标题
Systems-level antimicrobial drug and drug synergy discovery
作者
关键词
-
出版物
Nature Chemical Biology
Volume 9, Issue 4, Pages 222-231
出版商
Springer Nature
发表日期
2013-03-19
DOI
10.1038/nchembio.1205
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening
- (2012) Sarah A. Stanley et al. ACS Chemical Biology
- Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams
- (2012) Maya A. Farha et al. ACS Chemical Biology
- Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I
- (2012) Alex G. Therien et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Global Phenotypic Screening for Antimalarials
- (2012) W. Armand Guiguemde et al. CHEMISTRY & BIOLOGY
- Towards a new tuberculosis drug: pyridomycin - nature's isoniazid
- (2012) Ruben C. Hartkoorn et al. EMBO Molecular Medicine
- Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
- (2012) Anna E Grzegorzewicz et al. Nature Chemical Biology
- Phylogeny and beyond: Scientific, historical, and conceptual significance of the first tree of life
- (2012) N. R. Pace et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to -Lactam Antibiotics
- (2012) C. M. Tan et al. Science Translational Medicine
- Identification and in vitro Analysis of the GatD/MurT Enzyme-Complex Catalyzing Lipid II Amidation in Staphylococcus aureus
- (2012) Daniela Münch et al. PLoS Pathogens
- Parsimonious Discovery of Synergistic Drug Combinations
- (2011) Bryan Severyn et al. ACS Chemical Biology
- A Chemical Genomic Analysis of Decoquinate, aPlasmodium falciparumCytochromebInhibitor
- (2011) Tae-gyu Nam et al. ACS Chemical Biology
- Reshuffling of Aspergillus fumigatus Cell Wall Components Chitin and β-Glucan under the Influence of Caspofungin or Nikkomycin Z Alone or in Combination
- (2011) Patricia E. B. Verwer et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Antagonism of Chemical Genetic Interaction Networks Resensitize MRSA to β-Lactam Antibiotics
- (2011) Sang Ho Lee et al. CHEMISTRY & BIOLOGY
- Confronting the Challenges of Natural Product-Based Antifungal Discovery
- (2011) Terry Roemer et al. CHEMISTRY & BIOLOGY
- Compound Prioritization Methods Increase Rates of Chemical Probe Discovery in Model Organisms
- (2011) Iain M. Wallace et al. CHEMISTRY & BIOLOGY
- Challenges of Antibacterial Discovery
- (2011) L. L. Silver CLINICAL MICROBIOLOGY REVIEWS
- Antibiotic adjuvants: multicomponent anti-infective strategies
- (2011) Lindsay Kalan et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Discovery research: the scientific challenge of finding new antibiotics
- (2011) D. M. Livermore et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease
- (2011) R. S. Shapiro et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- Systematic exploration of synergistic drug pairs
- (2011) M. Cokol et al. Molecular Systems Biology
- Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy
- (2011) Linda Ejim et al. Nature Chemical Biology
- How were new medicines discovered?
- (2011) David C. Swinney et al. NATURE REVIEWS DRUG DISCOVERY
- Genomewide Screening for Novel Genetic Variations Associated with Ciprofloxacin Resistance in Bacillus anthracis
- (2010) M. Serizawa et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Staphylococcus aureus TargetArray: Comprehensive Differential Essential Gene Expression as a Mechanistic Tool To Profile Antibacterials
- (2010) H. H. Xu et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code
- (2010) A. Liu et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production
- (2010) J. H. Moffatt et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Lipoprotein Cofactors Located in the Outer Membrane Activate Bacterial Cell Wall Polymerases
- (2010) Catherine Paradis-Bleau et al. CELL
- Phenotypic Landscape of a Bacterial Cell
- (2010) Robert J. Nichols et al. CELL
- Chemical Genomic Approaches to Study Model Microbes
- (2010) Courtney A. Barker et al. CHEMISTRY & BIOLOGY
- Three Decades of -Lactamase Inhibitors
- (2010) S. M. Drawz et al. CLINICAL MICROBIOLOGY REVIEWS
- The antibiotic resistome
- (2010) Gerard D Wright Expert Opinion on Drug Discovery
- Essentiality of FASII pathway for Staphylococcus aureus
- (2010) Wendy Balemans et al. NATURE
- Quantitative analysis of fitness and genetic interactions in yeast on a genome scale
- (2010) Anastasia Baryshnikova et al. NATURE METHODS
- An insight into the antifungal pipeline: selected new molecules and beyond
- (2010) Luis Ostrosky-Zeichner et al. NATURE REVIEWS DRUG DISCOVERY
- Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model
- (2010) J. M. Becker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Genetic Landscape of a Cell
- (2010) M. Costanzo et al. SCIENCE
- The Bacterial Cell Envelope
- (2010) T. J. Silhavy et al. Cold Spring Harbor Perspectives in Biology
- Gene Annotation and Drug Target Discovery in Candida albicans with a Tagged Transposon Mutant Collection
- (2010) Julia Oh et al. PLoS Pathogens
- Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)
- (2009) Roy R Chaudhuri et al. BMC GENOMICS
- A Staphylococcus aureus Fitness Test Platform for Mechanism-Based Profiling of Antibacterial Compounds
- (2009) Robert G.K. Donald et al. CHEMISTRY & BIOLOGY
- Chemical Genetic Identification of Peptidoglycan Inhibitors Potentiating Carbapenem Activity against Methicillin-Resistant Staphylococcus aureus
- (2009) Joann Huber et al. CHEMISTRY & BIOLOGY
- New triazoles and echinocandins: mode of action,in vitroactivity and mechanisms of resistance
- (2009) Maria Teresa Fera et al. Expert Review of Anti-Infective Therapy
- Quantitative phenotyping via deep barcode sequencing
- (2009) A. M. Smith et al. GENOME RESEARCH
- Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants
- (2009) G. C. Langridge et al. GENOME RESEARCH
- Cyslabdan, a New Potentiator of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Streptomyces sp. K04-0144
- (2009) Atsushi Fukumoto et al. JOURNAL OF ANTIBIOTICS
- Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi
- (2009) Gerald F. Bills et al. MYCOLOGIA
- Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens
- (2009) Sophie Brinster et al. NATURE
- A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
- (2009) Cheuk Hei Ho et al. NATURE BIOTECHNOLOGY
- Synergistic drug combinations tend to improve therapeutically relevant selectivity
- (2009) Joseph Lehár et al. NATURE BIOTECHNOLOGY
- Genetic Architecture of Intrinsic Antibiotic Susceptibility
- (2009) Hany S. Girgis et al. PLoS One
- Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
- (2009) Leah E. Cowen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antibiotics for Emerging Pathogens
- (2009) M. A. Fischbach et al. SCIENCE
- Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin
- (2009) Sheena D. Singh et al. PLoS Pathogens
- Systematic Mapping of Genetic Interaction Networks
- (2008) Scott J. Dixon et al. Annual Review of Genetics
- PAP Inhibitor with In Vivo Efficacy Identified by Candida albicans Genetic Profiling of Natural Products
- (2008) Bo Jiang et al. CHEMISTRY & BIOLOGY
- Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America
- (2008) Helen W. Boucher et al. CLINICAL INFECTIOUS DISEASES
- Whither antibacterial drug discovery?
- (2008) Steven J. Projan DRUG DISCOVERY TODAY
- Antifungal activity against Candida albicans of nikkomycin Z in combination with caspofungin, voriconazole or amphotericin B
- (2008) H. Sandovsky-Losica et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Determination of Antibiotic Hypersensitivity among 4,000 Single-Gene-Knockout Mutants of Escherichia coli
- (2008) C. Tamae et al. JOURNAL OF BACTERIOLOGY
- A complete collection of single-gene deletion mutants of Acinetobacter baylyi ADP1
- (2008) Véronique de Berardinis et al. Molecular Systems Biology
- An integrated platform of genomic assays reveals small-molecule bioactivities
- (2008) Shawn Hoon et al. Nature Chemical Biology
- Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers
- (2008) Zhun Yan et al. NATURE METHODS
- The Neglected Intrinsic Resistome of Bacterial Pathogens
- (2008) Alicia Fajardo et al. PLoS One
- Defining genetic interaction
- (2008) R. Mani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity
- (2008) D. J. Haydon et al. SCIENCE
- Yeast chemical genomics and drug discovery: an update
- (2008) Shawn Hoon et al. TRENDS IN PHARMACOLOGICAL SCIENCES
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