Article
Medicine, Research & Experimental
Qianqian Zhang, Wei Feng, Qingting Wang, Jian Wang, Limin Chai, Yuqian Chen, Yan Wang, Jin Liu, Manxiang Li, Xinming Xie
Summary: Vascular remodeling is a significant feature of pulmonary artery hypertension (PAH), characterized by abnormal proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). This study explores the role of telomerase reverse transcriptase (TERT) in mediating PASMCs proliferation and migration, with PDGF being shown to upregulate TERT expression and telomerase activation by activating Akt and upregulating c-MYC. Inhibition of Akt, knockdown of c-MYC, or suppression of telomerase activity repressed PDGF-induced PASMCs proliferation and migration. Furthermore, activation of peroxisome proliferator-activated receptor (PPAR) suppressed TERT expression and telomerase activation, leading to the inhibition of PASMCs proliferation and migration.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Li Tao, Wei Zhang, Yaxin Zhang, Mei Zhang, Yueying Zhang, Xing Niu, Qing Zhao, Zhenxing Liu, Yuyin Li, Aipo Diao
Summary: The study showed that caffeine can promote the expression of TERT to extend telomere length and prevent cellular senescence. In animal studies, caffeine also reversed the decline in organ index and improved tissue structure in aging mice. These results suggest that caffeine-containing foods can delay cellular senescence and aging through the expression of TERT.
Article
Biology
Hueng-Chuen Fan, Fung-Wei Chang, Jeng-Dau Tsai, Kao-Min Lin, Chuan-Mu Chen, Shinn-Zong Lin, Ching-Ann Liu, Horng-Jyh Harn
Summary: Telomeres cap the ends of eukaryotic chromosomes and are essential for genome protection and replication. The maintenance of telomere length is regulated by various factors and dysfunctions in telomere maintenance and telomerase activation are associated with diseases, particularly cancer. Understanding the molecular mechanisms behind telomere length regulation and protection is crucial for future therapeutic opportunities.
Article
Oncology
Olivier Adotevi, Dewi Vernerey, Pascale Jacoulet, Aurelia Meurisse, Caroline Laheurte, Hamadi Almotlak, Marion Jacquin, Vincent Kaulek, Laura Boullerot, Marine Malfroy, Emeline Orillard, Guillaume Eberst, Aurelie Lagrange, Laure Favier, Marie Gainet-Brun, Ludovic Doucet, Luis Teixeira, Zineb Ghrieb, Anne-Laure Clairet, Yves Guillaume, Marie Kroemer, Didier Hocquet, Melanie Moltenis, Samuel Limat, Elisabeth Quoix, Celine Mascaux, Didier Debieuvre, Christine Fagnoni-Legat, Christophe Borg, Virginie Westeel
Summary: The purpose of this study was to test the safety, immunogenicity, and efficacy of UCPVax vaccine in patients with metastatic non-small-cell lung cancer. The results showed that UCPVax vaccine was highly immunogenic and safe, and achieved interesting 1-year survival rate in advanced NSCLC patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shuang Li, Qian Xin, Guangyao Fang, Yi Deng, Fengyuan Yang, Chenming Qiu, Yongjian Yang, Cong Lan
Summary: Physical exercise can prevent cardiac hypertrophy by upregulating mitochondrial TERT expression. Overexpression of mitochondrial-targeted TERT improves mitochondrial dysfunction and reduces oxidative stress, leading to the attenuation of cardiac hypertrophy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Chemistry, Medicinal
Lin Zhu, Zhenchao Liu, Yuqian Ren, Xiaolin Wu, Yingjuan Liu, Tingting Wang, Yizhao Li, Yusheng Cong, Yunliang Guo
Summary: Salidroside isolated from Rhodiola rosea L has been found to have potential therapeutic effects on hippocampal neuron senescence and injury. It can increase cell viability, reduce beta-galactosidase levels, improve cognition dysfunction in ageing mice, and alleviate neuronal degeneration in the CA1 region of ageing mice. Additionally, salidroside may exert its protective effects through reducing oxidative stress levels, inhibiting p21 and p16 protein expressions, and promoting telomerase reverse transcriptase protein expression.
PHYTOTHERAPY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Bo Wang, Jianping Jiang, Yun Zhang, Yingying Shen, Liqiang Wu, Siqi Tang, Shengyun Lin
Summary: The study investigated the use of plant extracts as potential therapeutic strategies for cancer treatment, particularly in high-risk MDS patients. The newly extracted coumarin HDE from Oldenlandia diffusa Willd efficiently inhibited MDS cell proliferation and induced apoptosis, with the combination of HDE and BIIB021 showing synergistic antitumor effects on SKM-1 cells, providing a novel therapeutic combination for higher-risk MDS.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jeff Sherman, Grant Verstandig, Yisroel Brumer
Summary: Advancements in biotechnology and machine learning have created a conducive environment for exploring relationships between genomic and epigenetic data with potential therapeutic implications. The study found that CRISPR knockout has strong efficacy in inhibiting growth of tumor cells with varying levels of TERT expression, providing key biomarkers for therapeutic efficacy and potential pathways for drug development. These findings further support the potential of artificial intelligence in oncology.
Article
Medicine, General & Internal
Piotr Macek, Mieszko Wieckiewicz, Rafal Poreba, Pawel Gac, Katarzyna Bogunia-Kubik, Marta Dratwa, Anna Wojakowska, Grzegorz Mazur, Helena Martynowicz
Summary: This study investigated the relationship between SNP of the TERT gene and the severity of sleep bruxism, and identified the independent risk factors for sleep bruxism. The results showed that one SNP of TERT was associated with the episode index of phasic bruxism, and the lack of this SNP, male sex, and arterial hypertension were independent risk factors for phasic bruxism.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jie Xu, Fang-Ping Xu, Zhi-Hua Liu, Qian Cui, Ke-Ping Zhang, Zhi Li
Summary: This study investigated the correlations between mutations in the TERT promoter and IDH1/2 mutations or 1p/19q deletion in human gliomas. The results showed a positive correlation between TERT promoter mutations and 1p/19q deletion, as well as a negative correlation between TERT promoter mutations and IDH gene mutations, except in certain cases. This suggests a complex inter-regulatory relationship between these mutations in human gliomas.
Review
Oncology
Liu Yang, Na Li, Meng Wang, Yan-Hua Zhang, Lu-Da Yan, Wen Zhou, Zhi-Qiong Yu, Xiao-Chun Peng, Jun Cai
Summary: Non-small cell lung cancer (NSCLC) accounts for a majority of lung cancer cases and is commonly diagnosed at an advanced stage with low survival rates. Activation of telomerase, particularly through telomerase reverse transcriptase (TERT), is associated with the malignant characteristics and prognosis of NSCLC, offering potential therapeutic applications for the treatment of this disease.
Review
Biochemistry & Molecular Biology
Anastasia I. I. Palamarchuk, Elena I. I. Kovalenko, Maria A. A. Streltsova
Summary: TERT, as a core component of telomerase, is not only responsible for lengthening telomeres, but also involved in multiple signaling pathways with various intracellular localizations and functions. Upregulation of TERT expression and increased telomerase activity in cancer and somatic cells are associated with improved survival and persistence.
Review
Immunology
Xin Yu, Meng-Meng Liu, Cai-Yun Zheng, Yu-Tong Liu, Zhuo Wang, Zhan-You Wang
Summary: Neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and Amyotrophic lateral sclerosis, are chronic conditions that progressively damage the nervous system. Age is a major risk factor for NDs, and telomere shortening is considered a marker of cellular aging. Telomerase reverse transcriptase (TERT) helps maintain telomere length and may play a role in T cell senescence and NDs. This review highlights the research on TERT in NDs and explores its potential links with T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Marta Mellai, Omar Porrini Prandini, Aurora Mustaccia, Valentina Fogazzi, Marta Allesina, Marco Krengli, Renzo Boldorini
Summary: pTERT mutations were significantly associated with histologic grade and prognosis in malignant meningiomas, supporting their use in prognostic classification. The mutation rate was higher in anaplastic meningiomas compared to atypical tumors, indicating their potential as adverse prognostic factors.
Article
Biochemistry & Molecular Biology
Alessandra Galati, Livia Scatolini, Emanuela Micheli, Francesca Bavasso, Alessandro Cicconi, Paolo Maccallini, Lu Chen, Caitlin M. Roake, Stefan Schoeftner, Steven E. Artandi, Maurizio Gatti, Stefano Cacchione, Grazia D. Raffa
Summary: Mutations in genes controlling telomerase can cause telomere biology disorders (TBD). Loss of TGS1 can increase hTR abundance and telomerase activity, leading to telomere elongation. Treatment with sinefungin inhibits TGS1 activity, increases hTR levels, and promotes telomere lengthening.