Insulin resistance and sarcopenia: mechanistic links between common co-morbidities

Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle-derived nitric oxide

(2015) Ying Wang et al.   AGING CELL

AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

(2015) Adam L. Bujak et al.   Cell Metabolism

Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity

(2015) Vanessa Pellegrinelli et al.   DIABETES

Obesity Appears to Be Associated With Altered Muscle Protein Synthetic and Breakdown Responses to Increased Nutrient Delivery in Older Men, but Not Reduced Muscle Mass or Contractile Function

(2015) Andrew J. Murton et al.   DIABETES

Restoring normoglycaemia by use of a very low calorie diet in long- and short-duration Type 2 diabetes

(2015) S. Steven et al.   DIABETIC MEDICINE

Role of insulin in the regulation of human skeletal muscle protein synthesis and breakdown: a systematic review and meta-analysis

(2015) Haitham Abdulla et al.   DIABETOLOGIA

FOXO1 Mediates Vitamin D Deficiency-Induced Insulin Resistance in Skeletal Muscle

(2015) Songcang Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice

(2015) Claus Brandt et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Combination Antisense Treatment for Destructive Exon Skipping of Myostatin and Open Reading Frame Rescue of Dystrophin in Neonatal mdx Mice

(2015) Ngoc B Lu-Nguyen et al.   MOLECULAR THERAPY

Expanding roles for AMPK in skeletal muscle plasticity

(2015) Rémi Mounier et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation

(2014) Nicolas Tardif et al.   AGING CELL

A high whey protein–, leucine-, and vitamin D–enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial

(2014) Amely M Verreijen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Local overexpression of the myostatin propeptide increases glucose transporter expression and enhances skeletal muscle glucose disposal

(2014) M. E. Cleasby et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice

(2014) Ying Liu et al.   DIABETES

Lipid-Induced Insulin Resistance Is Associated With an Impaired Skeletal Muscle Protein Synthetic Response to Amino Acid Ingestion in Healthy Young Men

(2014) Francis B. Stephens et al.   DIABETES

Sarcopenia, sarcopenic obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III

(2014) J A Batsis et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Skeletal muscle capillary density and microvascular function are compromised with aging and type 2 diabetes

(2014) Bart B. L. Groen et al.   JOURNAL OF APPLIED PHYSIOLOGY

The Effects of Vitamin D on Skeletal Muscle Strength, Muscle Mass, and Muscle Power: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2014) Charlotte Beaudart et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle

(2014) Manon M Roustit et al.   JOURNAL OF ENDOCRINOLOGY

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance

(2014) Nicola A. Talbot et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

(2014) Christopher S Fry et al.   NATURE MEDICINE

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

(2014) Jennifer D Bernet et al.   NATURE MEDICINE

Sarcopenic obesity and dynapenic obesity: 5-year associations with falls risk in middle-aged and older adults

(2014) David Scott et al.   Obesity

Aerobic Exercise Attenuates the Loss of Skeletal Muscle during Energy Restriction in Adults with Visceral Adiposity

(2014) Eiichi Yoshimura et al.   Obesity Facts

Lkb1 Is Indispensable for Skeletal Muscle Development, Regeneration, and Satellite Cell Homeostasis

(2014) Tizhong Shan et al.   STEM CELLS

Association of physical activity with sarcopenia and sarcopenic obesity in community-dwelling older adults: the Fourth Korea National Health and Nutrition Examination Survey

(2013) M. Ryu et al.   AGE AND AGEING

Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study

(2013) F. Landi et al.   AGE AND AGEING

Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength

(2013) Karel G. M. Beenakker et al.   AGING CELL

Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway

(2013) M. Sandri et al.   BIOGERONTOLOGY

Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity

(2013) Mats I. Nilsson et al.   FASEB JOURNAL

Mechanisms regulating skeletal muscle growth and atrophy

(2013) Stefano Schiaffino et al.   FEBS Journal

Selective inhibition of ATPase activity during contraction alters the activation of p38 MAP kinase isoforms in skeletal muscle

(2013) Jeffrey J. Brault et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Slow-Twitch Fiber Proportion in Skeletal Muscle Correlates With Insulin Responsiveness

(2013) Charles A. Stuart et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Randomized Study on the Effect of Vitamin D3Supplementation on Skeletal Muscle Morphology and Vitamin D Receptor Concentration in Older Women

(2013) Lisa Ceglia et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

(2013) Nigel Turner et al.   JOURNAL OF ENDOCRINOLOGY

Pro-Inflammatory macrophages increase in skeletal muscle of high fat-Fed mice and correlate with metabolic risk markers in humans

(2013) Lisbeth N. Fink et al.   Obesity

Evidence against a Beneficial Effect of Irisin in Humans

(2013) Silja Raschke et al.   PLoS One

Sarcopenic obesity

(2013) Matthew F. Bouchonville et al.   Current Opinion in Endocrinology Diabetes and Obesity

The effect of vitamin D on insulin resistance in patients with type 2 diabetes

(2013) Afsaneh Talaei et al.   Diabetology & Metabolic Syndrome

Sarcopenia in the aging high-fat fed rat: a pilot study for modeling sarcopenic obesity in rodents

(2012) L. Cornelius Bollheimer et al.   BIOGERONTOLOGY

Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones?

(2012) Manthos G. Giannoulis et al.   ENDOCRINE REVIEWS

Overexpression of the Adiponectin Receptor AdipoR1 in Rat Skeletal Muscle Amplifies Local Insulin Sensitivity

(2012) S. A. Patel et al.   ENDOCRINOLOGY

Time-course changes of muscle protein synthesis associated with obesity-induced lipotoxicity

(2012) Aurélie Masgrau et al.   JOURNAL OF PHYSIOLOGY-LONDON

Is irisin a human exercise gene?

(2012) James A. Timmons et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Low Macrophage Accumulation in Skeletal Muscle of Obese Type 2 Diabetics and Elderly Subjects

(2012) Charmaine S. Tam et al.   Obesity

Beyond the body mass index: tracking body composition in the pathogenesis of obesity and the metabolic syndrome

(2012) M. J. Müller et al.   Obesity Reviews

Body composition changes over 9 years in healthy elderly subjects and impact of physical activity

(2011) Laurence Genton et al.   CLINICAL NUTRITION

Oleate-enriched diet improves insulin sensitivity and restores muscle protein synthesis in old rats

(2011) Nicolas Tardif et al.   CLINICAL NUTRITION

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

(2011) C. Zhang et al.   DIABETOLOGIA

Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet

(2011) P. M. Jamieson et al.   DIABETOLOGIA

Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway

(2011) C. Zhang et al.   DIABETOLOGIA

Ectopic Lipid Accumulation and Reduced Glucose Tolerance in Elderly Adults Are Accompanied by Altered Skeletal Muscle Mitochondrial Activity

(2011) Darcy L. Johannsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sarcopenia With Limited Mobility: An International Consensus

(2011) John E. Morley et al.   Journal of the American Medical Directors Association

Serum Concentrations of Myostatin and Myostatin-Interacting Proteins Do Not Differ Between Young and Sarcopenic Elderly Men

(2011) A. Ratkevicius et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Dynapenia and Aging: An Update

(2011) Todd M. Manini et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial

(2011) James T. Dalton et al.   Journal of Cachexia Sarcopenia and Muscle

Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People

(2010) A. J. Cruz-Jentoft et al.   AGE AND AGEING

Impaired overload-induced hypertrophy is associated with diminished mTOR signaling in insulin-resistant skeletal muscle of the obese Zucker rat

(2010) Anjaiah Katta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hypophosphatemia is responsible for skeletal muscle weakness of vitamin D deficiency

(2010) Laurie Schubert et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Pharmacological Vasodilation Improves Insulin-Stimulated Muscle Protein Anabolism but Not Glucose Utilization in Older Adults

(2010) K. L. Timmerman et al.   DIABETES

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Prevalence and Determinant Factors of Sarcopenia in Patients With Type 2 Diabetes: The Korean Sarcopenic Obesity Study (KSOS)

(2010) T. N. Kim et al.   DIABETES CARE

Yearlong physical activity and sarcopenia in older adults: the Nakanojo Study

(2010) Hyuntae Park et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model

(2010) Balindiwe Sishi et al.   EXPERIMENTAL PHYSIOLOGY

A Sequence Polymorphism in MSTN Predicts Sprinting Ability and Racing Stamina in Thoroughbred Horses

(2010) Emmeline W. Hill et al.   PLoS One

Prospective associations between ambulatory activity, body composition and muscle function in older adults

(2010) D. Scott et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia

(2009) Emilie A Wilkes et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Longitudinal study of muscle strength, quality, and adipose tissue infiltration

(2009) et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins

(2009) Kari E. Wong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Excessive Loss of Skeletal Muscle Mass in Older Adults With Type 2 Diabetes

(2009) S. W. Park et al.   DIABETES CARE

Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism

(2009) S. Fujita et al.   DIABETOLOGIA

A Novel Synthetic Androgen Receptor Ligand, S42, Works as a Selective Androgen Receptor Modulator and Possesses Metabolic Effects with Little Impact on the Prostate

(2009) Liu Min et al.   ENDOCRINOLOGY

The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

(2009) I Akpan et al.   INTERNATIONAL JOURNAL OF OBESITY

Changes in Basal and Insulin and Amino Acid Response of Whole Body and Skeletal Muscle Proteins in Obese Men

(2009) Christelle Guillet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Skeletal Muscle and Mortality Results From the InCHIANTI Study

(2009) M. Cesari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity

(2009) Tingqing Guo et al.   PLoS One

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance

(2008) Alexander V. Chibalin et al.   CELL

LKB1 and AMPK and the regulation of skeletal muscle metabolism

(2008) Ho-Jin Koh et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Lean Phenotype and Resistance to Diet-Induced Obesity in Vitamin D Receptor Knockout Mice Correlates with Induction of Uncoupling Protein-1 in White Adipose Tissue

(2008) Carmen J. Narvaez et al.   ENDOCRINOLOGY

The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance

(2008) A. M. Traish et al.   JOURNAL OF ANDROLOGY

The developmental origins of sarcopenia

(2008) A. A. Sayer et al.   Journal of Nutrition Health & Aging

Diet-induced obesity alters protein synthesis: tissue-specific effects in fasted versus fed mice

(2008) Stephanie R. Anderson et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Human Sarcopenia Reveals an Increase in SOCS-3 and Myostatin and a Reduced Efficiency of Akt Phosphorylation

(2008) Bertrand Léger et al.   REJUVENATION RESEARCH

Local activation of the IκK-NF-κB pathway in muscle does not cause insulin resistance

(2007) Emma Polkinghorne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM