期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 22, 期 11, 页码 844-847出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3098
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资金
- Intramural NIH HHS [ZIA DK036146-09] Funding Source: Medline
- NIDDK NIH HHS [DK036146-08] Funding Source: Medline
We propose a DNA-hairpin model for the processivity of telomeric-repeat addition. Concomitantly with template-RNA translocation after each repeat synthesis, the complementary DNA repeat, for example, AGGGTT, loops out in a noncanonical base-paired hairpin, thus freeing the RNA template for the next round of repeat synthesis. The DNA hairpin is temporarily stabilized by telomerase and the incoming dGTP but becomes realigned for processive telomere synthesis.
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