Finding the end: recruitment of telomerase to telomeres

Drosophila Telomeres: A Variation on the Telomerase Theme

(2014) Mary-Lou Pardue et al.   FLY

Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model

(2012) Jennifer S. Pfingsten et al.   CELL

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

(2012) Franklin L. Zhong et al.   CELL

A role for sister telomere cohesion in telomere elongation by telomerase

(2012) Benjamin R. Houghtaling et al.   CELL CYCLE

Telomeres: The beginnings and ends of eukaryotic chromosomes

(2012) Virginia A. Zakian   EXPERIMENTAL CELL RESEARCH

Tel1ATM and Rad3ATR phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast

(2012) H. Yamazaki et al.   GENES & DEVELOPMENT

Schizosaccharomyces pombe Ccq1 and TER1 bind the 14-3-3-like domain of Est1, which promotes and stabilizes telomerase-telomere association

(2012) C. J. Webb et al.   GENES & DEVELOPMENT

Specificity Requirements for Human Telomere Protein Interaction with Telomerase Holoenzyme

(2012) Alec N. Sexton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes

(2012) Wen Tang et al.   NATURE

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

(2012) Jayakrishnan Nandakumar et al.   NATURE

Stiffened yeast telomerase RNA supports RNP function in vitro and in vivo

(2012) K. J. Lebo et al.   RNA

Biogenesis of telomerase ribonucleoproteins

(2012) E. D. Egan et al.   RNA

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

Telomerase and Telomere-Associated Proteins: Structural Insights into Mechanism and Evolution

(2012) Karen A. Lewis et al.   STRUCTURE

Schizosaccharomyces pombeProtection of Telomeres 1 Utilizes Alternate Binding Modes To Accommodate Different Telomeric Sequences

(2011) Sarah E. Altschuler et al.   BIOCHEMISTRY

Three novel truncating TINF2 mutations causing severe dyskeratosis congenita in early childhood

(2011) GS Sasa et al.   CLINICAL GENETICS

RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency

(2011) Xiaodong Qi et al.   EMBO JOURNAL

A role for heterochromatin protein 1  at human telomeres

(2011) S. Canudas et al.   GENES & DEVELOPMENT

Stimulation of Yeast Telomerase Activity by the Ever Shorter Telomere 3 (Est3) Subunit Is Dependent on Direct Interaction with the Catalytic Protein Est2

(2011) Jennell M. Talley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TIN2 Protein Dyskeratosis Congenita Missense Mutants Are Defective in Association with Telomerase

(2011) Dong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple POT1–TPP1 Proteins Coat and Compact Long Telomeric Single-Stranded DNA

(2011) Derek J. Taylor et al.   JOURNAL OF MOLECULAR BIOLOGY

Processive and Distributive Extension of Human Telomeres by Telomerase under Homeostatic and Nonequilibrium Conditions

(2011) Yong Zhao et al.   MOLECULAR CELL

Telomerase regulation

(2011) Catherine Cifuentes-Rojas et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast

(2011) Helder C. Ferreira et al.   NATURE CELL BIOLOGY

The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis

(2011) Andrea J Berman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast

(2011) Bettina A Moser et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase

(2011) Q. Wang et al.   NUCLEIC ACIDS RESEARCH

DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe

(2011) Jayakrishnan Nandakumar et al.   NUCLEIC ACIDS RESEARCH

Telomerase regulatory subunit Est3 in two Candida species physically interacts with the TEN domain of TERT and telomeric DNA

(2011) W.-F. Yen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-protein binding interface in the telomerase ribonucleoprotein

(2011) C. J. Bley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro

(2011) Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ku Must Load Directly onto the Chromosome End in Order to Mediate Its Telomeric Functions

(2011) Christopher R. Lopez et al.   PLoS Genetics

The Saccharomyces cerevisiae Telomerase Subunit Est3 Binds Telomeres in a Cell Cycle– and Est1–Dependent Manner and Interacts Directly with Est1 In Vitro

(2011) Creighton T. Tuzon et al.   PLoS Genetics

Dyskeratosis Congenita

(2011) I. Dokal   Hematology-American Society of Hematology Education Program

Is there a telmore-bound ‘EST’ telomerase holoenzyme?

(2010) Diane C. DeZwaan et al.   CELL CYCLE

Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α

(2010) Jia Sun et al.   CELL RESEARCH

TPP1 Is Required for TERT Recruitment, Telomere Elongation during Nuclear Reprogramming, and Normal Skin Development in Mice

(2010) Agueda M. Tejera et al.   DEVELOPMENTAL CELL

POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation

(2010) Chrysa M Latrick et al.   EMBO JOURNAL

Dyskeratosis congenita

(2010) Monica Bessler et al.   FEBS LETTERS

Functional interaction between telomere protein TPP1 and telomerase

(2010) A. J. Zaug et al.   GENES & DEVELOPMENT

Single Molecule Studies of Physiologically Relevant Telomeric Tails Reveal POT1 Mechanism for Promoting G-quadruplex Unfolding

(2010) Hong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo

(2010) E. Abreu et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA

(2010) Meghan Mitchell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct involvement of the TEN domain at the active site of human telomerase

(2010) Julie Jurczyluk et al.   NUCLEIC ACIDS RESEARCH

Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression

(2009) Shang Li et al.   CELL

Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres

(2009) Bettina A Moser et al.   EMBO JOURNAL

Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination

(2009) H. Schober et al.   GENES & DEVELOPMENT

In VivoStoichiometry of Shelterin Components

(2009) Kaori K. Takai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conserved WD40 Protein Binds the Cajal Body Localization Signal of scaRNP Particles

(2009) Kazimierz T. Tycowski et al.   MOLECULAR CELL

The effect of the TRF2 N-terminal and TRFH regions on telomeric G-quadruplex structures

(2009) Ilene M. Pedroso et al.   NUCLEIC ACIDS RESEARCH

Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13

(2009) Shun-Fu Tseng et al.   NUCLEIC ACIDS RESEARCH

Human Telomerase Reverse Transcriptase (hTERT) Q169 Is Essential for Telomerase Function In Vitro and In Vivo

(2009) Haley D. M. Wyatt et al.   PLoS One

The conserved Est1 protein stimulates telomerase DNA extension activity

(2009) D. C. DeZwaan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

(2009) A. S. Venteicher et al.   SCIENCE

Fission Yeast Tel1ATM and Rad3ATR Promote Telomere Protection and Telomerase Recruitment

(2009) Bettina A. Moser et al.   PLoS Genetics

TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita

(2008) Sharon A. Savage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes

(2008) A. J. Walne et al.   BLOOD

TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres

(2008) Franck Gallardo et al.   EMBO JOURNAL

A Flexible Template Boundary Element in the RNA Subunit of Fission Yeast Telomerase

(2008) Jessica A. Box et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spliceosomal cleavage generates the 3′ end of telomerase RNA

(2008) Jessica A. Box et al.   NATURE

Structure of the Tribolium castaneum telomerase catalytic subunit TERT

(2008) Andrew J. Gillis et al.   NATURE

The Est3 protein associates with yeast telomerase through an OB-fold domain

(2008) Jaesung Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A proposed OB-fold with a protein-interaction surface in Candida albicans telomerase protein Est3

(2008) Eun Young Yu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Triple-helix structure in telomerase RNA contributes to catalysis

(2008) Feng Qiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multiple DNA-binding sites in Tetrahymena telomerase

(2008) Sharon N. Finger et al.   NUCLEIC ACIDS RESEARCH

A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins

(2008) Y. Chen et al.   SCIENCE

Fission Yeast Pot1-Tpp1 Protects Telomeres and Regulates Telomere Length

(2008) T. Miyoshi et al.   SCIENCE

ATM-like kinases and regulation of telomerase: lessons from yeast and mammals

(2008) Michelle Sabourin et al.   TRENDS IN CELL BIOLOGY

Two Pathways Recruit Telomerase to Saccharomyces cerevisiae Telomeres

(2008) Angela Chan et al.   PLoS Genetics

Comparison between TRF2 and TRF1 of their telomeric DNA-bound structures and DNA-binding activities

(2004) Shingo Hanaoka et al.   PROTEIN SCIENCE