The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated  -Cell Death

(2011) S. Arif et al.   DIABETES

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic  -Cell Apoptosis via Regulation of the BH3-Only Protein Bim

(2011) I. Santin et al.   DIABETES

Clusters of Conserved Beta Cell Marker Genes for Assessment of Beta Cell Phenotype

(2011) Geert A. Martens et al.   PLoS One

A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci

(2011) Jonathan P. Bradfield et al.   PLoS Genetics

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance

(2011) Maikel L. Colli et al.   PLoS Pathogens

Islet inflammation and CXCL10 in recent-onset type 1 diabetes

(2010) B. O. Roep et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Infant and Childhood Diet and Type 1 Diabetes Risk: Recent Advances and Prospects

(2010) Jill M. Norris   Current Diabetes Reports

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

(2010) M. Igoillo-Esteve et al.   DIABETOLOGIA

Expression of chemokines, CXC chemokine ligand 10 (CXCL10) and CXCR3 in the inflamed islets of patients with recent-onset autoimmune type 1 diabetes

(2010) Sae Uno et al.   ENDOCRINE JOURNAL

Protection against or triggering of Type 1 diabetes? Different roles for viral infections

(2010) Tobias Boettler et al.   Expert Review of Clinical Immunology

Etiology of Type 1 Diabetes

(2010) John A. Todd   IMMUNITY

p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress

(2010) Esteban N. Gurzov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation

(2010) Fabrice Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptome genetics using second generation sequencing in a Caucasian population

(2010) Stephen B. Montgomery et al.   NATURE

RNA-Seq analysis to capture the transcriptome landscape of a single cell

(2010) Fuchou Tang et al.   Nature Protocols

Genomics, Type 2 Diabetes, and Obesity

(2010) Mark I. McCarthy   NEW ENGLAND JOURNAL OF MEDICINE

Prediction of alternative isoforms from exon expression levels in RNA-Seq experiments

(2010) Hugues Richard et al.   NUCLEIC ACIDS RESEARCH

Integrative Modeling Defines the Nova Splicing-Regulatory Network and Its Combinatorial Controls

(2010) C. Zhang et al.   SCIENCE

Most “Dark Matter” Transcripts Are Associated With Known Genes

(2010) Harm van Bakel et al.   PLOS BIOLOGY

Detailed transcriptome atlas of the pancreatic beta cell

(2009) Burak Kutlu et al.   BMC Medical Genomics

RNA and Disease

(2009) Thomas A. Cooper et al.   CELL

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

(2009) E N Gurzov et al.   CELL DEATH AND DIFFERENTIATION

Decrypting the genome's alternative messages

(2009) Britta Hartmann et al.   CURRENT OPINION IN CELL BIOLOGY

Cytokines Interleukin-1  and Tumor Necrosis Factor-  Regulate Different Transcriptional and Alternative Splicing Networks in Primary  -Cells

(2009) F. Ortis et al.   DIABETES

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

(2009) Daniel A. Cunha et al.   DIABETES

Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-κB) signalling in human islets and in a mouse beta cell line

(2009) S. A. Sarkar et al.   DIABETOLOGIA

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA

(2009) Maikel L. Colli et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Genetics of Type 1A Diabetes

(2009) Patrick Concannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

PPI spider: A tool for the interpretation of proteomics data in the context of protein-protein interaction networks

(2009) Alexey V. Antonov et al.   PROTEOMICS

Use of a systems biology approach to understand pancreatic β-cell death in Type 1 diabetes

(2008) Decio L. Eizirik et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?

(2008) J. C. Florez   DIABETOLOGIA

Expression of Neurexin, Neuroligin, and Their Cytoplasmic Binding Partners in the Pancreatic β-Cells and the Involvement of Neuroligin in Insulin Secretion

(2008) Arthur T. Suckow et al.   ENDOCRINOLOGY

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: Crystal structure of human Bfl-1 in complex with Bim

(2008) Maria Dolores Herman et al.   FEBS LETTERS

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Tissue-specific splicing factor gene expression signatures

(2008) Ana Rita Grosso et al.   NUCLEIC ACIDS RESEARCH

NCBI Reference Sequences: current status, policy and new initiatives

(2008) K. D. Pruitt et al.   NUCLEIC ACIDS RESEARCH

The Transcriptional Landscape of the Yeast Genome Defined by RNA Sequencing

(2008) U. Nagalakshmi et al.   SCIENCE

A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome

(2008) M. Sultan et al.   SCIENCE