARBOHYDRATE POLYMERS
(2021)
Review
Pharmacology & Pharmacy
Jingyi Hu, Anqi Li, Yueyang Guo, Ting Ma, Siqi Feng
Summary: This review summarizes the main tumor metabolic alterations linked with 5-FU resistance and proposes potential chemotherapy combinations from the perspective of intervening tumor metabolism to overcome 5-FU resistance.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Igor Jose dos Santos Nascimento, Thiago Mendonca de Aquino, Edeildo Ferreira da Silva-Junior
Summary: Viral diseases have caused numerous deaths globally, and drug repurposing is a fast and economically viable technique for finding new treatments for emerging viral diseases.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Biomedical
Inga S. Shchelik, Joao V. D. Molino, Karl Gademann
Summary: Biohybrid microswimmers designed to carry antibiotics against bacterial infections utilize motile microorganisms and a photo-cleavable linker to release drugs on demand, providing high spatial and temporal precision in inhibiting bacterial growth.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
E. Martinez, M. Osorio, C. Finkielstein, I. Ortiz, Maria S. Peresin, C. Castro
Summary: This study used bacterial nanocellulose as an encapsulation material for oral administration of 5FU. The study found that the drug showed controlled release behavior in the colon and improved its toxicity effect and mechanism of action.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Zhihua Lin, Changyong Gao, Daolin Wang, Qiang He
Summary: This study presents a bubble-propelled Janus gallium/zinc (Ga/Zn) micromotor with good biocompatibility and biodegradability, which can actively target bacteria for treatment. The micromotors exhibit self-propulsion in simulated gastroenteric acid and enhanced antibacterial efficiency against H. pylori compared to passive Ga microparticles. The Ga/Zn micromotors combine self-propulsion, biocompatibility, biodegradability, and Ga-based antibacterial properties, showing promise for active treatment of bacterial infections.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Infectious Diseases
Veronica Folliero, Federica Dell'Annunziata, Emanuela Roscetto, Marcella Cammarota, Anna De Filippis, Chiara Schiraldi, Maria Rosaria Catania, Vincenzo Casolaro, Alessandro Perrella, Massimiliano Galdiero, Gianluigi Franci
Summary: This study demonstrates the antimicrobial activity of the anthelmintic drug niclosamide against multidrug-resistant Corynebacterium striatum, showing bactericidal action and biofilm biomass degradation. These findings suggest the potential repurposing of niclosamide as a therapeutic agent for C. striatum infections.
Article
Chemistry, Physical
Fengjun Shi, Sisi Ma, Sen Liu, Rui Xin, Bo Chen, Wei Ye, Jing Sun
Summary: Bacterial infections pose a significant challenge in clinical medicine, and addressing bacterial contamination requires the rational use of biomedical antibacterial materials. Gallium-based materials show promise due to their exceptional antimicrobial properties, combining physical and chemical sterilization. This review examines the main antimicrobial mechanisms of Ga-based materials, including inhibition of Fe metabolism, generation of reactive oxygen species, and physical disruption, and also summarizes their functional applications. Future challenges and developments in Ga-based antimicrobial materials are also discussed.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Andrea Miro Canturri, Younes Smani
Summary: Bacterial infections are a leading cause of death worldwide, and the emergence of antimicrobial resistance poses a serious threat. Repurposing approved drugs may provide a faster and more cost-effective approach to drug development.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Veterinary Sciences
Noah D. Cohen, Nathan M. Slovis, Steeve Giguere, Samantha Baker, M. Keith Chaffin, Lawrence R. Bernstein
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2015)
Article
Veterinary Sciences
Caroline S. Monk, Raymond W. Sweeney, Lawrence R. Bernstein, Marie-Eve Fecteau
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2016)
Article
Microbiology
T. E. Norman, M. Batista, S. D. Lawhon, S. Zhang, K. R. Kuskie, A. K. Swinford, L. R. Bernstein, N. D. Cohen
JOURNAL OF CLINICAL MICROBIOLOGY
(2014)
Article
Pharmacology & Pharmacy
F. Sampieri, A. L. Allen, J. Alcorn, C. R. Clark, F. A. Vannucci, N. Pusterla, S. M. Mapes, K. R. Ball, P. M. Dowling, J. Thompson, L. R. Bernstein, C. J. Gebhart, D. L. Hamilton
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2014)
Article
Pharmacology & Pharmacy
F. Sampieri, J. Alcorn, A. L. Allen, C. R. Clark, F. A. Vannucci, N. Pusterla, S. Mapes, K. R. Ball, P. M. Dowling, J. Thompson, L. R. Bernstein, C. J. Gebhart, D. L. Hamilton
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2014)
Article
Anesthesiology
Lawrence R. Bernstein
Article
Veterinary Sciences
Marie-Eve Fecteau, Helen W. Aceto, Lawrence R. Bernstein, Raymond W. Sweeney
VETERINARY JOURNAL
(2014)
Article
Microbiology
Carolyn E. Arnold, Angela Bordin, Sara D. Lawhon, Melissa C. Libal, Lawrence R. Bernstein, Noah D. Cohen
VETERINARY MICROBIOLOGY
(2012)
Article
Immunology
Sarah Hijazi, Daniela Visaggio, Mattia Pirolo, Emanuela Frangipani, Lawrence Bernstein, Paolo Visca
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Infectious Diseases
Lorenzo Giacani, Lawrence R. Bernstein, Austin M. Haynes, B. Charmie Godornes, Giulia Ciccarese, Francesco Drago, Aurora Parodi, Sefora Valdevit, Luca Anselmi, Carlo Francesco Tomasini, Arthur M. Baca
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Engineering, Biomedical
Stacy Cereceres, Ziyang Lan, Laura Bryan, Michael Whitely, Thomas Wilems, Hunter Greer, Ellen Ruth Alexander, Robert J. Taylor, Lawrence Bernstein, Noah Cohen, Canaan Whitfield-Cargile, Elizabeth Cosgriff-Hernandez
APL BIOENGINEERING
(2019)
Meeting Abstract
Veterinary Sciences
F. Sampieri, A. L. Allen, J. Alcorn, C. R. Clark, F. A. Vannucci, N. Pusterla, K. R. Ball, P. M. Dowling, J. Thompson, L. R. Bernstein, C. J. Gebhart, D. L. Hamilton
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2012)
Meeting Abstract
Veterinary Sciences
F. Sampieri, J. Alcorn, A. L. Allen, C. R. Clark, F. A. Vannucci, N. Pusterla, K. R. Ball, P. M. Dowling, J. Thompson, L. R. Bernstein, C. J. Gebhart, D. L. Hamilton
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2012)
Article
Oncology
Lawrence R. Bernstein, Jacobus J. M. van der Hoeven, Robbert O. Boer
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2011)