Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

Reactivation of telomerase in cancer

(2016) Semih Can Akincilar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

hTERT promotes cell adhesion and migration independent of telomerase activity

(2016) Haiying Liu et al.   Scientific Reports

The HSP90 inhibitor alvespimycin enhances the potency of telomerase inhibition by imetelstat in human osteosarcoma

(2015) Yafang Hu et al.   CANCER BIOLOGY & THERAPY

The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells

(2015) Luis Jaime Castro-Vega et al.   CARCINOGENESIS

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

(2015) M. Garcia-Beccaria et al.   EMBO Molecular Medicine

Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation

(2015) Dong-Sheng Huang et al.   EUROPEAN JOURNAL OF CANCER

Human telomerase: biogenesis, trafficking, recruitment, and activation

(2015) Jens C. Schmidt et al.   GENES & DEVELOPMENT

Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity

(2015) Cheryl M. Koh et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Inactivation ofATRXLeads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells

(2015) Rita Eid et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell death during crisis is mediated by mitotic telomere deprotection

(2015) Makoto T. Hayashi et al.   NATURE

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation

(2015) Yinghui Li et al.   NATURE CELL BIOLOGY

Control of telomerase action at human telomeres

(2015) Dirk Hockemeyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles

(2015) Ji Hoon Lee et al.   NUCLEIC ACIDS RESEARCH

Human Rap1 modulates TRF2 attraction to telomeric DNA

(2015) Eliška Janoušková et al.   NUCLEIC ACIDS RESEARCH

Frequency of TERT Promoter Mutations in Prostate Cancer

(2015) Robert Stoehr et al.   PATHOBIOLOGY

TERTpromoter mutations and telomerase reactivation in urothelial cancer

(2015) Sumit Borah et al.   SCIENCE

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

(2015) R. L. Flynn et al.   SCIENCE

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532

(2015) Christopher Bryan et al.   STRUCTURE

Epidermal growth factor activates telomerase activity by direct binding of Ets-2 to hTERT promoter in lung cancer cells

(2015) Chung-Ping Hsu et al.   TUMOR BIOLOGY

Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations

(2015) Dilek Cevik   WORLD JOURNAL OF GASTROENTEROLOGY

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

(2015) David Clynes et al.   Nature Communications

Control of telomerase action at human telomeres

(2015) Dirk Hockemeyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATRX represses alternative lengthening of telomeres

(2015) Christine E. Napier et al.   Oncotarget

The asymmetry of telomere replication contributes to replicative senescence heterogeneity

(2015) Thibault Bourgeron et al.   Scientific Reports

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

(2015) Adrian S. Tong et al.   Cell Reports

ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells

(2015) Stella Suyong Lee et al.   Cell Reports

Cancer-associated TERT promoter mutations abrogate telomerase silencing

(2015) Kunitoshi Chiba et al.   eLife

TERT promoter mutations and monoallelic activation of TERT in cancer

(2015) F W Huang et al.   Oncogenesis

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity

(2015) Emilio Cusanelli et al.   Frontiers in Genetics

TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas

(2015) Kun Wang et al.   Oncotarget

TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR

(2015) Kun Wang et al.   Oncotarget

Noncanonical Functions of Telomerase: Implications in Telomerase-Targeted Cancer Therapies

(2014) Yinghui Li et al.   CANCER RESEARCH

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances

(2014) Jérôme D. Robin et al.   GENES & DEVELOPMENT

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

(2014) Michal Zimmermann et al.   GENES & DEVELOPMENT

Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection

(2014) David Frescas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities

(2014) Christian Koelsche et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial

(2014) Gary Middleton et al.   LANCET ONCOLOGY

A phase II trial evaluating the clinical and immunologic response of HLA-A2+ non-small cell lung cancer patients vaccinated with an hTERT cryptic peptide

(2014) Athanasios Kotsakis et al.   LUNG CANCER

TERT promoter mutations contribute to subset prognostication of lower-grade gliomas

(2014) Aden Ka-Yin Chan et al.   MODERN PATHOLOGY

TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1

(2014) D. Frescas et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomerase Inhibitor Imetelstat (GRN163L) Limits the Lifespan of Human Pancreatic Cancer Cells

(2014) Katrina M. Burchett et al.   PLoS One

Three-dimensional Nuclear Telomere Organization in Multiple Myeloma

(2014) Ludger Klewes et al.   Translational Oncology

Assembly of telomeric chromatin to create ALTernative endings

(2014) Roderick J. O'Sullivan et al.   TRENDS IN CELL BIOLOGY

Alternative splicing regulation of telomerase: a new paradigm?

(2014) Mandy S. Wong et al.   TRENDS IN GENETICS

Telomerase promoter mutations in cancer: an emerging molecular biomarker?

(2014) João Vinagre et al.   VIRCHOWS ARCHIV

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

Induction of Telomere Dysfunction Mediated by the Telomerase Substrate Precursor 6-Thio-2′-Deoxyguanosine

(2014) Ilgen Mender et al.   Cancer Discovery

Identification of human TERT elements necessary for telomerase recruitment to telomeres

(2014) Jens C Schmidt et al.   eLife

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

(2013) Christian Koelsche et al.   ACTA NEUROPATHOLOGICA

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

A Multicenter Randomized Phase IIb Efficacy Study of Vx-001, a Peptide-Based Cancer Vaccine as Maintenance Treatment in Advanced Non–Small-Cell Lung Cancer: Treatment Rationale and Protocol Dynamics

(2013) Vassilis Georgoulias et al.   Clinical Lung Cancer

TERT promoter mutations in cancer development

(2013) Barbara Heidenreich et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Highly prevalent TERT promoter mutations in aggressive thyroid cancers

(2013) Xiaoli Liu et al.   ENDOCRINE-RELATED CANCER

Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome

(2013) Yves Allory et al.   EUROPEAN UROLOGY

Inhibition of Telomerase Recruitment and Cancer Cell Death

(2013) Mai Nakashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting homologous recombination and telomerase in Barrett’s adenocarcinoma: impact on telomere maintenance, genomic instability and tumor growth

(2013) R Lu et al.   ONCOGENE

TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism

(2013) P. S. Rachakonda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Frequency of TERT promoter mutations in human cancers

(2013) João Vinagre et al.   Nature Communications

Are Short Telomeres Predictive of Advanced Cancer?

(2013) J. W. Shay   Cancer Discovery

Novel anticancer therapeutics targeting telomerase

(2012) Maria Ruden et al.   CANCER TREATMENT REVIEWS

Telomerase directly regulates NF-κB-dependent transcription

(2012) Arkasubhra Ghosh et al.   NATURE CELL BIOLOGY

Telomerase reverse transcriptase promotes epithelial–mesenchymal transition and stem cell-like traits in cancer cells

(2012) Z Liu et al.   ONCOGENE

Loss of Wild-Type ATRX Expression in Somatic Cell Hybrids Segregates with Activation of Alternative Lengthening of Telomeres

(2012) Kylie Bower et al.   PLoS One

Targeting telomerase-expressing cancer cells

(2011) Michel M. Ouellette et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Is telomerase a viable target in cancer?

(2011) C.M. Buseman et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Architecture of human telomerase RNA

(2011) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

Role of telomeres and telomerase in cancer

(2011) Jerry W. Shay et al.   SEMINARS IN CANCER BIOLOGY

The Telomerase Antagonist, Imetelstat, Efficiently Targets Glioblastoma Tumor-Initiating Cells Leading to Decreased Proliferation and Tumor Growth

(2010) C. O. Marian et al.   CLINICAL CANCER RESEARCH

Cancer vaccination with telomerase peptide GV1001

(2009) Jon Amund Kyte   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

(2009) A. S. Venteicher et al.   SCIENCE

Identification of ATPases Pontin and Reptin as Telomerase Components Essential for Holoenzyme Assembly

(2008) Andrew S. Venteicher et al.   CELL

Prospects and challenges of building a cancer vaccine targeting telomerase

(2007) Robert H. Vonderheide   BIOCHIMIE