Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

The Role Of Chronic Norovirus Infection In The Enteropathy Associated With Common Variable Immunodeficiency

(2015) Jeremy M Woodward et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like disorder caused by loss-of-function mutations in LRBA

(2015) Louis-Marie Charbonnier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biomarkers of CD4+ T-cell activation as risk factors for tuberculosis-associated immune reconstitution inflammatory syndrome

(2014) Lisa A. Chakrabarti et al.   AIDS

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

(2014) Desirée Schubert et al.   NATURE MEDICINE

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

(2014) H. S. Kuehn et al.   SCIENCE

Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma

(2013) Jedd D. Wolchok et al.   Annals of the New York Academy of Sciences

Long-term safety of abatacept in patients with rheumatoid arthritis

(2013) Fabiola Atzeni et al.   AUTOIMMUNITY REVIEWS

Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity

(2012) Gabriela Lopez-Herrera et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Belatacept in kidney transplantation

(2012) David Wojciechowski et al.   Current Opinion in Organ Transplantation

LRBA gene deletion in a patient presenting with autoimmunity without hypogammaglobulinemia

(2012) Siobhan O. Burns et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

LPS-responsive beige-like anchor (LRBA) gene mutation in a family with inflammatory bowel disease and combined immunodeficiency

(2012) Abdullah Alangari et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation

(2012) Omar S. Qureshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of Combination Chemotherapy for Treatment of Granulomatous and Lymphocytic Interstitial Lung Disease (GLILD) in Patients with Common Variable Immunodeficiency (CVID)

(2012) Nicole M. Chase et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Long-term safety, efficacy and inhibition of radiographic progression with abatacept treatment in patients with rheumatoid arthritis and an inadequate response to methotrexate: 3-year results from the AIM trial

(2011) J. M. Kremer et al.   ANNALS OF THE RHEUMATIC DISEASES

Morbidity and mortality in common variable immune deficiency over 4 decades

(2011) E. S. Resnick et al.   BLOOD

Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation

(2011) Kajsa Wing et al.   TRENDS IN IMMUNOLOGY

Update in understanding common variable immunodeficiency disorders (CVIDs) and the management of patients with these conditions

(2009) Helen Chapel et al.   BRITISH JOURNAL OF HAEMATOLOGY

Safety and Efficacy of the Selective Costimulation Modulator Abatacept in Patients with Rheumatoid Arthritis Receiving Background Methotrexate: A 5-year Extended Phase IIB Study

(2009) R. WESTHOVENS et al.   JOURNAL OF RHEUMATOLOGY

Common variable immunodeficiency disorders: division into distinct clinical phenotypes

(2008) H. Chapel et al.   BLOOD