Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

A High-Throughput Yeast Assay Identifies Synergistic Drug Combinations

(2013) Nikko P. Torres et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

GO-Elite: a flexible solution for pathway and ontology over-representation

(2012) Alexander C. Zambon et al.   BIOINFORMATICS

Cystic fibrosis in an era of genomically guided therapy

(2012) P. M. Barrett et al.   HUMAN MOLECULAR GENETICS

The BioGRID interaction database: 2013 update

(2012) Andrew Chatr-aryamontri et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Electron Transport Is the Cellular Target of the Oncology Drug Elesclomol

(2012) Ronald K. Blackman et al.   PLoS One

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

Compound Prioritization Methods Increase Rates of Chemical Probe Discovery in Model Organisms

(2011) Iain M. Wallace et al.   CHEMISTRY & BIOLOGY

Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution

(2011) Gabriel Schaaf et al.   MOLECULAR BIOLOGY OF THE CELL

Probing the links between in vitro potency, ADMET and physicochemical parameters

(2011) M. Paul Gleeson et al.   NATURE REVIEWS DRUG DISCOVERY

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

Supervised normalization of microarrays

(2010) Brigham H. Mecham et al.   BIOINFORMATICS

Cytoscape 2.8: new features for data integration and network visualization

(2010) M. E. Smoot et al.   BIOINFORMATICS

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

(2010) P. A. Spagnuolo et al.   BLOOD

An improved method for scoring protein-protein interactions using semantic similarity within the Gene Ontology

(2010) Shobhit Jain et al.   BMC BIOINFORMATICS

The Antidepressant Sertraline Targets Intracellular Vesiculogenic Membranes in Yeast

(2010) M. M. Rainey et al.   GENETICS

A Consensus of Core Protein Complex Compositions for Saccharomyces cerevisiae

(2010) Joris J. Benschop et al.   MOLECULAR CELL

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Requirement for Ergosterol in V-ATPase Function Underlies Antifungal Activity of Azole Drugs

(2010) Yong-Qiang Zhang et al.   PLoS Pathogens

HAUS, the 8-Subunit Human Augmin Complex, Regulates Centrosome and Spindle Integrity

(2009) Steffen Lawo et al.   CURRENT BIOLOGY

Forchlorfenuron Alters Mammalian Septin Assembly, Organization, and Dynamics

(2008) Qicong Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Anatomy of Phospholipid Binding and Regulation of Phosphoinositide Homeostasis by Proteins of the Sec14 Superfamily

(2008) Gabriel Schaaf et al.   MOLECULAR CELL

An integrated platform of genomic assays reveals small-molecule bioactivities

(2008) Shawn Hoon et al.   Nature Chemical Biology

The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

(2008) M. E. Hillenmeyer et al.   SCIENCE

Graph Clustering Via a Discrete Uncoupling Process

(2008) Stijn Van Dongen   SIAM JOURNAL ON MATRIX ANALYSIS AND APPLICATIONS