α-granule biogenesis: from disease to discovery

Arf6 controls platelet spreading and clot retraction via integrin  IIb 3 trafficking

(2016) Y. Huang et al.   BLOOD

ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination

(2016) Mohammed Ali Akbar et al.   IMMUNITY

Vps33b regulates Vwf-positive vesicular trafficking in megakaryocytes

(2016) Jing Dai et al.   JOURNAL OF PATHOLOGY

CATCHR, HOPS and CORVET tethering complexes share a similar architecture

(2016) Hui-Ting Chou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct roles of the two VPS33 proteins in the endolysosomal system inCaenorhabditis elegans

(2016) Keiko Gengyo-Ando et al.   TRAFFIC

Finding the Golgi: Golgin Coiled-Coil Proteins Show the Way

(2016) Alison K. Gillingham et al.   TRENDS IN CELL BIOLOGY

Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis

(2016) Blerida Banushi et al.   Nature Communications

CATCHR, HOPS and CORVET tethering complexes share a similar architecture

(2016) Hui-Ting Chou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

VPS33B regulates protein sorting into and maturation of  -granule progenitor organelles in mouse megakaryocytes

(2015) D. Bem et al.   BLOOD

Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and HemostasisClinical Perspective

(2015) Binggang Xiang et al.   CIRCULATION

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity

(2015) Rik van der Kant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

(2015) R. W. Baker et al.   SCIENCE

Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

(2015) B. Lo et al.   SCIENCE

Vps33B is required for delivery of endocytosed cargo to lysosomes

(2015) Romain Galmes et al.   TRAFFIC

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes

(2015) Lena Wartosch et al.   TRAFFIC

Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein

(2014) M. Bender et al.   BLOOD

Gray platelet syndrome: proinflammatory megakaryocytes and  -granule loss cause myelofibrosis and confer metastasis resistance in mice

(2014) J. A. Guerrero et al.   BLOOD

Characterization of the platelet granule proteome: Evidence of the presence of MHC1 in alpha-granules

(2014) Anne Zufferey et al.   Journal of Proteomics

Mammalian CORVET Is Required for Fusion and Conversion of Distinct Early Endosome Subpopulations

(2014) Enrico D. Perini et al.   TRAFFIC

Abnormal megakaryocyte development and platelet function in Nbeal2-/- mice

(2013) W. H. A. Kahr et al.   BLOOD

Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets

(2013) F. Pertuy et al.   BLOOD

Lysosome-related organelles: unusual compartments become mainstream

(2013) Michael S Marks et al.   CURRENT OPINION IN CELL BIOLOGY

Congenital Thrombocytopenia

(2013) Riten Kumar et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice

(2013) Carsten Deppermann et al.   JOURNAL OF CLINICAL INVESTIGATION

A Dominant-Negative GFI1B Mutation in the Gray Platelet Syndrome

(2013) Davide Monteferrario et al.   NEW ENGLAND JOURNAL OF MEDICINE

The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes

(2013) H. J. k. Balderhaar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The BEACH Is Hot: A LYST of Emerging Roles for BEACH-Domain Containing Proteins in Human Disease

(2013) Andrew R. Cullinane et al.   TRAFFIC

Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity

(2012) Gabriela Lopez-Herrera et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet  -granule biogenesis

(2012) D. Urban et al.   BLOOD

Associations among genotype, clinical phenotype, and intracellular localization of trafficking proteins in ARC syndrome

(2012) Holly Smith et al.   HUMAN MUTATION

Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex

(2012) Braden T. Lobingier et al.   MOLECULAR BIOLOGY OF THE CELL

Vesicle-associated Membrane Protein 8 (VAMP8) Is a SNARE (SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Selectively Required for Sequential Granule-to-granule Fusion

(2011) Natasha Behrendorff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome

(2011) Walter HA Kahr et al.   NATURE GENETICS

Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome

(2011) Cornelis A Albers et al.   NATURE GENETICS

NBEAL2 is mutated in gray platelet syndrome and is required for biogenesis of platelet α-granules

(2011) Meral Gunay-Aygun et al.   NATURE GENETICS

Gray platelet syndrome: natural history of a large patient cohort and locus assignment to chromosome 3p

(2010) M. Gunay-Aygun et al.   BLOOD

Agranular Platelets as a Cardinal Feature of ARC Syndrome

(2010) Seong Min Kim et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

The α-granule proteome: novel proteins in normal and ghost granules in gray platelet syndrome

(2010) D. M. MAYNARD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization

(2010) Andrew R Cullinane et al.   NATURE GENETICS

The SM protein Vps33 and the t-SNARE Habc domain promote fusion pore opening

(2010) Michel Pieren et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Platelet α-granules: Basic biology and clinical correlates

(2009) Price Blair et al.   BLOOD REVIEWS

Vps-C complexes: gatekeepers of endolysosomal traffic

(2009) Daniel P Nickerson et al.   CURRENT OPINION IN CELL BIOLOGY

Selective sorting of alpha-granule proteins

(2009) J. E. ITALIANO JR. et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

(2009) Takeshi Ohya et al.   NATURE

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Disorders of Lysosome-Related Organelle Biogenesis: Clinical and Molecular Genetics

(2008) Marjan Huizing et al.   Annual Review of Genomics and Human Genetics

Molecular investigations to improve diagnostic accuracy in patients with ARC syndrome

(2008) Andrew R. Cullinane et al.   HUMAN MUTATION

SPE-39 Family Proteins Interact with the HOPS Complex and Function in Lysosomal Delivery

(2008) Guang-dan Zhu et al.   MOLECULAR BIOLOGY OF THE CELL