Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells

TZAP: A telomere-associated protein involved in telomere length control

(2017) Julia Su Zhou Li et al.   SCIENCE

Hsp90-binding immunophilin FKBP52 modulates telomerase activity by promoting the cytoplasmic retrotransport of hTERT

(2016) Y. Y. Jeong et al.   BIOCHEMICAL JOURNAL

Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia

(2016) H. E. Speedy et al.   BLOOD

Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres

(2016) Jens C. Schmidt et al.   CELL

The proper connection between shelterin components is required for telomeric heterochromatin assembly

(2016) Jiyong Wang et al.   GENES & DEVELOPMENT

Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression

(2016) Ekta Khattar et al.   JOURNAL OF CLINICAL INVESTIGATION

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

(2016) Delphine Benarroch-Popivker et al.   MOLECULAR CELL

Single-molecule FRET-Rosetta reveals RNA structural rearrangements during human telomerase catalysis

(2016) Joseph W. Parks et al.   RNA

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

(2016) Mohammad A. Jafri et al.   Genome Medicine

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces

(2016) Xichan Hu et al.   eLife

Enforced telomere elongation increases the sensitivity of human tumour cells to ionizing radiation

(2015) Jennifer Fairlie et al.   DNA REPAIR

RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends

(2015) J. Audry et al.   EMBO JOURNAL

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

(2015) M. Garcia-Beccaria et al.   EMBO Molecular Medicine

Human telomerase: biogenesis, trafficking, recruitment, and activation

(2015) Jens C. Schmidt et al.   GENES & DEVELOPMENT

Dysregulation of shelterin factors coupled with telomere shortening in Philadelphia chromosome negative myeloproliferative neoplasms

(2015) J. Dahlstrom et al.   HAEMATOLOGICA

Role of TERRA in the Regulation of Telomere Length

(2015) Caiqin Wang et al.   International Journal of Biological Sciences

Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction

(2015) Céline Reyes et al.   JOURNAL OF CELL BIOLOGY

Contributions of the TEL-patch Amino Acid Cluster on TPP1 to Telomeric DNA Synthesis by Human Telomerase

(2015) Andrew B. Dalby et al.   JOURNAL OF MOLECULAR BIOLOGY

Cell death during crisis is mediated by mitotic telomere deprotection

(2015) Makoto T. Hayashi et al.   NATURE

A DNA-hairpin model for repeat-addition processivity in telomere synthesis

(2015) Wei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids

(2015) B. M. Akiyama et al.   NUCLEIC ACIDS RESEARCH

Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532

(2015) Christopher Bryan et al.   STRUCTURE

No DDRama at chromosome ends: TRF2 takes centre stage

(2015) Sascha Feuerhahn et al.   TRENDS IN BIOCHEMICAL SCIENCES

A DNA-hairpin model for repeat-addition processivity in telomere synthesis

(2015) Wei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

(2015) Adrian S. Tong et al.   Cell Reports

ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells

(2015) Stella Suyong Lee et al.   Cell Reports

Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis

(2015) Jinqiang Liu et al.   Cell Reports

The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres

(2015) Amanda K. Frank et al.   PLoS Genetics

Dysregulation of shelterin factors coupled with telomere shortening in Philadelphia chromosome negative myeloproliferative neoplasms

(2015) J. Dahlstrom et al.   HAEMATOLOGICA

Quantification of hTERT Splice Variants in Melanoma by SYBR Green Real-time Polymerase Chain Reaction Indicates a Negative Regulatory Role for the β Deletion Variant

(2015) Lisa F. Lincz et al.   NEOPLASIA

Telomerase Activation after Recruitment in Fission Yeast

(2014) Christine Anne Armstrong et al.   CURRENT BIOLOGY

Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex

(2014) R. A. Wu et al.   EMBO JOURNAL

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

(2014) Alec N. Sexton et al.   GENES & DEVELOPMENT

Nonsense Mutations in the Shelterin Complex Genes ACD and TERF2IP in Familial Melanoma

(2014) Lauren G. Aoude et al.   JNCI-Journal of the National Cancer Institute

POT1 loss-of-function variants predispose to familial melanoma

(2014) Carla Daniela Robles-Espinoza et al.   NATURE GENETICS

Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma

(2014) Jianxin Shi et al.   NATURE GENETICS

Transcriptional outcome of telomere signalling

(2014) Jing Ye et al.   NATURE REVIEWS GENETICS

Telomere Length and Telomerase Activity in Bovine Pre-implantation EmbryosIn Vitro

(2014) GC Gilchrist et al.   REPRODUCTION IN DOMESTIC ANIMALS

Single-molecule real-time detection of telomerase extension activity

(2014) Helen Hwang et al.   Scientific Reports

Identification of human TERT elements necessary for telomerase recruitment to telomeres

(2014) Jens C Schmidt et al.   eLife

The Major Reverse Transcriptase-Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis

(2013) I. Listerman et al.   CANCER RESEARCH

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1

(2013) H.-I. Jun et al.   GENES & DEVELOPMENT

Finding the end: recruitment of telomerase to telomeres

(2013) Jayakrishnan Nandakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment

(2013) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Est3 reveals a bimodal surface with differential roles in telomere replication

(2013) T. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A quantitative telomeric chromatin isolation protocol identifies different telomeric states

(2013) Larissa Grolimund et al.   Nature Communications

Novel anticancer therapeutics targeting telomerase

(2012) Maria Ruden et al.   CANCER TREATMENT REVIEWS

Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST

(2012) Peng Wu et al.   CELL

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

(2012) Franklin L. Zhong et al.   CELL

A role for sister telomere cohesion in telomere elongation by telomerase

(2012) Benjamin R. Houghtaling et al.   CELL CYCLE

CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion

(2012) Peili Gu et al.   EMBO JOURNAL

Tel1ATM and Rad3ATR phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast

(2012) H. Yamazaki et al.   GENES & DEVELOPMENT

Schizosaccharomyces pombe Ccq1 and TER1 bind the 14-3-3-like domain of Est1, which promotes and stabilizes telomerase-telomere association

(2012) C. J. Webb et al.   GENES & DEVELOPMENT

Specificity Requirements for Human Telomere Protein Interaction with Telomerase Holoenzyme

(2012) Alec N. Sexton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Enhanced H/ACA RNP Assembly Mechanism for Human Telomerase RNA

(2012) E. D. Egan et al.   MOLECULAR AND CELLULAR BIOLOGY

Taz1 Enforces Cell-Cycle Regulation of Telomere Synthesis

(2012) Pierre-Marie Dehé et al.   MOLECULAR CELL

Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes

(2012) Wen Tang et al.   NATURE

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

(2012) Jayakrishnan Nandakumar et al.   NATURE

The human CST complex is a terminator of telomerase activity

(2012) Liuh-Yow Chen et al.   NATURE

Quantification of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase and Correlations with Telomerase Activity in Lung Cancer

(2012) Yan Liu et al.   PLoS One

Telomerase and Telomere-Associated Proteins: Structural Insights into Mechanism and Evolution

(2012) Karen A. Lewis et al.   STRUCTURE

A role for heterochromatin protein 1  at human telomeres

(2011) S. Canudas et al.   GENES & DEVELOPMENT

Stimulation of Yeast Telomerase Activity by the Ever Shorter Telomere 3 (Est3) Subunit Is Dependent on Direct Interaction with the Catalytic Protein Est2

(2011) Jennell M. Talley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Telomerase Domain Interactions Capture DNA for TEN Domain-Dependent Processive Elongation

(2011) Aaron R. Robart et al.   MOLECULAR CELL

Is telomerase a viable target in cancer?

(2011) C.M. Buseman et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast

(2011) Bettina A Moser et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro

(2011) Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Saccharomyces cerevisiae Telomerase Subunit Est3 Binds Telomeres in a Cell Cycle– and Est1–Dependent Manner and Interacts Directly with Est1 In Vitro

(2011) Creighton T. Tuzon et al.   PLoS Genetics

Telomeric Strategies: Means to an End

(2010) Devanshi Jain et al.   Annual Review of Genetics

POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation

(2010) Chrysa M Latrick et al.   EMBO JOURNAL

Ccq1p and the Condensin Proteins Cut3p and Cut14p Prevent Telomere Entanglements in the Fission Yeast Schizosaccharomyces pombe

(2010) Tina Motwani et al.   EUKARYOTIC CELL

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo

(2010) E. Abreu et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomere lengths in human oocytes, cleavage stage embryos and blastocysts

(2010) S. Turner et al.   MOLECULAR HUMAN REPRODUCTION

Telomeres avoid end detection by severing the checkpoint signal transduction pathway

(2010) Tiago Carneiro et al.   NATURE

A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity

(2010) Mingyi Xie et al.   NUCLEIC ACIDS RESEARCH

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression

(2009) Shang Li et al.   CELL

Telomere Extension Occurs at Most Chromosome Ends and Is Uncoupled from Fill-In in Human Cancer Cells

(2009) Yong Zhao et al.   CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase

(2009) David Shore et al.   EMBO JOURNAL

Human RAP1 inhibits non-homologous end joining at telomeres

(2009) Jay Sarthy et al.   EMBO JOURNAL

In VivoStoichiometry of Shelterin Components

(2009) Kaori K. Takai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells

(2009) Silvia Canudas et al.   JOURNAL OF CELL BIOLOGY

RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway

(2009) Yasuyuki Miyake et al.   MOLECULAR CELL

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

(2009) A. S. Venteicher et al.   SCIENCE

Fission Yeast Tel1ATM and Rad3ATR Promote Telomere Protection and Telomerase Recruitment

(2009) Bettina A. Moser et al.   PLoS Genetics

TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita

(2008) Sharon A. Savage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels

(2008) Y. Cao et al.   CANCER RESEARCH

Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller

(2008) K. Tomita et al.   GENES & DEVELOPMENT

The Est3 protein associates with yeast telomerase through an OB-fold domain

(2008) Jaesung Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetic regulation of telomeres in human cancer

(2008) E Vera et al.   ONCOGENE

Fission Yeast Pot1-Tpp1 Protects Telomeres and Regulates Telomere Length

(2008) T. Miyoshi et al.   SCIENCE